Disease & disorder

chronic obstructive pulmonary disease

MONDO:0005002

A chronic and progressive lung disorder characterized by the loss of elasticity of the bronchial tree and the air sacs, destruction of the air sacs wall, thickening of the bronchial wall, and mucous accumulation in the bronchial tree. The pathologic changes result in the disruption of the air flow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough, and chest tightness. The two main types of chronic obstructive pulmonary disease are chronic obstructive bronchitis and emphysema.

Clinical trials3,823
Recruiting290
Drug concepts studied20
Synonyms12

Research intelligence

Directly mapped studies only · unique clinical trials

Current registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.

Medications under investigation

Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.

Loading mapped interventions…

MONDO disease family

Loading verified ontology relationships…

Recruiting studies by city

Loading research-site locations…

Trial status

Loading…

Trial phase

Loading…

Study start year

Loading…

Investigated drug interventions

Loading…
Background context

Chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a long-term lung condition that makes it progressively harder to breathe. It occurs when the airways and lung tissue become damaged, leading to reduced airflow and reduced efficiency of oxygen exchange in the lungs. COPD develops gradually over time, and while it cannot currently be cured, treatments and lifestyle changes can help control symptoms and slow disease progression. Early diagnosis and prompt treatment are recommended. The condition includes two related lung problems: chronic bronchitis and emphysema. Chronic bronchitis involves ongoing inflammation of the airways, causing excess mucus production, coughing, and chest discomfort. Emphysema involves damage to the small air sacs in the lungs, which reduces the lungs' ability to transfer oxygen into the bloodstream. Many people with COPD experience shortness of breath, persistent cough, wheezing, and reduced exercise tolerance. Symptoms can become more severe during acute flare-ups, which can be triggered by viral and bacterial infections and exposure to irritants. People with COPD generally display a combination of these symptoms, and are likely to have additional health issues. COPD can develop due to multiple factors, most often involving long-term exposure to lung irritants. The strongest risk factors are tobacco smoke, air pollution, and workplace dust and chemical fumes. Smoke from fuels used for cooking and heating is a primary risk factor in some places, particularly for women and young children. Factors affecting lung development in early life such as respir...

Background only. Canonical identity remains MONDO; clinical-trial relationships come from ClinicalTrials.gov.

