Condition
Treatment Resistant Major Depressive Disorder
ClinicalTrials.gov condition label
How to interpret these research links
Connected source recordsThis is the original ClinicalTrials.gov condition label, found in 7 distinct published trials. It is kept separate from a MONDO disease identifier until a specific normalization is supported. Related interventions are co-recorded in studies; they are not medical recommendations.
Data basis: current published ClinicalTrials.gov records and, where present, RxNorm, MONDO and FDA-label identifiers. See the evidence interpretation and counting methodology.
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Clinical trials
7 shownRepeated Intranasal Esketamine Plus Almond Therapy in Participants With Treatment Resistant Depressive Disorder - 3 Month Extension StudyNCT05438758 · 2023-01-15
WITHDRAWNRepeated Intranasal Esketamine Plus Almond Therapy in Patients With Treatment Resistant DepressionNCT05323019 · 2022-10-13
TERMINATEDRemotely Programmed Deep Brain Stimulation of the Bilateral Habenula for Treatment- Resistant Major Depression: An Open Label Pilot TrialNCT03254017 · 2017-07-24
TERMINATEDComparative Effectiveness Research Trial for Antidepressant Incomplete and Non-responders With TRDNCT02977299 · 2017-07-13
COMPLETEDA Study to Assess the Efficacy and Safety of AXS-05 in Subjects With Treatment Resistant Major Depressive DisorderNCT02741791 · 2016-03-01
COMPLETEDDBS of the Lateral Habenula in Treatment-Resistant DepressionNCT01798407 · 2013-02-01
ACTIVE_NOT_RECRUITINGThis is a Study to Determine the Antidepressant Effects of AZD6765NCT00986479 · 2009-12-01
COMPLETEDCommon interventions
Intranasal Ketamine (esketamine)DRUG2Treatment as UsualBEHAVIORAL2Activa Tremor Control Sys (DBS Implant)DEVICE1Almond TherapyBEHAVIORAL1AripiprazoleDRUG1AXS-05DRUG1AZD6765DRUG1Bilateral surgical implantation of DBS system to HabelunaPROCEDURE1BupropionDRUG1Follow-up PeriodOTHER1Placebo to AZD6765DRUG1PsychotherapyBEHAVIORAL1Randomized, staggered withdrawal phaseOTHER1Repetitive transcranial magnetic stimulation (rTMS)DEVICE1Venlafaxine XRDRUG1
Leading sponsors
Trial status mix
COMPLETED3
TERMINATED2
ACTIVE_NOT_RECRUITING1
WITHDRAWN1
Phase mix
PHASE23
NA2
PHASE31
PHASE41
Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.