Condition

Heart Failure, Systolic

ClinicalTrials.gov condition label

How to interpret these research links

Connected source records

This is the original ClinicalTrials.gov condition label, found in 125 distinct published trials. It is kept separate from a MONDO disease identifier until a specific normalization is supported. Related interventions are co-recorded in studies; they are not medical recommendations.

Data basis: current published ClinicalTrials.gov records and, where present, RxNorm, MONDO and FDA-label identifiers. See the evidence interpretation and counting methodology.

Clinical trials125

Recruiting11

Common interventions25

Lead sponsors shown15

Clinical trials

60 shown

A Study of LY3971297 in Participants With Heart FailureNCT07547540 · 2026-08-11

Comparative Efficacy and Safety of Acetazolamide Versus Metolazone as an Adjunct to Standard Therapy in Patients With Acute Decompensated Heart FailureNCT07199088 · 2025-10-11

Cardiac Performance During Steep Trendelenburg Position in Patients Undergoing Robotic Surgery Surgery.NCT06336746 · 2024-11-21

Paced Heart Rate Acceleration for Cardiac ConditioningNCT06332391 · 2024-06-26

Atrial Appendage Micrograft Transplants to Assist Heart Repair After Cardiac SurgeryNCT05632432 · 2024-04-01

Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness StatusNCT06009276 · 2023-08-30

Diuretics Alone vs. Aortix Endovascular Device for Acute Heart FailureNCT05677100 · 2023-08-23

ConTempoRary Cardiac Stimulation in Clinical practicE: lEft, BivEntriculAr, Right, and conDuction System PacingNCT06324682 · 2023-01-01

Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection FractionNCT04703842 · 2021-09-23

Prevalence and Risk Factors asSOciated With CArdiac comorbiDIty in psoriAsisNCT04950218 · 2021-09-01

Mechanistic Clinical Trial of Advanced Imaging for CRTNCT03398369 · 2018-01-05

Pharmacist-Assisted Titration of Rx to Implement Optimal Medical Therapy for Heart FailureNCT07714239 · 2026-11-01

NOT_YET_RECRUITING

Short-Term Outcomes of HFrEF Patients on Guideline-Directed Medical TherapyNCT07821801 · 2026-09-10

NOT_YET_RECRUITING

HeartMate App-Based Remote Monitoring for Cardiovascular Risk Factor ManagementNCT07721584 · 2026-07-14

NOT_YET_RECRUITING

Pilot Study of StudyU for N-of-1 Trials in HFrEF Patients (N-of-1 App)NCT07252310 · 2026-02-10

ENROLLING_BY_INVITATION

Digoxin and Senolysis in Heart Failure and Diabetes MellitusNCT06240403 · 2025-09-01

NOT_YET_RECRUITING

The Correlation Between Serum PRMT5 Level and Cardiac Ultrasound Indicators in Patients With Heart FailureNCT07050706 · 2025-01-01

ENROLLING_BY_INVITATION

Digital Remote Home Monitoring for Heart FailureNCT05988749 · 2024-12-13

Non-interventional Study on Guideline Directed Medical Therapy for Patients With Heart Failure (HF) in GermanyNCT06675552 · 2024-11-15

ACTIVE_NOT_RECRUITING

PhotobiomoduLation for pAtientS With Advanced hEart failuReNCT06501313 · 2024-08-01

IV Iron and SGLT2 Inhibitor on Ventricular Function and Myocardial Iron Content in Heart Failure With Iron DeficiencyNCT06434025 · 2024-05-24

NOT_YET_RECRUITING

Beneficial Effects of Vitamin D Combined With Oral Iron Supplementation in Patients With Chronic Heart Failure and Iron DeficiencyNCT05702970 · 2024-01-15

Physiological Effects of Lactate in Individuals With Chronic Heart FailureNCT06121323 · 2023-11-22

MCNAIR Study: coMparative effeCtiveness of iN-person and teleheAlth cardIac RehabilitationNCT05933083 · 2023-10-27

ACTIVE_NOT_RECRUITING

Clinical Trial of Human Allogenic Culture-expanded Bone Marrow-derived Mesenchymal Stem CellsNCT05925608 · 2023-08-23

ACTIVE_NOT_RECRUITING

HIDRAdenitis Suppurativa and HEART DiseaseNCT05989945 · 2023-08-01

ACTIVE_NOT_RECRUITING

Financial Support in an Underserved and Low-Income Population With Heart FailureNCT05928026 · 2023-06-09

Effects of CRT Optimization as Assessed by Cardiac MRNCT04763460 · 2023-06-01

Pilot Study Lp299v Supplementation in Chronic Heart FailureNCT05752760 · 2023-02-20

Cardiac Structure and Function in Patients with Cystic FibrosisNCT06084468 · 2023-01-01

