Condition

Mitral Regurgitation

ClinicalTrials.gov condition label

How to interpret these research links

Connected source records

This is the original ClinicalTrials.gov condition label, found in 43 distinct published trials. It is kept separate from a MONDO disease identifier until a specific normalization is supported. Related interventions are co-recorded in studies; they are not medical recommendations.

Data basis: current published ClinicalTrials.gov records and, where present, RxNorm, MONDO and FDA-label identifiers. See the evidence interpretation and counting methodology.

Clinical trials43

Recruiting2

Common interventions25

Lead sponsors shown15

Clinical trials

43 shown

The CardioClip StudyNCT06241430 · 2024-12-18

Efficacy of MitraCLip Vs. PASCAL for the TrEAtment of MitraL REgurgiTation in an All-comer PopulationNCT06634121 · 2024-04-01

LEFT ATRIAL MONITORING IN PATIENTS BEFORE AND AFTER MITRAL SURGERY - LAMBDA STUDYNCT06547788 · 2026-09-30

NOT_YET_RECRUITING

Importance of Point-of-Care Ultrasound for Early Detection of Valvular and Cardiac Diseases (IMPROVE)NCT07756398 · 2026-08-01

NOT_YET_RECRUITING

Optimization of Heart Failure (HF) Medical Therapy After Transcatheter Valve Intervention (TVI) in Patients With Heart Failure With Reduced Ejection Fraction (HFrEF)NCT06667128 · 2025-02-01

NOT_YET_RECRUITING

MitraClip in Patients With Heart FailureNCT06633159 · 2024-04-15

Development and Validation of the Prediction Model for Functional Mitral Regurgitation Regression in Heart Failure Patients Taking Guideline-directed Medical TherapyNCT06278727 · 2024-01-01

Munich Transcatheter Mitral Valve Safety and EffectivenessNCT05871983 · 2023-07-30

NOT_YET_RECRUITING

The China Mviv RegistryNCT05925335 · 2023-07-11

Early Discharge After Mitral and Tricuspid Edge-to-edge Repair: an Assessment of Feasibility and SafetyNCT06343363 · 2023-05-01

Structural Mitral Valve ProjectNCT05678868 · 2022-02-01

Mitral Regurgitation Treatment in Advanced Heart FailureNCT05292716 · 2021-04-21

Implantation of a Permanent Interatrial Shunt to Reduce Left Atrial Filling Pressures Following MitraClipNCT04729933 · 2021-03-11

ACTIVE_NOT_RECRUITING

In Search of Best Practices for Patients With Heart Failure and Secondary Mitral Regurgitation: An Evaluation of the Inova Heart Failure Treatment AlgorithmNCT06675448 · 2021-01-28

Evaluating Infrasonic HemodynographyNCT04636892 · 2021-01-04

MitraClip for the Treatment of Moderate Functional Mitral Regurgitation: EVOLVE-MRNCT03705312 · 2019-02-22

Transcatheter Mitral Valve Repair as Bridge Therapy to Heart TransplantationNCT04293575 · 2018-06-01

Strain Imaging in Patients With Functional Mitral Regurgitation, Treated With MitraClipNCT04218578 · 2018-05-10

AHEAD: European Feasibility Study of the Cardiovalve Transfemoral Mitral Valve SystemNCT03339115 · 2018-04-23

ACTIVE_NOT_RECRUITING

Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional MRNCT07227675 · 2017-10-23

Cardiovalve Transfemoral System - FIM StudyNCT03958773 · 2017-10-12

ENROLLING_BY_INVITATION

Caisson Transcatheter Mitral Valve Replacement (TMVR)NCT03661398 · 2017-07-20

Edwards Cardioband System ACTIVE Pivotal Clinical Trial (ACTIVE)NCT03016975 · 2017-06-01

The Right Ventricular Pulmonary Circulation Continuum in Mitral Valve Disease StudyNCT03155373 · 2017-02-15

The Prognostic Impact of Using High-dose Hydralazine in Severe Systolic Heart Failure With Hemodynamically Significant Mitral RegurgitationNCT04217135 · 2017-01-01

A Feasibility Registry of Actigraphy Monitoring in Degenerative Mitral Regurgitation Subjects Receiving the MitraClip® DeviceNCT02858245 · 2016-11-01

Incidence of Significant Mitral Regurgitation in Acute Heart Failure PatientsNCT02728739 · 2016-06-06

Remote Monitoring of Patients With Functional Mitral Regurgitation Undergoing Mitraclip Transcatheter RepairNCT02698150 · 2016-03-01

Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation (The COAPT Trial) and COAPT CASNCT01626079 · 2012-08-01

MitraClip System in Australia and New ZealandNCT01301625 · 2011-11-01

Identifying an Ideal Cardiopulmonary Exercise Test ParameterNCT01162083 · 2010-10-01

Safety and Efficacy Study of the PTMA Device to Reduce Mitral Valve Regurgitation in Patients With Heart FailureNCT00815386 · 2009-02-01

Real World Expanded Multicenter Study of the MitraClip® System (REALISM)NCT01931956 · 2009-01-22

Study of Safety and Efficacy of the Percutaneous Reduction of Mitral Valve Regurgitation in Heart Failure PatientsNCT00787293 · 2008-10-01

Cardiac Output Pulmonary Arterial Catheter Compared to FloWave™ 1000NCT00665301 · 2008-03-01

Speckle Tracking Imaging and Realtime 3 Dimensional Echocardiograhy to Study LV Function and Remodeling After Acute Myocardial Infarction (AMI)NCT00745680 · 2007-10-01

EVEREST II Pivotal Study High Risk Registry (HRR)NCT01940120 · 2007-02-01

Aachen Safety and Efficacy of the Percutaneous Transvenous Mitral Annuloplasty Device to Reduce Mitral RegurgitationNCT00572091 · 2007-02-01

Montreal Safety and Efficacy of the Percutaneous Transvenous Mitral Annuloplasty DeviceNCT00571610 · 2006-04-01

Safety and Efficacy of the Percutaneous Transvenous Mitral Annuloplasty Device to Reduce Mitral RegurgitationNCT00568230 · 2006-04-01

Pivotal Study of a Percutaneous Mitral Valve Repair SystemNCT00209274 · 2005-08-01

Feasibility Study of a Percutaneous Mitral Valve Repair System.NCT00209339 · 2003-07-01

Effect of Brief Nebulization of Milrinone on Pulmonary Arterial Pressure Before Cardiopulmonary Bypass on Mitral Valve Surgery PatientsNCT01621971 · 2003-01-01

Common interventions

MitraClipDEVICE4 PTMA (Percutaneous Transvenous Mitral Annuloplasty) ImplantDEVICE3 Percutaneous mitral valve repair using MitraClip implantDEVICE2 angiotensin-converting enzyme inhibitors/angiotensin II receptor blocker/angiotensin receptor-neprilysin inhibitorDRUG1 Cardiac catheterisationDIAGNOSTIC_TEST1 Cardiac MRIDIAGNOSTIC_TEST1 CardioMEMSDEVICE1 Cardiopulmonary exercise testingDIAGNOSTIC_TEST1 Cardiovalve Transfemoral Mitral ValveDEVICE1 Cardiovalve transfemoral Mitral valve systemDEVICE1 Early discharge protocolBEHAVIORAL1 Edwards Cardioband SystemDEVICE1 Elecsys® NT-proBNP - Roche DiagnosticsDIAGNOSTIC_TEST1 evidence-based medications vs. high-dose hydralazine + evidence-based medicationsDRUG1 Guideline Directed Medical TherapyDRUG1 Guideline-directed medical therapyOTHER1 HERMES tabletDEVICE1 inhaled milrinoneDRUG1 intravenous milrinoneDRUG1 Kosmos Torso-One AI-guided Point-of-Care Ultrasound (EchoNous, Inc.)DEVICE1 MindMics earbudOTHER1 MitraClip ImplantDEVICE1 MitraClip procedurePROCEDURE1 MitraClip SystemDEVICE1 MitraClip® implantDEVICE1

Leading sponsors

Abbott Medical Devices 8 Viacor 5 Cardiovalve Ltd. 2 Imperial College London 2 Azienda Ospedaliero, Ferrarotto Alessi 1 Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia 1 Caisson Interventional LLC 1 Columbia University 1 Edwards Lifesciences 1 Inova Health Care Services 1 IRCCS Ospedale San Raffaele 1 Kaohsiung Veterans General Hospital. 1 Konkuk University Medical Center 1 LMU Klinikum 1 Metanoic Health Ltd. 1

Trial status mix

COMPLETED16

UNKNOWN13

NOT_YET_RECRUITING4

TERMINATED3

ACTIVE_NOT_RECRUITING2

RECRUITING2

SUSPENDED2

ENROLLING_BY_INVITATION1

Phase mix

NA21

PHASE14

PHASE24

PHASE32

PHASE41

Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.