adenoid hypertrophy
MONDO:0000740
An upper respiratory tract disease characterized by the unusual growth of the adenoid tonsil; has symptom snoring, has symptom hyponasality, has symptom otitis media with effusion, has symptom mouth breathing.
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Directly mapped studies only · unique clinical trialsCurrent registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.
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Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.
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Adenoid hypertrophy
Adenoid hypertrophy, also known as enlarged adenoids refers to an enlargement of the adenoid (pharyngeal tonsil) that is linked to nasopharyngeal mechanical blockage and/or chronic inflammation. Adenoid hypertrophy is a characterized by hearing loss, recurrent otitis media, mucopurulent rhinorrhea, chronic mouth breathing, nasal airway obstruction, increased infection susceptibility, dental malposition, and dentofacial abnormalities ("adenoid facies" or "mouth breather face"). The exact cause of adenoid hypertrophy in children remains unclear, but it is likely linked to immunological responses, hormonal factors, or genetic components. Adenoid hypertrophy is an immunological abnormality characterized by altered cytokine production, with children experiencing higher levels of proinflammatory cytokines. Adenoid hypertrophy can also be caused by gastric juice exposure during gastroesophageal reflux disease, passive smoking, and recurrent bacterial and viral infections. Pathogen colonization can disrupt the immune system's equilibrium with the adenoid's natural flora. Genetic factors, such as variations in TLR2 and TLR4 genes, also contribute to the condition. Adenoids naturally undergo hypertrophy between the ages of 6-10 and atrophy around 16 years old. A clinical examination and nasoendoscopy are the gold standard for diagnosing adenoid hypertrophy. Visual examinations should be conducted to identify adenoid facies, eczema, and similar signs in diseases like partial choanal atresia, significant palatine tonsil hyperplasia, nasal airway blockage, endonasal foreign bodies, n...
Background only. Canonical identity remains MONDO; clinical-trial relationships come from ClinicalTrials.gov.Drugs being studied
Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.