Condition

Alpha-1 Antitrypsin Deficiency

ClinicalTrials.gov condition label

How to interpret these research links

Connected source records

This is the original ClinicalTrials.gov condition label, found in 9 distinct published trials. It is kept separate from a MONDO disease identifier until a specific normalization is supported. Related interventions are co-recorded in studies; they are not medical recommendations.

Data basis: current published ClinicalTrials.gov records and, where present, RxNorm, MONDO and FDA-label identifiers. See the evidence interpretation and counting methodology.

Clinical trials9

Recruiting0

Common interventions11

Lead sponsors shown8

Clinical trials

9 shown

Long-Term Follow-up Study of ADVM-043NCT03804021 · 2018-12-27

COMPLETED

Targeting Pulmonary Perfusion in Alpha-1 Antitrypsin DeficiencyNCT03008915 · 2017-01-01

COMPLETED

Environment Effect on Six-Minute Walk Test PerformanceNCT02502201 · 2015-10-01

TERMINATED

Microbioma in Sputa From COPD With Alpha-1 Antitrypsin DeficiencyNCT02547532 · 2015-09-01

COMPLETED

Alpha-1 Carrier Genomics StudyNCT02810327 · 2015-02-01

COMPLETED

Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant SuitabilityNCT01615484 · 2013-09-01

COMPLETED

Phase 2 Study of Ex-vivo Perfusion and Ventilation of Lungs to Assess Transplant SuitabilityNCT01241942 · 2010-12-01

TERMINATED

Prevalence of Alpha-1 Antitrypsin Deficiency in Chronic Obstructive Pulmonary Disease (COPD)NCT01419158 · 2008-01-01

COMPLETED

Alpha1-antitrypsin Deficiency RegistryNCT00005292 · 1988-09-01

COMPLETED

Common interventions

Steen Solution™DEVICE2 AspirinDRUG1 collection of sputumOTHER1 Conventional Lung TransplantOTHER1 Genetic SequencingGENETIC1 No InterventionGENETIC1 PlaceboDRUG1 six-minute walk study indoorsOTHER1 six-minute walk study outdoorsOTHER1 Transplantation of lungs obtained from Non-Heart-Beating Donors (NHBDs) after ex-vivo perfusion w/ STEEN Solution™PROCEDURE1 Withdrawal from alpha1 antitrypsin replacement therapyOTHER1

Mapped drugs appearing in these trials

Shared trial participation only; not evidence of efficacy or approval.

aspirin1 placebo1

Leading sponsors

University of North Carolina, Chapel Hill 2 Adverum Biotechnologies, Inc. 1 Alpha-1 Foundation 1 Columbia University 1 Fondazione Salvatore Maugeri 1 Medical University of South Carolina 1 National Heart, Lung, and Blood Institute (NHLBI) 1 University of Florida 1

Trial status mix

COMPLETED7

TERMINATED2

Phase mix

NA3

PHASE21

Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.