Condition
Negative Symptoms of Schizophrenia
ClinicalTrials.gov condition label
How to interpret these research links
Connected source recordsThis is the original ClinicalTrials.gov condition label, found in 9 distinct published trials. It is kept separate from a MONDO disease identifier until a specific normalization is supported. Related interventions are co-recorded in studies; they are not medical recommendations.
Data basis: current published ClinicalTrials.gov records and, where present, RxNorm, MONDO and FDA-label identifiers. See the evidence interpretation and counting methodology.
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Clinical trials
9 shownStudy to Evaluate Efficacy and Safety of Roluperidone in Adult Subjects With Negative Symptoms and Stable Positive Symptoms of Schizophrenia and to Evaluate the Relapse Rate of Roluperidone and Antipsychotic MedicationsNCT07565428 · 2026-04-23
RECRUITINGA Phase 1, MAD Study to Evaluate the Safety, Tolerability and Pharmacokinetics of LY03017NCT06980207 · 2025-05-01
NOT_YET_RECRUITINGPrecise Intervention Technology and Application of Low Intensity TUS on Negative Symptoms of SchizophreniaNCT05985993 · 2025-04-01
COMPLETEDEffect of Food and Age on the Pharmacokinetics of LY03017NCT06793995 · 2025-02-01
NOT_YET_RECRUITINGA Phase 1, SAD Study to Evaluate the Safety and Tolerability of LY03017NCT06388551 · 2024-05-10
UNKNOWNBerberine in Treating Negative Symptoms of Schizophrenia: Clinical Efficacy and MechanismsNCT07356765 · 2023-09-26
ENROLLING_BY_INVITATIONEfficacy and Mechanisms of Low-intensity Focused Ultrasound on Negative Symptoms in Patients With SchizophreniaNCT04620460 · 2020-08-05
UNKNOWNStudy to Evaluate Efficacy and Safety of Roluperidone (MIN-101) in Adult Patients With Negative Symptoms of SchizophreniaNCT03397134 · 2017-12-15
COMPLETEDSPD489 as Adjunctive Treatment in Adults With Negative Symptoms of SchizophreniaNCT01234298 · 2012-01-27
WITHDRAWNCommon interventions
LY03017DRUG3LY03017-PlaceboDRUG2PlaceboDRUG2aripiprazoleDRUG1BerberineDRUG1Low-intensity Focused Ultrasound(LIFUS)DEVICE1low-intensity transcranial ultrasound stimulation (TUS)DEVICE1olanzapineDRUG1Placebo Oral TabletDRUG1risperidoneDRUG1RoluperidoneDRUG1Roluperidone 32 mgDRUG1Roluperidone 64 mgDRUG1SPD489 High-DoseDRUG1SPD489 Low-DoseDRUG1
Leading sponsors
Trial status mix
COMPLETED2
NOT_YET_RECRUITING2
UNKNOWN2
ENROLLING_BY_INVITATION1
RECRUITING1
WITHDRAWN1
Phase mix
NA3
PHASE13
PHASE33
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Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.