Condition
Heart Failure With Reduced Ejection Fraction
ClinicalTrials.gov condition label
How to interpret these research links
Connected source recordsThis is the original ClinicalTrials.gov condition label, found in 215 distinct published trials. It is kept separate from a MONDO disease identifier until a specific normalization is supported. Related interventions are co-recorded in studies; they are not medical recommendations.
Data basis: current published ClinicalTrials.gov records and, where present, RxNorm, MONDO and FDA-label identifiers. See the evidence interpretation and counting methodology.
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Clinical trials
60 shownMechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic ScoreNCT07490067 · 2026-10-01
RECRUITINGA Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart DiseaseNCT07214376 · 2026-08-21
RECRUITINGHFrEF Polypill in Sri Lanka RCTNCT07569640 · 2026-08-17
RECRUITINGSTEPwise De-escalation and Optimizing Withdrawal of ARNI and SGLT2i in Normalized Heart FailureNCT07631156 · 2026-08-12
RECRUITINGMidodrine in Heart Failure With Reduced Ejection Fraction With HypotensionNCT06405555 · 2026-08-07
RECRUITINGSynchronized Diaphragmatic Stimulation in Symptomatic Heart FailureNCT06552637 · 2026-07-08
RECRUITINGLumacaftor Yields Reversal of Impaired Cerebral Blood Flow in Heart Failure PatientsNCT07695090 · 2026-07-01
RECRUITINGA Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection FractionNCT07465653 · 2026-03-18
RECRUITINGDigital Remote Management Versus Usual Care for Optimization of Guideline-directed Medical Therapy in Patients With Heart Failure and Reduced Ejection Fraction: a Multicentre, Randomised, Controlled Trial (DigiCare-HFrEF)NCT07352891 · 2026-02-26
RECRUITINGHigh Fat Diet for Cardiac Metabolic ReprogrammingNCT06747429 · 2026-01-15
RECRUITINGDigital Support Program for Patients With Heart Failure - a Cluster-Randomized Hybrid Type 2 StudyNCT07275931 · 2025-12-15
RECRUITINGA Study Investigating the Impact of IMT With CR On Exercise Responses In HFNCT07086131 · 2025-09-04
RECRUITINGDigital Solutions in Heart Therapy (DIGNITY)NCT06942221 · 2025-07-17
RECRUITINGDeep Learning Detection of Pulmonary Hypertension and Low Ejection Fraction Via Digital Stethoscope and 3-Lead ECGNCT07087613 · 2025-06-15
RECRUITINGStudy Assessing Left Ventricular Administration of a Genetic Medicine Directing Organ Regeneration in Heart FailureNCT06831825 · 2025-04-23
RECRUITINGEfficacy of Remote Monitoring of Patients With Heart Failure and Reduced Ejection Fraction by Using Caaring® SoftwareNCT06920160 · 2025-04-15
RECRUITINGImplementation and Interaction of Clinician And Patient-facing Tools Aiming to Intensify Neurohormonal Medicines for Heart FailureNCT06526988 · 2025-03-06
RECRUITINGWithdrawal of Treatment for Heart Failure Patients With Recovery From Tachycardia-induced CardiomyopathyNCT06128980 · 2025-01-09
RECRUITINGStudy With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection FractionNCT06736574 · 2024-12-19
RECRUITINGThe CardioClip StudyNCT06241430 · 2024-12-18
