Condition
Osteoarthritis, Knee
ClinicalTrials.gov condition label
How to interpret these research links
Connected source recordsThis is the original ClinicalTrials.gov condition label, found in 50 distinct published trials. It is kept separate from a MONDO disease identifier until a specific normalization is supported. Related interventions are co-recorded in studies; they are not medical recommendations.
Data basis: current published ClinicalTrials.gov records and, where present, RxNorm, MONDO and FDA-label identifiers. See the evidence interpretation and counting methodology.
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Clinical trials
50 shownAMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce PainNCT07509307 · 2026-04-20
RECRUITINGStudy to Evaluate the Performance of Navigated TKA With OrthoPilot® pheno4u TKA Level 1NCT06955481 · 2025-10-07
RECRUITINGSubcutaneous Tirzepatide Once-weekly in Patients With Obesity and Knee Osteoarthritis (STOP KNEE-OA)NCT06191848 · 2024-11-19
RECRUITINGKnee Osteoarthritis Treatment With Zilretta vs. Kenalog in the Context of Type II DiabetesNCT06478186 · 2024-08-16
RECRUITINGComparative Study of Navigation-assisted OrthoPilot® Elite and Robotic-assisted MAKO® Total Knee ArthroplastyNCT05980442 · 2024-07-03
RECRUITINGThe Osteoarthritis Prevention StudyNCT05946044 · 2024-03-21
RECRUITINGPartial Synovectomy in Articular Side of Quadriceps Tendon Verified to Reduce Crepitus in Retrospective StudyNCT06129214 · 2023-10-16
RECRUITINGThe ATtune Knee Outcome StudyNCT04247672 · 2020-02-03
RECRUITINGPhysica System Total Knee Replacement Registry StudyNCT03048201 · 2017-03-24
RECRUITINGPre-emptive Insulin to Prevent High Glucose After a Knee Steroid Injection in Adults With Type 2 DiabetesNCT07757464 · 2026-08-10
ACTIVE_NOT_RECRUITINGThe Clinical Impact of Diet on Medical Conditions Treated Within Bundled Payment Models: a Pilot StudyNCT05735873 · 2024-11-01
WITHDRAWNBarriers and Faciliators for Physical Activity in People With RMDsNCT06514443 · 2024-08-01
UNKNOWNA Study of Retatrutide (LY3437943) in Participants Who Have Obesity or OverweightNCT05929066 · 2023-07-10
COMPLETEDA Hip Flexion Feedback System for Exercise Monitoring in Individuals With Osteoarthritis and ObesityNCT05997862 · 2023-07-01
UNKNOWNPersona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)NCT05787821 · 2023-06-28
ACTIVE_NOT_RECRUITINGTotal Joint Arthroplasty (TJA) Weight Loss StudyNCT05156762 · 2022-10-03
TERMINATEDRole of Topical Vancomycin in Reducing Infections in Hip and Knee ArthroplastyNCT05972603 · 2022-07-01
UNKNOWNOA Optimization Program Pilot TrialNCT05389371 · 2022-06-28
UNKNOWNOA Clinic-Community CARE ModelNCT05349500 · 2022-06-07
COMPLETEDAlgarve Active Ageing - Cardiac and Osteoarthritis Rehabilitation (A3-COR)NCT05999110 · 2022-06-01
UNKNOWNImpact of a POPOP on Preoperative Health, Eligibility, and Clinical & Patient-Reported Outcomes in TJANCT04910048 · 2022-01-17
COMPLETEDContinuous Glycemia Monitoring in Perioperative Period in Patients Undergoing Total Knee or Hip ArthroplastyNCT04444570 · 2021-12-01
UNKNOWNA Telehealth Study of a Wearable Electroceutical & Sports Sleeve for Knee Osteoarthritis Pain Relief & Improved FunctionNCT04938271 · 2021-11-22
UNKNOWNPersonalized Exercise Therapy and Self-management Support for Patients With MultimorbidityNCT04645732 · 2021-11-01
COMPLETEDThe POMELO (Prevention Of MusclE Loss in Osteoarthritis) TrialNCT05026385 · 2021-09-20
COMPLETEDEvaluation of Medium Cross-linked Polyethylene With and Without Vitamin E for Total Knee ArthroplastyNCT04618016 · 2021-03-08
ACTIVE_NOT_RECRUITINGEvaluation of The Safety And Performance of The Freedom Total Knee® System With The PEEK-OPTIMA Femoral ComponentNCT03224689 · 2021-01-01
UNKNOWNAssessment of 99mTc-NTP 15-5 Uptake on Cartilage, a New Proteoglycan TracerNCT04481230 · 2020-11-12
COMPLETEDCharacteristics of Marrow Fatty Cells in the Ageing of Bone and Joints, Osteoarthritis and OsteoporosisNCT03678831 · 2020-06-30
