Condition

Optic Neuritis

ClinicalTrials.gov condition label

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Search results distinguish clinical terminology from original registry names. Shared trial participation does not imply treatment or approval.

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Connected source records

This is the original ClinicalTrials.gov condition label, found in 36 distinct published trials. It is kept separate from a MONDO disease identifier until a specific normalization is supported. Related interventions are co-recorded in studies; they are not medical recommendations.

Data basis: current published ClinicalTrials.gov records and, where present, RxNorm, MONDO and FDA-label identifiers. See the evidence interpretation and counting methodology.

Clinical trials36

Recruiting6

Common interventions25

Lead sponsors shown15

Clinical trials

36 shown

Privosegtor Investigation in Optic Neuropathies Efficacy Evaluation ResearchNCT07623668 · 2026-05-28

Efgartigimod for the Treatment of Acute Optic NeuritisNCT06453694 · 2025-08-12

Light Stimulation to Improve Visual Function After Optic Neuritis in Persons with Multiple SclerosisNCT06389968 · 2024-08-01

Swiss Pediatric Inflammatory Brain Disease Registry (Swiss-Ped-IBrainD)NCT05017142 · 2020-04-14

Retinal Neuro-vascular Coupling in Patients With Multiple SclerosisNCT03401879 · 2018-02-01

Assessment of Clemastine Fumarate as a Remyelinating Agent in Acute Optic Neuritis (ReCOVER)NCT02521311 · 2017-02-28

Early Prediction of Outcomes Following Optic Neuritis: Development and Acceptability of a Prognostic ToolNCT07704294 · 2026-09-01

NOT_YET_RECRUITING

Fampridine-SR and Optic Neuritis RecoveryNCT04148781 · 2022-03-22

Identification of Retinal Perivascular Inflammation in Patients With Multiple Sclerosis Using Adaptive Optics (RETIMUS)NCT04289909 · 2020-12-01

Optical Coherence Tomography and Optic Neuritis Not Related to Multiple SclerosisNCT03963310 · 2020-09-14

Acute Optic Neuritis Network: an International Study That Invesitages Subjects With a First-ever Episode of Acute Inflammation of the Optic NerveNCT05605951 · 2020-08-15

Diagnosis of ON With or Without MS or NMOSDNCT04131764 · 2019-10-04

Effect of Transorbital Electrical STIMulation of Optic Nerve on Remyelination After an Acute Optic NeuritisNCT04042363 · 2019-07-10

Optic Neuritis Differential Diagnosis StudyNCT03370965 · 2019-06-07

The Effect of a Gluten Free Diet on the Permeability of the Blood Brain Barrier in Patients With CISNCT03451955 · 2018-01-19

3D FLAIR Versus Coronal T2-WI MRI in Detecting Optic Neuritis (FLACON)NCT04792866 · 2018-01-01

Post-COntrast 3D SE T1 Versus Coronal SE T1-WI MRI in Detecting Optic Neuritis (COCON)NCT04793087 · 2018-01-01

Pupillometry Dynamic Measures in Patients Without Ocular or Neurological DiseaseNCT02894281 · 2016-06-01

Linking Optic Nerve MRI and the Retinal Axonal Loss After Optic NeuritisNCT03651362 · 2016-02-01

Treatment of Optic Neuritis With Erythropoietin: a Randomised, Double-blind, Placebo-controlled TrialNCT01962571 · 2014-11-25

Amiloride Clinical Trial In Optic NeuritisNCT01802489 · 2013-02-01

Interest of Dynamic Measures of the Pupil in Optic NeuritisNCT02004054 · 2012-12-01

Optical Coherence Tomography in Multiple Sclerosis PatientsNCT01774123 · 2012-08-01

Optic Neuritis Recovery After Oral or IV CorticosteroidsNCT01524250 · 2012-03-01

Neuroprotection With Phenytoin in Optic NeuritisNCT01451593 · 2011-11-01

Ampyra for Optic Neuritis in Multiple SclerosisNCT01337986 · 2011-05-01

Lipoic Acid as a Treatment for Acute Optic NeuritisNCT01294176 · 2011-01-01

Visual Reconstitution Therapy After Optic NeuritisNCT01274702 · 2010-05-01

Neuroprotection and Repair in Optic NeuritisNCT01073813 · 2010-02-01

Simvastatin Treatment of Patients With Acute Optic NeuritisNCT00261326 · 2006-09-01

Safety and Efficacy Study of Erythropoietin as add-on Therapy of Methylprednisolone to Treat Acute Optic NeuritisNCT00355095 · 2006-08-01

Biobank For MS And Other Demyelinating DiseasesNCT00445367 · 2006-05-01

ACTIVE_NOT_RECRUITING

Induction Therapy With a Single High Dose Bolus of Intravenous Methotrexate With Leucovorin Rescue, Prior to Initiation of AVONEX® Treatment, in Patients Presenting With a First Acute Demyelinating Event.NCT00037115 · 2002-05-01

Long Term Study of Avonex Therapy Following a First Attack of Multiple SclerosisNCT00179478 · 2001-02-01

Optic Neuritis Treatment Trial (ONTT)NCT00000146 · 1988-07-01

Longitudinal Optic Neuritis Study (LONS)NCT00000147 · 1988-07-01

Common interventions

Mapped drugs appearing in these trials

Shared trial participation only; not evidence of efficacy or approval.

placebo6 methylprednisolone4 prednisone2 amiloride1 clemastine1 efgartigimod alfa1 epoetin alfa1 interferon beta-1a1 methotrexate1 minocycline1 phenytoin1 simvastatin1 thioctic acid1

Leading sponsors

Fondation Ophtalmologique Adolphe de Rothschild 5 National Eye Institute (NEI) 2 Accelerated Cure Project for Multiple Sclerosis 1 Anastasia Vishnevetsky, MD, MPH 1 Beth Israel Deaconess Medical Center 1 Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts 1 Courtney Casserly 1 Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecul 1 Friedemann Paul 1 Glostrup University Hospital, Copenhagen 1 Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH 1 Institut National de la Santé Et de la Recherche Médicale, France 1 Jagannadha R Avasarala 1 King's College London 1 London Health Sciences Centre 1

Trial status mix

COMPLETED18

UNKNOWN7

RECRUITING6

TERMINATED2

ACTIVE_NOT_RECRUITING1

NOT_YET_RECRUITING1

WITHDRAWN1

Phase mix

PHASE29

NA7

PHASE36

PHASE42

EARLY_PHASE11

PHASE11

Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.