Condition

Heart Failure With Reduced Ejection Fraction

ClinicalTrials.gov condition label

How to interpret these research links

Connected source records

This is the original ClinicalTrials.gov condition label, found in 215 distinct published trials. It is kept separate from a MONDO disease identifier until a specific normalization is supported. Related interventions are co-recorded in studies; they are not medical recommendations.

Data basis: current published ClinicalTrials.gov records and, where present, RxNorm, MONDO and FDA-label identifiers. See the evidence interpretation and counting methodology.

Clinical trials215
Recruiting40
Common interventions25
Lead sponsors shown15
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Clinical trials

60 shown
Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic ScoreNCT07490067 · 2026-10-01
RECRUITING
A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart DiseaseNCT07214376 · 2026-08-21
RECRUITING
HFrEF Polypill in Sri Lanka RCTNCT07569640 · 2026-08-17
RECRUITING
STEPwise De-escalation and Optimizing Withdrawal of ARNI and SGLT2i in Normalized Heart FailureNCT07631156 · 2026-08-12
RECRUITING
Midodrine in Heart Failure With Reduced Ejection Fraction With HypotensionNCT06405555 · 2026-08-07
RECRUITING
Synchronized Diaphragmatic Stimulation in Symptomatic Heart FailureNCT06552637 · 2026-07-08
RECRUITING
Lumacaftor Yields Reversal of Impaired Cerebral Blood Flow in Heart Failure PatientsNCT07695090 · 2026-07-01
RECRUITING
A Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection FractionNCT07465653 · 2026-03-18
RECRUITING
Digital Remote Management Versus Usual Care for Optimization of Guideline-directed Medical Therapy in Patients With Heart Failure and Reduced Ejection Fraction: a Multicentre, Randomised, Controlled Trial (DigiCare-HFrEF)NCT07352891 · 2026-02-26
RECRUITING
High Fat Diet for Cardiac Metabolic ReprogrammingNCT06747429 · 2026-01-15
RECRUITING
Digital Support Program for Patients With Heart Failure - a Cluster-Randomized Hybrid Type 2 StudyNCT07275931 · 2025-12-15
RECRUITING
A Study Investigating the Impact of IMT With CR On Exercise Responses In HFNCT07086131 · 2025-09-04
RECRUITING
Digital Solutions in Heart Therapy (DIGNITY)NCT06942221 · 2025-07-17
RECRUITING
Deep Learning Detection of Pulmonary Hypertension and Low Ejection Fraction Via Digital Stethoscope and 3-Lead ECGNCT07087613 · 2025-06-15
RECRUITING
Study Assessing Left Ventricular Administration of a Genetic Medicine Directing Organ Regeneration in Heart FailureNCT06831825 · 2025-04-23
RECRUITING
Efficacy of Remote Monitoring of Patients With Heart Failure and Reduced Ejection Fraction by Using Caaring® SoftwareNCT06920160 · 2025-04-15
RECRUITING
Implementation and Interaction of Clinician And Patient-facing Tools Aiming to Intensify Neurohormonal Medicines for Heart FailureNCT06526988 · 2025-03-06
RECRUITING
Withdrawal of Treatment for Heart Failure Patients With Recovery From Tachycardia-induced CardiomyopathyNCT06128980 · 2025-01-09
RECRUITING
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection FractionNCT06736574 · 2024-12-19
RECRUITING
The CardioClip StudyNCT06241430 · 2024-12-18
RECRUITING
Hemodynamic Assessment of underLying myocyTe Function in Right Heart FailureNCT06299436 · 2024-12-10
RECRUITING
Vsling™ I: Clinical Evaluation of the Vsling™ Device for Ventricular Repair in Patients With Heart FailureNCT06851949 · 2024-11-15
RECRUITING
Respiratory Sinus Arrhythmia Pacing Post-CABG Surgery in Patients With HFrEFNCT06384963 · 2024-09-02
RECRUITING
Mobile Applet for Weight Management in Obese Heart Failure PatientsNCT06455878 · 2024-06-06
RECRUITING
Colchicine in Acutely Decompensated HFREFNCT06286423 · 2024-06-01
RECRUITING
Effect of Weight Loss on Physical and Cardiac Performance in People With Obesity and Heart FailureNCT06423599 · 2024-04-30
RECRUITING
Ketones, SGLT2, HFrEFNCT06229678 · 2024-01-25
RECRUITING
Pulmonary Artery Catheterization and Carvedilol Early Initiation in Cardiogenic SHOCK Due to HFrEFNCT06078436 · 2024-01-01
RECRUITING
Improving CRT Outcome With Non-Invasive Cardiac MappingNCT05564793 · 2023-12-20
RECRUITING
Exercise Capacity Improvement by Conduction System Pacing in heArt Failure patieNts Without Compelling CRT inDicationNCT06278844 · 2023-12-12
