Condition

Osteoarthritis, Knee

ClinicalTrials.gov condition label

Clinical trials50
Recruiting9
Common interventions25
Lead sponsors shown15

Clinical trials

50 shown
AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce PainNCT07509307 · 2026-04-20
RECRUITING
Study to Evaluate the Performance of Navigated TKA With OrthoPilot® pheno4u TKA Level 1NCT06955481 · 2025-10-07
RECRUITING
Subcutaneous Tirzepatide Once-weekly in Patients With Obesity and Knee Osteoarthritis (STOP KNEE-OA)NCT06191848 · 2024-11-19
RECRUITING
Knee Osteoarthritis Treatment With Zilretta vs. Kenalog in the Context of Type II DiabetesNCT06478186 · 2024-08-16
RECRUITING
Comparative Study of Navigation-assisted OrthoPilot® Elite and Robotic-assisted MAKO® Total Knee ArthroplastyNCT05980442 · 2024-07-03
RECRUITING
The Osteoarthritis Prevention StudyNCT05946044 · 2024-03-21
RECRUITING
Partial Synovectomy in Articular Side of Quadriceps Tendon Verified to Reduce Crepitus in Retrospective StudyNCT06129214 · 2023-10-16
RECRUITING
The ATtune Knee Outcome StudyNCT04247672 · 2020-02-03
RECRUITING
Physica System Total Knee Replacement Registry StudyNCT03048201 · 2017-03-24
RECRUITING
Pre-emptive Insulin to Prevent High Glucose After a Knee Steroid Injection in Adults With Type 2 DiabetesNCT07757464 · 2026-08-10
ACTIVE_NOT_RECRUITING
The Clinical Impact of Diet on Medical Conditions Treated Within Bundled Payment Models: a Pilot StudyNCT05735873 · 2024-11-01
WITHDRAWN
Barriers and Faciliators for Physical Activity in People With RMDsNCT06514443 · 2024-08-01
UNKNOWN
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or OverweightNCT05929066 · 2023-07-10
COMPLETED
A Hip Flexion Feedback System for Exercise Monitoring in Individuals With Osteoarthritis and ObesityNCT05997862 · 2023-07-01
UNKNOWN
Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)NCT05787821 · 2023-06-28
ACTIVE_NOT_RECRUITING
Total Joint Arthroplasty (TJA) Weight Loss StudyNCT05156762 · 2022-10-03
TERMINATED
Role of Topical Vancomycin in Reducing Infections in Hip and Knee ArthroplastyNCT05972603 · 2022-07-01
UNKNOWN
OA Optimization Program Pilot TrialNCT05389371 · 2022-06-28
UNKNOWN
OA Clinic-Community CARE ModelNCT05349500 · 2022-06-07
COMPLETED
Algarve Active Ageing - Cardiac and Osteoarthritis Rehabilitation (A3-COR)NCT05999110 · 2022-06-01
UNKNOWN
Impact of a POPOP on Preoperative Health, Eligibility, and Clinical & Patient-Reported Outcomes in TJANCT04910048 · 2022-01-17
COMPLETED
Continuous Glycemia Monitoring in Perioperative Period in Patients Undergoing Total Knee or Hip ArthroplastyNCT04444570 · 2021-12-01
UNKNOWN
A Telehealth Study of a Wearable Electroceutical & Sports Sleeve for Knee Osteoarthritis Pain Relief & Improved FunctionNCT04938271 · 2021-11-22
UNKNOWN
Personalized Exercise Therapy and Self-management Support for Patients With MultimorbidityNCT04645732 · 2021-11-01
COMPLETED
The POMELO (Prevention Of MusclE Loss in Osteoarthritis) TrialNCT05026385 · 2021-09-20
COMPLETED
Evaluation of Medium Cross-linked Polyethylene With and Without Vitamin E for Total Knee ArthroplastyNCT04618016 · 2021-03-08
ACTIVE_NOT_RECRUITING
Evaluation of The Safety And Performance of The Freedom Total Knee® System With The PEEK-OPTIMA Femoral ComponentNCT03224689 · 2021-01-01
UNKNOWN
Assessment of 99mTc-NTP 15-5 Uptake on Cartilage, a New Proteoglycan TracerNCT04481230 · 2020-11-12
COMPLETED
Characteristics of Marrow Fatty Cells in the Ageing of Bone and Joints, Osteoarthritis and OsteoporosisNCT03678831 · 2020-06-30
COMPLETED
Increased Blood Glucose Levels After Steroid InjectionNCT06228911 · 2020-01-15
COMPLETED
Chronic Pain, Couples, & Physical ActivityNCT04077164 · 2019-04-09
TERMINATED
Effect Of The Use Of Navigation In The Alignment Obtained When Performing A Total Knee Arthroplasty In Obese PatientsNCT03865524 · 2019-02-07
COMPLETED
A Comparison of Two Surgical Techniques Using the Unity Knee™ Total Knee SystemNCT03511144 · 2018-07-01
WITHDRAWN
Study of Hip and Knee Arthroplasty in South AfricaNCT03540667 · 2018-05-07
COMPLETED
Effects of Diet Control and Resistance Exercise Training on Obesity Adults With Knee OsteoarthritisNCT03973463 · 2018-05-03
UNKNOWN
Early Biomarkers for ARthritic PAIN to Guide Improved Treatments for ArthritisNCT03533569 · 2018-04-02
UNKNOWN
Effects of a Clinical Dietary Intervention During Inpatient TreatmentNCT03785197 · 2018-02-01
UNKNOWN
Transplantation of Autologous Bone Marrow Derived Stem Cells in Patients With Rheumatoid ArthritisNCT03067870 · 2016-11-01
UNKNOWN
Changes in Skin Autoflouresence Following Weight Loss and Maintenance Using Liraglutide in Knee OsteoarthritisNCT02910570 · 2016-11-01
COMPLETED
Weight Loss and Physical Activity in Overweight/Obese Individuals With Knee OsteoarthritisNCT02910544 · 2016-11-01
COMPLETED
Comparison of Treatments Following Total Knee ReplacementNCT02237911 · 2014-12-01
COMPLETED
Staying Active With Arthritis: RCT of Physical Activity for Older Adults With Osteoarthritis and HypertensionNCT01280903 · 2012-01-01
COMPLETED
Weight Loss Intervention Before Total Knee ReplacementNCT01469403 · 2011-08-01
COMPLETED
Vanguard Rocc Post Market SurveillanceNCT03664791 · 2009-10-23
UNKNOWN
Long-term Intervention With Weight Loss in Patients With Concomitant Obesity and Knee Osteoarthritis. The LIGHT StudyNCT00938808 · 2009-06-01
COMPLETED
Influence of Weight Loss or Exercise on Cartilage in Obese Knee Osteoarthritis PatientsNCT00655941 · 2008-04-01
COMPLETED
Improving Motivation for Physical Activity in Arthritis Clinical TrialNCT00248105 · 2005-09-01
COMPLETED
Gamma Vacuum Foil (GVF) Versus Cross-linked Polyethylene in Total Knee Arthroplasty StudyNCT00289133 · 2005-02-01
COMPLETED
Balanced Knee System Clinical Protocol for IRB ApprovalNCT02362867 · 2003-01-01
COMPLETED
Prevention of Arthritis-Related Work DisabilityNCT00000416 · 1997-09-01
COMPLETED

