Condition
Diastolic Dysfunction
ClinicalTrials.gov condition label
How to interpret these research links
Connected source recordsThis is the original ClinicalTrials.gov condition label, found in 50 distinct published trials. It is kept separate from a MONDO disease identifier until a specific normalization is supported. Related interventions are co-recorded in studies; they are not medical recommendations.
Data basis: current published ClinicalTrials.gov records and, where present, RxNorm, MONDO and FDA-label identifiers. See the evidence interpretation and counting methodology.
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Clinical trials
50 shownHomocysteine and Early Diastolic Dysfunction in Newly Diagnosed HypertensionNCT07480265 · 2025-06-02
RECRUITINGDiastolic Dysfunction and Inflammatory Biomarkers in Lupus NephritisNCT07837544 · 2026-09-20
NOT_YET_RECRUITINGChanges in Intramyocardial Fat Assessed by Cardiac CT Before and After Bariatric Surgery and Their Relationship With Cardiac Diastolic FunctionNCT07565610 · 2026-05-01
NOT_YET_RECRUITINGTimely Recovery After Subclinical Heart FailureNCT06341101 · 2024-03-26
UNKNOWNAssessment of Diastolic Function During the Transitional Period and Infancy Using Serial EchocardiographyNCT06200519 · 2024-02-12
ACTIVE_NOT_RECRUITINGPolyamine Treatment in Elderly Patients With Coronary Artery DiseaseNCT06186102 · 2024-01-01
COMPLETEDTumor Necrosis Factor-alpha Levels and Cardiac Functions in Type 1 Diabetes MellitusNCT06129448 · 2023-12-01
COMPLETEDDiastology-Guided Management of Decompensated Heart FailureNCT06131008 · 2023-11-06
UNKNOWNThe Effect of Addition of Metformin In Obese Non- Diabetic Patients With Heart Failure With Preserved Ejection FractionNCT05847244 · 2023-10-01
UNKNOWNAtrial Fibrillation: Chronic Beta-blocker Use Versus As-needed Rate Control Guided by Implantable Cardiac MonitorNCT05745337 · 2023-02-06
UNKNOWNPrevention of Age-associated Cardiac and Vascular Dysfunction Using Avmacol ESNCT05408559 · 2022-07-01
WITHDRAWNSex Related Differences in Cardiac FunctionNCT05796050 · 2022-02-02
UNKNOWNIntermittent Hypoxic-hyperoxic Training in Patients With Cardiovascular Pathology After COVID-19 Infection.NCT05379608 · 2021-12-10
COMPLETEDDiastolic dYsfunctioN AssessMent in critICally Ill PatientsNCT04584203 · 2021-06-01
UNKNOWNDiastolic Dysfunction in Morbidly Obese Patients Undergo Bariatric SurgeryNCT04128735 · 2019-10-30
COMPLETEDPersonalized Pacing: A New Paradigm for Patients With Diastolic Dysfunction or Heart Failure With Preserved Ejection FractionNCT04721314 · 2019-07-17
COMPLETEDCiprofibrate and Pre-diabetesNCT03662984 · 2018-11-01
COMPLETEDThe Transition From Hypertension to Hypertensive Heart Disease and Heart Failure, the PREFERS Hypertension StudyNCT04190420 · 2018-10-01
ACTIVE_NOT_RECRUITINGHeart Failure and Hemodynamic Stability During Anesthesia InductionNCT03576261 · 2018-08-01
COMPLETEDAssessment of Diastolic Function in High Risk Patients Undergoing Major Vascular SurgeryNCT03534440 · 2018-07-01
COMPLETEDEffect of Dialysis Techniques on Blood Pressure and Cardiac Function During DialysisNCT03249532 · 2018-06-01
COMPLETEDPDD in Type 2 Diabetes w/wo Diastolic DysfunctionNCT03744975 · 2018-05-01
COMPLETEDREWARD: Using the REtina as a Window To Detect Cardiac microvasculAR Dysfunction In Diabetes MellitusNCT04025996 · 2018-02-20
UNKNOWNPrevalence of Hypovolemia and Heart Failure in Non-cardiac SurgeryNCT03349593 · 2017-12-01
COMPLETEDImpact of HMGB1 on Diastolic Dysfunction in Hypertensive PatientsNCT03177408 · 2017-08-15
UNKNOWNFrequency of Asymptomatic Left Ventricular Diastolic Dysfunction in Diabetes Mellitus Type 2NCT03196687 · 2017-07-01
UNKNOWNCharacterizing HIV-related Diastolic DysfunctionNCT02860156 · 2016-11-15
COMPLETEDEffects of Empagliflozin on Left Ventricular Diastolic Function Compared to Usual Care in Type 2 DiabeticsNCT02932436 · 2016-10-10
COMPLETEDMechanisms of Diastolic Dysfunction Among Persons With HIV Compared With Non-HIV Control SubjectsNCT02874703 · 2016-08-01
COMPLETEDPrognostic Impact of Cardiac Diastolic Function and Coronary Microvascular FunctionNCT05058833 · 2016-04-08
