Disease & disorder

Alice in Wonderland syndrome

MONDO:0024429

A disorienting neuropsychological condition that affects perception. People experience size distortion such as micropsia, macropsia, pelopsia, or teleopsia. Size distortion may occur of other sensory modalities.

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Research intelligence

Directly mapped studies only · unique clinical trials

Current registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.

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Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.

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Background context

Alice in Wonderland syndrome

Alice in Wonderland syndrome (AIWS), also known as Todd's syndrome or dysmetropsia, is a neurological disorder that distorts perception. People with this syndrome may experience distortions in their visual perception of objects, such as appearing smaller (micropsia) or larger (macropsia), or appearing to be closer (pelopsia) or farther (teleopsia) than they are. Distortion may also occur for senses other than vision. The cause of Alice in Wonderland syndrome is unknown, but it is often associated with migraines, head trauma, or viral encephalitis caused by Epstein–Barr Virus Infection. It is also theorized that AIWS can be caused by abnormal cerebral electrical activity, resulting in abnormal blood flow in the parts of the brain that process visual perception and texture. Alice in Wonderland syndrome is also possible to be experienced temporarily under the use of certain psychoactive drugs. Although Alice in Wonderland syndrome can occur in both adolescents and adults, it is more commonly seen in children.

Background only. Canonical identity remains MONDO; clinical-trial relationships come from ClinicalTrials.gov.

Drugs being studied

Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.