RECRUITING
Conduction System Vs Surgical Left Ventricular Epicardial Pacing For Coronary Sinus Lead FailureNCT06342492 · 2023-11-07
RECRUITING
Left vs Left Randomized Clinical TrialNCT05650658 · 2023-09-13
RECRUITING
Demographic, Clinical, Biological, Treatment Characteristics and Cardiovascular Events of Patients With Heart Failure in Vietnam: a Multicenter Prospective Observational StudyNCT06516562 · 2023-08-01
RECRUITING
Revascularization Versus Medical Treatment in Patients With Ischemic Left Ventricular DysfunctionNCT05828719 · 2023-06-16
RECRUITING
The Effect of Obesity and Weight Loss in Heart Failure With Reduced Ejection Fraction.NCT05942287 · 2023-05-24
RECRUITING
Dietary Intervention and Physical Activity in Patients With Heart Failure and Reduced Ejection FractionNCT07595809 · 2023-05-08
RECRUITING
Yoga Based Cardiac Rehabilitation in Heart Failure FailureNCT07817589 · 2023-04-24
RECRUITING
PRIME HFrEF: Novel Exercise for Older Patients With Heart Failure With Reduced Ejection FractionNCT05609097 · 2023-04-14
RECRUITING
Real-Time Monitoring of Heart Failure Across the Yale New Haven Health SystemNCT04237701 · 2019-10-01
RECRUITING
Biomechanical Precision Medicine Registry for Patients With and Without Heart FailureNCT03480633 · 2016-04-07
RECRUITING
PCI With GDMT Versus GDMT Alone for Patients With Ischemic Cardiomyopathy and Reduced LVEFNCT07349979 · 2026-12-30
NOT_YET_RECRUITING
[11C]PS13 PET Imaging of Neuroinflammation in Heart Failure With Reduced Ejection FractionNCT07856043 · 2026-10-01
NOT_YET_RECRUITING
Utilization of Guided Point of Care Ultrasound in Heart Failure Diagnosis Pilot TrialNCT07828834 · 2026-09-30
NOT_YET_RECRUITING
Intermediate Outcomes of HFrEF Patients on Guideline-Directed Medical TherapyNCT07845201 · 2026-09-26
NOT_YET_RECRUITING
STRATegy SUccesS in High-Risk PCI With Impella CP: Evaluation of Hemodynamic Protection in Complex PCINCT07588399 · 2026-07-01
NOT_YET_RECRUITING
Circulating RNA Markers of Ventricular Arrhythmias in Remotely Monitored Patients With Post-Infarction Heart Failure and Implanted Cardioverter-DefibrillatorsNCT07795892 · 2026-03-12
ACTIVE_NOT_RECRUITING
A Real-world Study of Clinical Treatment Guidelines for Patients With Heart Failure With Reduced Ejection Fraction Treated With Sacubitril/ValsartanNCT07465679 · 2026-01-28
COMPLETED
Optimising Pacing Therapy, Integrated Medical Therapy, and Catheter AbLation for Atrial Fibrillation in Heart Failure TrialNCT07238452 · 2025-12-01
NOT_YET_RECRUITING
Evaluation of the HekaHeart Platform in Medication Management for Heart Failure PatientsNCT06433687 · 2025-10-01
WITHDRAWN
Pulsed Field or Cryoballoon Pulmonary Vein Isolation for Atrial Fibrillation in Heart FailureNCT07181291 · 2025-09-01
COMPLETED
An Early Feasibility Study Evaluation of an Implant Free Interatrial Shunt to Improve Heart FailureNCT06859970 · 2025-05-15
ACTIVE_NOT_RECRUITING
EHR Nudges to Improve Quality of Care in HFNCT06103565 · 2025-05-13
COMPLETED
Neuromuscular Fatigability in Individuals With Heart FailureNCT06551012 · 2025-05-01
NOT_YET_RECRUITING
Whole Heart Radiotherapy for End-stage Heart FailureNCT06299176 · 2025-04-30
ENROLLING_BY_INVITATION
Comparative Effectiveness of Prophylactic ICD Versus Non-ICD TherapyNCT06543446 · 2025-03-04
TERMINATED
Heart Failure With Reduced Ejection Fraction Polypill Implementation Strategy in Sri LankaNCT06831864 · 2025-02-15
COMPLETED
Subspecialty Ambulatory Quality Cardiology ProgramNCT07283666 · 2024-12-19
ENROLLING_BY_INVITATION
Respiratory Sinus Arrhythmia (RSA) Pacing Post-CABG Surgery in Patients With HFrEFNCT06359938 · 2024-11-22
COMPLETED
Emulation of the EMPEROR-Reduced Trial Using Healthcare Claims DataNCT07599345 · 2024-10-13
COMPLETED
VITAL - the Heart Failure With Reduced Ejection Fraction Sub-studyNCT06534151 · 2024-10-01
NOT_YET_RECRUITING

Common interventions

Trial status mix

COMPLETED80
UNKNOWN52
RECRUITING40
TERMINATED12
NOT_YET_RECRUITING11
ACTIVE_NOT_RECRUITING9
WITHDRAWN8
ENROLLING_BY_INVITATION3

Phase mix

NA88
PHASE425
PHASE220
PHASE113
PHASE311
EARLY_PHASE12
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Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.