abducens nerve palsy
MONDO:0007033
Paralysis of the abducens nerve.
Research intelligence
Directly mapped studies only · unique clinical trialsCurrent registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.
Medications under investigation
Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.
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Sixth nerve palsy
Sixth nerve palsy, or abducens nerve palsy, is a disorder associated with dysfunction of cranial nerve VI (the abducens nerve), which is responsible for causing contraction of the lateral rectus muscle to abduct (i.e., turn out) the eye. The inability of an eye to turn outward results in a convergent strabismus or esotropia, of which the primary symptom is diplopia (commonly known as double vision), in which the two images appear side-by-side. Thus, the diplopia is horizontal and worse in the distance. Diplopia is also increased when looking at the affected side. It is partly caused by overaction of the medial rectus on the unaffected side as it tries to provide the extra innervation to the affected lateral rectus. These two muscles are synergists or "yoke muscles" as both attempt to move the eye to the left or right. The condition is commonly unilateral but can also occur bilaterally. The unilateral abducens nerve palsy is the most common isolated ocular motor nerve palsies.
Background only. Canonical identity remains MONDO; clinical-trial relationships come from ClinicalTrials.gov.Drugs being studied
Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.