chronic obstructive pulmonary disease
MONDO:0005002
A chronic and progressive lung disorder characterized by the loss of elasticity of the bronchial tree and the air sacs, destruction of the air sacs wall, thickening of the bronchial wall, and mucous accumulation in the bronchial tree. The pathologic changes result in the disruption of the air flow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough, and chest tightness. The two main types of chronic obstructive pulmonary disease are chronic obstructive bronchitis and emphysema.
Research intelligence
Directly mapped studies only · unique clinical trialsCurrent registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.
Medications under investigation
Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.
MONDO disease family
Recruiting studies by city
Trial status
Trial phase
Study start year
Investigated drug interventions
Chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) is a long-term lung condition that makes it progressively harder to breathe. It occurs when the airways and lung tissue become damaged, leading to reduced airflow and reduced efficiency of oxygen exchange in the lungs. COPD develops gradually over time, and while it cannot currently be cured, treatments and lifestyle changes can help control symptoms and slow disease progression. Early diagnosis and prompt treatment are recommended. The condition includes two related lung problems: chronic bronchitis and emphysema. Chronic bronchitis involves ongoing inflammation of the airways, causing excess mucus production, coughing, and chest discomfort. Emphysema involves damage to the small air sacs in the lungs, which reduces the lungs' ability to transfer oxygen into the bloodstream. Many people with COPD experience shortness of breath, persistent cough, wheezing, and reduced exercise tolerance. Symptoms can become more severe during acute flare-ups, which can be triggered by viral and bacterial infections and exposure to irritants. People with COPD generally display a combination of these symptoms, and are likely to have additional health issues. COPD can develop due to multiple factors, most often involving long-term exposure to lung irritants. The strongest risk factors are tobacco smoke, air pollution, and workplace dust and chemical fumes. Smoke from fuels used for cooking and heating is a primary risk factor in some places, particularly for women and young children. Factors affecting lung development in early life such as respir...
Background only. Canonical identity remains MONDO; clinical-trial relationships come from ClinicalTrials.gov.Clinical trials
40 shownDrugs being studied
Research locations
Leading sponsors
Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.