RECRUITINGHemodynamic Assessment of underLying myocyTe Function in Right Heart FailureNCT06299436 · 2024-12-10
RECRUITINGVsling™ I: Clinical Evaluation of the Vsling™ Device for Ventricular Repair in Patients With Heart FailureNCT06851949 · 2024-11-15
RECRUITINGRespiratory Sinus Arrhythmia Pacing Post-CABG Surgery in Patients With HFrEFNCT06384963 · 2024-09-02
RECRUITINGMobile Applet for Weight Management in Obese Heart Failure PatientsNCT06455878 · 2024-06-06
RECRUITINGColchicine in Acutely Decompensated HFREFNCT06286423 · 2024-06-01
RECRUITINGEffect of Weight Loss on Physical and Cardiac Performance in People With Obesity and Heart FailureNCT06423599 · 2024-04-30
RECRUITINGKetones, SGLT2, HFrEFNCT06229678 · 2024-01-25
RECRUITINGPulmonary Artery Catheterization and Carvedilol Early Initiation in Cardiogenic SHOCK Due to HFrEFNCT06078436 · 2024-01-01
RECRUITINGImproving CRT Outcome With Non-Invasive Cardiac MappingNCT05564793 · 2023-12-20
RECRUITINGExercise Capacity Improvement by Conduction System Pacing in heArt Failure patieNts Without Compelling CRT inDicationNCT06278844 · 2023-12-12
RECRUITINGConduction System Vs Surgical Left Ventricular Epicardial Pacing For Coronary Sinus Lead FailureNCT06342492 · 2023-11-07
RECRUITINGLeft vs Left Randomized Clinical TrialNCT05650658 · 2023-09-13
RECRUITINGDemographic, Clinical, Biological, Treatment Characteristics and Cardiovascular Events of Patients With Heart Failure in Vietnam: a Multicenter Prospective Observational StudyNCT06516562 · 2023-08-01
RECRUITINGRevascularization Versus Medical Treatment in Patients With Ischemic Left Ventricular DysfunctionNCT05828719 · 2023-06-16
RECRUITINGThe Effect of Obesity and Weight Loss in Heart Failure With Reduced Ejection Fraction.NCT05942287 · 2023-05-24
RECRUITINGDietary Intervention and Physical Activity in Patients With Heart Failure and Reduced Ejection FractionNCT07595809 · 2023-05-08
RECRUITINGYoga Based Cardiac Rehabilitation in Heart Failure FailureNCT07817589 · 2023-04-24
RECRUITINGPRIME HFrEF: Novel Exercise for Older Patients With Heart Failure With Reduced Ejection FractionNCT05609097 · 2023-04-14
RECRUITINGReal-Time Monitoring of Heart Failure Across the Yale New Haven Health SystemNCT04237701 · 2019-10-01
RECRUITINGBiomechanical Precision Medicine Registry for Patients With and Without Heart FailureNCT03480633 · 2016-04-07
RECRUITINGPCI With GDMT Versus GDMT Alone for Patients With Ischemic Cardiomyopathy and Reduced LVEFNCT07349979 · 2026-12-30
NOT_YET_RECRUITING[11C]PS13 PET Imaging of Neuroinflammation in Heart Failure With Reduced Ejection FractionNCT07856043 · 2026-10-01
NOT_YET_RECRUITINGUtilization of Guided Point of Care Ultrasound in Heart Failure Diagnosis Pilot TrialNCT07828834 · 2026-09-30
NOT_YET_RECRUITINGIntermediate Outcomes of HFrEF Patients on Guideline-Directed Medical TherapyNCT07845201 · 2026-09-26
NOT_YET_RECRUITINGSTRATegy SUccesS in High-Risk PCI With Impella CP: Evaluation of Hemodynamic Protection in Complex PCINCT07588399 · 2026-07-01
NOT_YET_RECRUITINGCirculating RNA Markers of Ventricular Arrhythmias in Remotely Monitored Patients With Post-Infarction Heart Failure and Implanted Cardioverter-DefibrillatorsNCT07795892 · 2026-03-12