Common interventions

PlaceboDRUG2Total Knee ArthroplastyDEVICE20,35% povidone-iodine solution lavagePROCEDURE11.0 g Vancomycin powder into the woundPROCEDURE18 weeks weight loss program, Cambridge.BEHAVIORAL199mTc-NTP 15-5 at a diagnostic activity of 10 MBq/kgDRUG199mTc-NTP 15-5 at a diagnostic activity of 15 MBq/kgDRUG199mTc-NTP 15-5 at a diagnostic activity of 5 MBq/kgDRUG1Alberta Healthy Living ProgramBEHAVIORAL1Alberta Obesity Centre ProgramBEHAVIORAL1Attention-ControlBEHAVIORAL1Balanced Knee SystemDEVICE1Bariatric surgeryPROCEDURE1Clinic-based outpatient exercise groupOTHER1Community-based exercise groupOTHER1Continuous glycemia measuring device (Dexcom) implantation into the subcutaneous tissueDEVICE1day formula dietDIETARY_SUPPLEMENT1Diet and ExerciseBEHAVIORAL1Dietary instructionBEHAVIORAL1Elastic knee joint movementBEHAVIORAL1ExerciseOTHER1HEAL-122 microcurrent electroceutical with e-textile sports knee sleeveDEVICE1HFFSDEVICE1Insulin Isophane Human, NPH, Pre-emptive AlgorithmDRUG1Intensive dietary interventionDIETARY_SUPPLEMENT1

Trial status mix

COMPLETED21
UNKNOWN13
RECRUITING9
ACTIVE_NOT_RECRUITING3
TERMINATED2
WITHDRAWN2

Phase mix

NA26
PHASE14
PHASE23
PHASE43
PHASE32
EARLY_PHASE11

Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.