Disease & disorder

abdominal aortic aneurysm

MONDO:0005350

Enlargement and ballooning of the vessel that supplies arterial blood to the abdomen, pelvis and legs.

Clinical trials20
Recruiting1
Drug concepts studied2
Synonyms1

Research intelligence

Directly mapped studies only · unique clinical trials

Current registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.

Medications under investigation

Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.

Loading mapped interventions…

MONDO disease family

Loading verified ontology relationships…

Recruiting studies by city

Loading research-site locations…

Trial status

Loading…

Trial phase

Loading…

Study start year

Loading…

Investigated drug interventions

Loading…
Background context

Abdominal aortic aneurysm

Abdominal aortic aneurysm (AAA) is a localized enlargement of the abdominal aorta such that the diameter is greater than 3 cm (1.2 in) or more than 50% larger than normal. An AAA usually causes no symptoms, except during rupture. Occasionally, abdominal, back, or leg pain may occur. Large aneurysms can sometimes be felt by pushing on the abdomen. Rupture may result in pain in the abdomen or back, low blood pressure, or loss of consciousness, and often results in death. AAAs occur most commonly in men, those over 50, and those with a family history of the disease. Additional risk factors include smoking, high blood pressure, and other heart or blood vessel diseases. Genetic conditions with an increased risk include Marfan syndrome and Ehlers–Danlos syndrome. AAAs are the most common form of aortic aneurysm. About 85% occur below the kidneys, with the rest either at the level of or above the kidneys. In the United States, screening with abdominal ultrasound is recommended for males between 65 and 75 years of age with a history of smoking. In the United Kingdom and Sweden, screening all men over 65 is recommended. Once an aneurysm is found, further ultrasounds are typically done regularly because aneurysms grow, and monitoring to identify when an aneurysm meets a threshold for repair Abstinence from cigarette smoking is the single best way to prevent the disease. Other methods of prevention include treating high blood pressure, treating high blood cholesterol, and avoiding being overweight. Surgery is usually recommended when the diameter of an AAA grows to >5.5 cm in males...

Background only. Canonical identity remains MONDO; clinical-trial relationships come from ClinicalTrials.gov.

Clinical trials

20 shown
Epidemiology of Abdominal Aortic Aneurysm With Concomitant Primary Lung CancerNCT06775821 · 2022-10-01
RECRUITING
Pilot Study on the Effectiveness and Safety of OPTILENE® SILVER MESH ELASTIC in Prevention of Surgical Site Infection (SSI) and Incisional Hernia (IH)NCT06547138 · 2026-09-01
NOT_YET_RECRUITING
EQUITA - A Feasibility Trial of a Faith-placed Intervention to Increase Screening Uptake in Black AdultsNCT06981182 · 2025-09-01
NOT_YET_RECRUITING
Evaluation of the Impact of Prehabilitation on Recovery Following Open Surgery for Abdominal Aortic AneurysmNCT05375292 · 2022-12-06
UNKNOWN
Evaluation of Implementation of a National Point-of-Care Ultrasound Training ProgramNCT03296280 · 2016-10-03
COMPLETED
The Intersectional Viborg Screening Program: Cost-(Effectiveness) of Screening for Diabetes and Cardiovascular DiseasesNCT03395509 · 2014-08-01
ENROLLING_BY_INVITATION
Understanding the Role of Autoimmune Disorders on the Initial Presentation of Cardiovascular DiseaseNCT02062021 · 2014-01-01
UNKNOWN
Ethnicity and Onset of Cardiovascular Disease: A CALIBER StudyNCT02176174 · 2013-12-01
COMPLETED
Social Deprivation and Initial Presentation of 12 Cardiovascular Diseases: a CALIBER StudyNCT01937065 · 2012-01-01
UNKNOWN
Heart Rate and Initial Presentation of Cardiovascular Diseases (Caliber)NCT01947361 · 2012-01-01
UNKNOWN
Study on Anti-inflammatory Effect of Anti-hypertensive Treatment in Patients With Small AAA's and Mild HypertensionNCT01425242 · 2011-09-01
TERMINATED
Screening for Abdominal Aortic Aneurysm and Abdominal Aortic Atherosclerosis by Hand-Held UltrasonographyNCT01679288 · 2011-01-01
COMPLETED
Associations Between Diabetes, Arterial Stiffness and Fibulin-1 in Patients Undergoing Heart- and Vascular Surgery?NCT01106573 · 2010-06-01
UNKNOWN
Telesonography Adaptation and Use to Improve the Standard of Patient Care Within a Dominican CommunityNCT00591968 · 2008-01-01
COMPLETED
Body Mass Index and Initial Presentations of Cardiovascular DiseasesNCT01704300 · 2001-01-01
COMPLETED
Serum Uric Acid Levels and Onset of Cardiovascular Diseases: a CALIBER StudyNCT03425305 · 1998-01-01
UNKNOWN
White Blood Cell Counts and Onset of Cardiovascular Diseases: a CALIBER StudyNCT02014610 · 1997-01-01
UNKNOWN
The Role of Alcohol Consumption in the Aetiology of Different Cardiovascular Disease Phenotypes: a CALIBER StudyNCT01864031 · 1997-01-01
UNKNOWN
Risk Factors in the Initial Presentation of Specific Cardiovascular Disease SyndromesNCT01804439 · 1997-01-01
COMPLETED
Honolulu Heart ProgramNCT00005123 · 1965-07-01
COMPLETED

Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.