COMPLETEDEffect of Liraglutide on Diastolic Dysfunction on Cardiac MRI in Type 2 Diabetes PatientsNCT02655770 · 2016-02-01
COMPLETEDAerobic Versus Combined Exercise and Diastolic DysfunctionNCT04916184 · 2016-01-01
COMPLETEDGhrelin and Diastolic Heart FunctionNCT05988346 · 2016-01-01
COMPLETEDCORolla® TAA for Heart Failure With Preserved Ejection Fraction (HFpEF) and Diastolic Dysfunction (DD)NCT02499601 · 2015-09-01
UNKNOWNEffect of Liraglutide on Cardiovascular Endpoints in Diabetes Mellitus Type 2 Patients of South Asian DescentNCT02660047 · 2015-08-01
COMPLETEDScreening of Diastolic Dysfunction With Impedance Cardiography in Hypertensive PatientsNCT03209141 · 2015-01-02
COMPLETEDDiastolic Dysfunction and Pauci-inflammatory Acute Exacerbations of COPDNCT03110614 · 2013-11-25
COMPLETEDEffect of Liraglutide on Cardiovascular Endpoints in Diabetes Mellitus Type 2 PatientsNCT01761318 · 2013-11-01
COMPLETEDEffect of Dietary Sodium Restriction in the Management of Patients With Heart Failure and Diastolic DysfunctionNCT01896908 · 2013-03-01
COMPLETEDRelation of Visceral Fat and Associated Cytokines With Early Cardiovascular Complications in Type 1 Diabetes.NCT02689570 · 2011-06-01
UNKNOWNThe Effect of Heart Rate on Cardiac Index in Patients With Left Ventricular HypertrophyNCT01241838 · 2011-02-01
TERMINATEDEffects of Levosimendan in Patients Eligible for Aortic Valve Replacement With Left Ventricular HypertrophyNCT01188369 · 2010-09-01
TERMINATEDEffects of Pycnogenol on Cardiac Fibrosis and Diastolic Dysfunction in Aged Hypertensive SubjectsNCT00952627 · 2009-07-01
TERMINATEDDisease Prevention in Clinical Practice Base on Patient Specific PhysiologyNCT03308773 · 2009-01-05
ENROLLING_BY_INVITATIONPre-clinical Cardiac Dysfunction Among Asymptomatic Hypertensive PatientsNCT00689819 · 2008-10-01
COMPLETEDWeight Loss in Pre-Hypertensive Patients With Diastolic DysfunctionNCT00911209 · 2008-07-01
TERMINATEDThe Effects of Systolic Blood Pressure Lowering on Diastolic Function Using Valsartan + Amlodipine in Patients With Hypertension and Diastolic DysfunctionNCT00523549 · 2006-11-01
COMPLETEDSimvastatin and Diastolic DysfunctionNCT01061450 · 2006-11-01
COMPLETEDMarkers of Oxidative Stress Diastolic DysfunctionNCT00846404 · 2006-07-01
UNKNOWNTo Find Out Whether Valsartan With or Without Other Blood Pressure Medications Would Improve the Ability of the Heart to Fill and Empty, and the Ability of the Heart Muscle to Relax Adequately in People With High Blood Pressure.NCT00170924 · 2004-08-01
COMPLETEDCommon interventions
LiraglutideDRUG3PlaceboDRUG3EchocardiographyDIAGNOSTIC_TEST2Liraglutide - PlaceboDRUG2valsartanDRUG2abdominal plastic interventionPROCEDURE1Adjustment of lower rate limitDEVICE1aerobic exerciseOTHER1amlodipineDRUG1As needed pharmacological rate control with beta-blocker (metoprolol tartrate, metoprolol succinate) or calcium channel blocker (diltiazem, verapamil)DRUG1Bedside EchocardiographyDIAGNOSTIC_TEST1Bedside Echocardiography_1DIAGNOSTIC_TEST1Bedside Echocardiography_2DIAGNOSTIC_TEST1Bedside Echocardiography_3DIAGNOSTIC_TEST1Bedside Echocardiography_4DIAGNOSTIC_TEST1Cardiac Assessments and Eye AssessmentsDIAGNOSTIC_TEST1Cardiac MRI/MRSOTHER1Ciprofibrate 100Mg TabletDRUG1combined exerciseOTHER1cool hemodialysisDEVICE1CORolla™ TAA deviceDEVICE1Coronary flow reserve and index of microcirculatory dysfunctionDIAGNOSTIC_TEST1Diastolic function evaluationDIAGNOSTIC_TEST1DiastologyDIAGNOSTIC_TEST1Diastology-Guided DiuresisBEHAVIORAL1
Leading sponsors
University of Aarhus
3
Assiut University
2
Leiden University Medical Center
2
Umeå University
2
University of Vermont
2
Academisch Ziekenhuis Maastricht
1
Amsterdam UMC, location VUmc
1
Brasilia Heart Study Group
1
Centro Hospitalar de Lisboa Central
1
Copenhagen University Hospital, Rigshospitalet
1
CorAssist Cadiovascular Ltd.
1
Duke University
1
Emory University
1
Evangelismos Hospital
1
Heinrich-Heine University, Duesseldorf
1
Trial status mix
COMPLETED27
UNKNOWN12
TERMINATED4
ACTIVE_NOT_RECRUITING2
NOT_YET_RECRUITING2
ENROLLING_BY_INVITATION1
RECRUITING1
WITHDRAWN1
Phase mix
NA11
PHASE49
PHASE25
PHASE12
PHASE31
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Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.