Disease & disorder

abducens nerve palsy

MONDO:0007033

Paralysis of the abducens nerve.

Clinical trials0
Recruiting0
Drug concepts studied0
Synonyms14

Research intelligence

Directly mapped studies only · unique clinical trials

Current registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.

Medications under investigation

Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.

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Background context

Sixth nerve palsy

Sixth nerve palsy, or abducens nerve palsy, is a disorder associated with dysfunction of cranial nerve VI (the abducens nerve), which is responsible for causing contraction of the lateral rectus muscle to abduct (i.e., turn out) the eye. The inability of an eye to turn outward results in a convergent strabismus or esotropia, of which the primary symptom is diplopia (commonly known as double vision), in which the two images appear side-by-side. Thus, the diplopia is horizontal and worse in the distance. Diplopia is also increased when looking at the affected side. It is partly caused by overaction of the medial rectus on the unaffected side as it tries to provide the extra innervation to the affected lateral rectus. These two muscles are synergists or "yoke muscles" as both attempt to move the eye to the left or right. The condition is commonly unilateral but can also occur bilaterally. The unilateral abducens nerve palsy is the most common isolated ocular motor nerve palsies.

Background only. Canonical identity remains MONDO; clinical-trial relationships come from ClinicalTrials.gov.

Drugs being studied

Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.