ACTIVE_NOT_RECRUITING

Machine Learning Enabled Time Series Analysis in MedicineNCT05802563 · 2022-05-24

Safety and Efficacy Study of AI LVEFNCT05140642 · 2022-04-01

Levosimendan In Ambulatory Heart Failure PatientsNCT04705337 · 2021-12-15

Robotic-assisted Exercise Training in Heart Failure With Reduced Ejection FractionNCT05278429 · 2021-11-01

TRANSFORM Heart Failure with Reduced Ejection FractionNCT04872959 · 2021-10-22

Network Medicine Approaches to Classify Heart Failure With PReserved Ejection Fraction by Signatures of DNA Methylation and Point-of-carE Risk calculaTors (PRESMET)NCT05475028 · 2021-09-14

Acute Hemodynamic Effects of Pacing the His Bundle in Heart FailureNCT04701112 · 2021-09-01

Multi-intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells in Heart Failure With Reduced Ejection Fraction（PRIME-HFrEF Study）NCT04992832 · 2021-07-28

Cardiac Output in Heart Failure Patients With Mechanical PumpsNCT05195931 · 2021-06-08

Robotic-assisted Exercise Training in Heart FailureNCT04839133 · 2021-03-31

Sacubitril/Valsartan Versus Valsartan in Heart Failure With Improved Ejection FractionNCT04803175 · 2021-03-16

Observational and Prospective Registry on Cardiac Contractility Modulation (CCM) TherapyNCT04902079 · 2021-03-08

Effects of Ketones and Niacin in Heart Failure PatientsNCT04703361 · 2021-02-15

Hypoxic Conditioning in Heart FailureNCT03537079 · 2021-02-05

The Aortix CRS Pilot StudyNCT04145635 · 2021-02-05

Prospective Monitoring of Angiotensin Receptor Neprilysin Inhibitor in Older Adults With Heart Failure and FrailtyNCT04743063 · 2021-01-14

Evaluating Infrasonic HemodynographyNCT04636892 · 2021-01-04

The Relationship Between Inflammatory ARTritis and CArdiac DIseAseNCT05647577 · 2021-01-01

ACTIVE_NOT_RECRUITING

Safety and Tolerability of Sacubitril/Valsartan in Heart Failure Patient With Reduced Ejection FractionNCT05387967 · 2021-01-01

Apple-CPET Ted Rogers Understanding Exacerbations of Heart FailureNCT05008692 · 2020-12-01

Dapagliflozin And Pulmonary Artery Hemodynamics in Heart Failure With Reduced Ejection Fraction Patients With CardioMEMS®NCT04570865 · 2020-12-01

His-bundle Pacing vs. Right Ventricular Apical Pacing in Patients With Reduced Ejection FractionNCT04529577 · 2020-12-01

The Fluoroless-CSP Trial Using Electroanatomic MappingNCT03903107 · 2020-10-26

Mechanistic Studies of Nicotinamide Riboside in Human Heart FailureNCT04528004 · 2020-09-26

ACTIVE_NOT_RECRUITING

Electrostimulation of Skeletal Muscles in Patients Listed for a Heart TransplantNCT04522609 · 2020-09-01

Physiological Signals, Activity and Posture for Surface Mounted Insertable Cardiac Monitor in Heart Failure StudyNCT04112576 · 2020-07-23

Cryoballoon Ablation Versus Medical Therapy in Patients With Heart Failure and Atrial FibrillationNCT04342832 · 2020-07-16

Balance, Aerobic Capacity, Mobility and Strength in Patients Hospitalized for Heart Failure (BAMS-HF) ProgramNCT04281849 · 2020-06-15

Optimising Pacing for Contractility 2NCT04201015 · 2020-06-01

Integrated Distance Management Strategy for Patients With Cardiovascular Diseases in the Context of COVID-19NCT04325867 · 2020-03-31

Common interventions

Leading sponsors

University of Leeds 5 Virginia Commonwealth University 4 Herlev and Gentofte Hospital 3 University of Colorado, Denver 3 Aarhus University Hospital 2 BioCardia, Inc. 2 Boston Scientific Corporation 2 German Heart Institute 2 Henrik Wiggers 2 Hospital de Clinicas de Porto Alegre 2 Novartis Pharmaceuticals 2 Oslo University Hospital 2 Procyrion 2 Queen's University 2 Region Skane 2

Trial status mix

COMPLETED50

UNKNOWN30

TERMINATED12

RECRUITING11

ACTIVE_NOT_RECRUITING7

WITHDRAWN7

NOT_YET_RECRUITING5

ENROLLING_BY_INVITATION2

SUSPENDED1

Phase mix

NA56

PHASE216

PHASE413

PHASE18

PHASE38

EARLY_PHASE11

Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.