COMPLETEDIncreased Blood Glucose Levels After Steroid InjectionNCT06228911 · 2020-01-15
COMPLETEDChronic Pain, Couples, & Physical ActivityNCT04077164 · 2019-04-09
TERMINATEDEffect Of The Use Of Navigation In The Alignment Obtained When Performing A Total Knee Arthroplasty In Obese PatientsNCT03865524 · 2019-02-07
COMPLETEDA Comparison of Two Surgical Techniques Using the Unity Knee™ Total Knee SystemNCT03511144 · 2018-07-01
WITHDRAWNStudy of Hip and Knee Arthroplasty in South AfricaNCT03540667 · 2018-05-07
COMPLETEDEffects of Diet Control and Resistance Exercise Training on Obesity Adults With Knee OsteoarthritisNCT03973463 · 2018-05-03
UNKNOWNEarly Biomarkers for ARthritic PAIN to Guide Improved Treatments for ArthritisNCT03533569 · 2018-04-02
UNKNOWNEffects of a Clinical Dietary Intervention During Inpatient TreatmentNCT03785197 · 2018-02-01
UNKNOWNTransplantation of Autologous Bone Marrow Derived Stem Cells in Patients With Rheumatoid ArthritisNCT03067870 · 2016-11-01
UNKNOWNChanges in Skin Autoflouresence Following Weight Loss and Maintenance Using Liraglutide in Knee OsteoarthritisNCT02910570 · 2016-11-01
COMPLETEDWeight Loss and Physical Activity in Overweight/Obese Individuals With Knee OsteoarthritisNCT02910544 · 2016-11-01
COMPLETEDComparison of Treatments Following Total Knee ReplacementNCT02237911 · 2014-12-01
COMPLETEDStaying Active With Arthritis: RCT of Physical Activity for Older Adults With Osteoarthritis and HypertensionNCT01280903 · 2012-01-01
COMPLETEDWeight Loss Intervention Before Total Knee ReplacementNCT01469403 · 2011-08-01
COMPLETEDVanguard Rocc Post Market SurveillanceNCT03664791 · 2009-10-23
UNKNOWNLong-term Intervention With Weight Loss in Patients With Concomitant Obesity and Knee Osteoarthritis. The LIGHT StudyNCT00938808 · 2009-06-01
COMPLETEDInfluence of Weight Loss or Exercise on Cartilage in Obese Knee Osteoarthritis PatientsNCT00655941 · 2008-04-01
COMPLETEDImproving Motivation for Physical Activity in Arthritis Clinical TrialNCT00248105 · 2005-09-01
COMPLETEDGamma Vacuum Foil (GVF) Versus Cross-linked Polyethylene in Total Knee Arthroplasty StudyNCT00289133 · 2005-02-01
COMPLETEDBalanced Knee System Clinical Protocol for IRB ApprovalNCT02362867 · 2003-01-01
COMPLETEDPrevention of Arthritis-Related Work DisabilityNCT00000416 · 1997-09-01
COMPLETEDCommon interventions
PlaceboDRUG2Total Knee ArthroplastyDEVICE20,35% povidone-iodine solution lavagePROCEDURE11.0 g Vancomycin powder into the woundPROCEDURE18 weeks weight loss program, Cambridge.BEHAVIORAL199mTc-NTP 15-5 at a diagnostic activity of 10 MBq/kgDRUG199mTc-NTP 15-5 at a diagnostic activity of 15 MBq/kgDRUG199mTc-NTP 15-5 at a diagnostic activity of 5 MBq/kgDRUG1Alberta Healthy Living ProgramBEHAVIORAL1Alberta Obesity Centre ProgramBEHAVIORAL1Attention-ControlBEHAVIORAL1Balanced Knee SystemDEVICE1Bariatric surgeryPROCEDURE1Clinic-based outpatient exercise groupOTHER1Community-based exercise groupOTHER1Continuous glycemia measuring device (Dexcom) implantation into the subcutaneous tissueDEVICE1day formula dietDIETARY_SUPPLEMENT1Diet and ExerciseBEHAVIORAL1Dietary instructionBEHAVIORAL1Elastic knee joint movementBEHAVIORAL1ExerciseOTHER1HEAL-122 microcurrent electroceutical with e-textile sports knee sleeveDEVICE1HFFSDEVICE1Insulin Isophane Human, NPH, Pre-emptive AlgorithmDRUG1Intensive dietary interventionDIETARY_SUPPLEMENT1
Leading sponsors
Aesculap AG3Henning Bliddal2Parker Research Institute2University of Pittsburgh2Zimmer Biomet2Anne-Kathrin Rausch1Associação para o Desenvolvimento do Centro Académico de Investigação e Formação Biomédica do Algarv1Boston Medical Center1Boston University Charles River Campus1Centre Jean Perrin1Chang Gung Memorial Hospital1Charite University, Berlin, Germany1Corin1DePuy Orthopaedics1Eli Lilly and Company1
Trial status mix
COMPLETED21
UNKNOWN13
RECRUITING9
ACTIVE_NOT_RECRUITING3
TERMINATED2
WITHDRAWN2
Phase mix
NA26
PHASE14
PHASE23
PHASE43
PHASE32
EARLY_PHASE11
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Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.