arteriosclerosis disorder
MONDO:0002277
A vascular disorder characterized by thickening and hardening of the walls of the arteries.
Research intelligence
Directly mapped studies only · unique clinical trialsCurrent registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.
Medications under investigation
Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.
MONDO disease family
Recruiting studies by city
Trial status
Trial phase
Study start year
Investigated drug interventions
Arteriosclerosis
Arteriosclerosis, literally meaning "hardening of the arteries", is an umbrella term for a set of vascular disorders characterized by abnormal thickening, hardening, and loss of elasticity in the walls of arteries. The disease process gradually restricts blood flow to body organs and tissues and can proceed to severe health risks brought on by atherosclerosis, which is the specific form of arteriosclerosis caused by buildup of fatty plaques, cholesterol, and other substances in and on arterial walls. Risk factors include family history, smoking, and obesity. Atherosclerosis is the primary cause of coronary artery disease (CAD) and stroke, with multiple genetic and environmental contributions. Genetic-epidemiologic studies have identified many genetic and non-genetic risk factors for CAD. However, such studies indicate that family history is the most significant independent risk factor.
Background only. Canonical identity remains MONDO; clinical-trial relationships come from ClinicalTrials.gov.Drugs being studied
Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.