African swine fever
MONDO:0025377
A sometimes fatal asfivirus infection of pigs, characterized by fever, cough, diarrhea, hemorrhagic lymph nodes, and edema of the gallbladder. It is transmitted between domestic swine by direct contact, ingestion of infected meat, or fomites, or mechanically by biting flies or soft ticks (genus Ornithodoros).
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Directly mapped studies only · unique clinical trialsCurrent registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.
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Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.
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African swine fever virus
African swine fever virus (ASFV) is a large, double-stranded DNA virus in the Asfarviridae family, and the causative virus of African swine fever (ASF). The virus causes a hemorrhagic fever with high mortality rates in domestic pigs, with some isolates capable of causing death of affected animals as quickly as within a week of being infected. ASFV persistently infects its natural hosts, includingwarthogs, bushpigs, and soft ticks of the genus Ornithodoros, which likely act as a vector with no outward signs of disease. ASFV does not cause disease in humans. ASFV is endemic to sub-Saharan Africa and exists in the wild through a cycle of infection between ticks and wild pigs, bushpigs, humans and warthogs. The disease was first described after European settlers brought pigs into areas endemic with ASFV, and as such, is an example of an emerging infectious disease. ASFV replicates in the cytoplasm of infected cells. African Swine Fever Virus is the only virus with a double-stranded DNA genome known to be transmitted by arthropods.
Background only. Canonical identity remains MONDO; clinical-trial relationships come from ClinicalTrials.gov.Drugs being studied
Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.