ACTIVE_NOT_RECRUITINGA Real-world Study of Clinical Treatment Guidelines for Patients With Heart Failure With Reduced Ejection Fraction Treated With Sacubitril/ValsartanNCT07465679 · 2026-01-28
COMPLETEDOptimising Pacing Therapy, Integrated Medical Therapy, and Catheter AbLation for Atrial Fibrillation in Heart Failure TrialNCT07238452 · 2025-12-01
NOT_YET_RECRUITINGEvaluation of the HekaHeart Platform in Medication Management for Heart Failure PatientsNCT06433687 · 2025-10-01
WITHDRAWNPulsed Field or Cryoballoon Pulmonary Vein Isolation for Atrial Fibrillation in Heart FailureNCT07181291 · 2025-09-01
COMPLETEDAn Early Feasibility Study Evaluation of an Implant Free Interatrial Shunt to Improve Heart FailureNCT06859970 · 2025-05-15
ACTIVE_NOT_RECRUITINGEHR Nudges to Improve Quality of Care in HFNCT06103565 · 2025-05-13
COMPLETEDNeuromuscular Fatigability in Individuals With Heart FailureNCT06551012 · 2025-05-01
NOT_YET_RECRUITINGWhole Heart Radiotherapy for End-stage Heart FailureNCT06299176 · 2025-04-30
ENROLLING_BY_INVITATIONComparative Effectiveness of Prophylactic ICD Versus Non-ICD TherapyNCT06543446 · 2025-03-04
TERMINATEDHeart Failure With Reduced Ejection Fraction Polypill Implementation Strategy in Sri LankaNCT06831864 · 2025-02-15
COMPLETEDSubspecialty Ambulatory Quality Cardiology ProgramNCT07283666 · 2024-12-19
ENROLLING_BY_INVITATIONRespiratory Sinus Arrhythmia (RSA) Pacing Post-CABG Surgery in Patients With HFrEFNCT06359938 · 2024-11-22
COMPLETEDEmulation of the EMPEROR-Reduced Trial Using Healthcare Claims DataNCT07599345 · 2024-10-13
COMPLETEDVITAL - the Heart Failure With Reduced Ejection Fraction Sub-studyNCT06534151 · 2024-10-01
NOT_YET_RECRUITINGCommon interventions
PlaceboDRUG14Empagliflozin 10 mgDRUG3GDMTDRUG3PlaceboOTHER3Sacubitril-ValsartanDRUG3usual careOTHER3Atrial pacing with respiratory sinus arrhythmia (RSA) variabilityDEVICE2Best Practice Alert (BPA)OTHER2BisoprololDRUG2Cardiac MRIDIAGNOSTIC_TEST2HFrEF PolypillDRUG2In-Basket MessageOTHER2JK07DRUG2LCZ696DRUG2left bundle branch area pacingDEVICE2LevosimendanDRUG2Monotonic right atrial overdrive pacingDEVICE2Percutaneous coronary interventionPROCEDURE2PlaceboDIETARY_SUPPLEMENT2SpironolactoneDRUG2Synchronized Diaphragmatic StimulationDEVICE2TVSDEVICE2[11C]PS13: [carbon-11]PS13; COX-1 PET radioligandDRUG125 mg Omecamtiv MecarbilDRUG13-hydroxybutyratDIETARY_SUPPLEMENT1
Leading sponsors
Novartis Pharmaceuticals
5
Yale University
4
Cytokinetics
3
Duke University
3
NYU Langone Health
3
University of Virginia
3
Alexandria University
2
Assiut University
2
Brigham and Women's Hospital
2
Bristol-Myers Squibb
2
Cairo University
2
Cardurion Pharmaceuticals, Inc.
2
Chongqing Medical University
2
Copenhagen University Hospital, Rigshospitalet
2
Linkoeping University
2
Trial status mix
COMPLETED80
UNKNOWN52
RECRUITING40
TERMINATED12
NOT_YET_RECRUITING11
ACTIVE_NOT_RECRUITING9
WITHDRAWN8
ENROLLING_BY_INVITATION3
Phase mix
NA88
PHASE425
PHASE220
PHASE113
PHASE311
EARLY_PHASE12
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Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.