Clinical trials

40 shown
Effects of TPB-Based Cadence Exercise and Breathing Training on Physiological Parameters and Quality of Life in Patients With COPDNCT07860008 · 2026-10-06
RECRUITING
Comparison of Arterial and Capillary Blood Gas Analyses in Patients With Respiratory Distress Due to COPD or APENCT07835945 · 2026-09-28
RECRUITING
BREZTRI REGULATORY POST MARKETING SURVEILLANCE IN KOREANCT07570394 · 2026-09-17
RECRUITING
A Study to Evaluate the Long-term Safety and Efficacy of Lunsekimig in Adult Participants With Chronic Obstructive Pulmonary Disease (COPD)NCT07793409 · 2026-09-16
RECRUITING
Cognitive Load and Inhaler Technique in COPDNCT07786220 · 2026-08-21
RECRUITING
Effect of Exercise Order During Pulmonary Rehabilitation on Muscle Strength in Patients With COPDNCT07655011 · 2026-08-06
RECRUITING
A Study of the Safety, Tolerability, Pharmacokinetics and Efficacy of KIT2014 in Patients With Moderate to Severe COPDNCT07668518 · 2026-08-05
RECRUITING
Dynamic Functional Imaging Phenotyping and Disease Progression Risk Assessment in COPD Using Dynamic Chest Radiography: A Multicenter Retrospective StudyNCT07762573 · 2026-08-03
RECRUITING
Effect of Individualized Positive End-expiratory Pressure (PEEP) in Patients Who Have an Intrinsic PEEP During One-lung VentilationNCT07638176 · 2026-08-01
RECRUITING
T2AIR: Real-World Efficacy and Safety of Biologics Targeting Type 2 Inflammation in Asthma and COPDNCT07823842 · 2026-07-30
RECRUITING
A Clinical Trial to Evaluate the Efficacy and Safety of HRS-9821 Inhalation Suspension in Patients With Moderate to Severe Chronic Obstructive Pulmonary DiseaseNCT07640451 · 2026-07-20
RECRUITING
PEP Buddy in Pulmonary RehabilitationNCT07404826 · 2026-07-16
RECRUITING
Nebulizer Versus Handheld Maintenance Therapy for Patients With COPDNCT07816835 · 2026-07-14
RECRUITING
A Phase I Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of HRS-9821 Powder for Inhalation Administered as a Single Dose in Healthy Participants and Multiple Doses in Patients With COPDNCT07567872 · 2026-07-09
RECRUITING
COPD Flare-Up Clinic After Severe ExacerbationsNCT07629869 · 2026-07-01
RECRUITING
To Evaluate the Effect of EXPD-101/FXS7553 Compared With Placebo in Patients With COPD Over 52 Weeks of TreatmentNCT07684820 · 2026-06-30
RECRUITING
Expression of SLC25A48 in Chronic Obstructive Pulmonary DiseaseNCT07474220 · 2026-06-29
RECRUITING
Comparing Ultrasonic and Conventional Spirometry in Chronic Respiratory DiseaseNCT07447232 · 2026-06-29
RECRUITING
Effects of Blood Flow Restriction Rehabilitation on Functional Mobility and Balance Among Chronic Obstructive Pulmonary Disease Patients.NCT07805330 · 2026-06-24
RECRUITING
SPARK: Supporting Physical Activity Through Reality-Augmented Knowledge in COPDNCT07837375 · 2026-06-15
RECRUITING
Continuous Versus High Intensity Interval Exercise in Chronic Obstructive Pulmonary DiseaseNCT07707271 · 2026-06-15
RECRUITING
Effects of Laura Mitchell's and Benson Relaxation Technique On Anxiety, Sleep Quality and Fatigue Among COPD PatientsNCT07635446 · 2026-06-01
RECRUITING
Measurements Before and After Participation in a Health Intervention Programme in Halsnaes MunicipalityNCT07641309 · 2026-05-28
RECRUITING
Long-term Safety and Tolerability of Tozorakimab in Patients With COPD and History of ExacerbationsNCT07566195 · 2026-05-05
RECRUITING
Effect of Simeox® on Residual Volume in COPD Patients With Pulmonary HyperinflationNCT07665931 · 2026-05-05
RECRUITING
Improving Patient-Centered Care for Underserved Older African American Patients With Cardiovascular ComorbiditiesNCT07748858 · 2026-05-01
RECRUITING
Prospective Dynamic Cohort Study of Phenotypic Profiles in Patients With Chronic Obstructive Pulmonary DiseaseNCT07627763 · 2026-05-01
RECRUITING
Feasibility Study of a Digital Interactive Life-style Platform for Individuals After RehabilitationNCT07597031 · 2026-05-01
RECRUITING
CLEAR Model for Predicting Ventilatory Liberation in Severe COPDNCT07579052 · 2026-04-29
RECRUITING
129-Xe MRI Study of Single Triple Therapy Inhaler Effects in COPD Patients With Moderate-severe Dyspnea and/or Poor Health Status With High or Low Risk of ExacerbationNCT07192016 · 2026-04-24
RECRUITING
Identification of Diagnostic and Prognostic Biomarkers in the Pathological Continuum of Bronco Chronic Obstructive Pulmonary Disease, Idiopathic Pulmonary Fibrosis and Pulmonary NeoplasiaNCT07707245 · 2026-04-22
RECRUITING
D-RSBI Versus RSBI for Predicting Weaning Success in COPD PatientsNCT07590362 · 2026-04-15
RECRUITING
Evaluation of the Inhaled TQC3721 Suspension in Patients With Moderate-to-Severe Chronic Obstructive Pulmonary DiseaseNCT07464587 · 2026-04-14
RECRUITING
Turkish Validation of the Nijmegen Questionnaire in COPDNCT07344649 · 2026-04-13
RECRUITING
Effects of Oxygen Supplementation During the 6-Minute Walk Test in Chronic Respiratory Failure or Exertional HypoxemiaNCT07451977 · 2026-04-02
RECRUITING
Inclined Versus Standard Exercise for COPD PatientsNCT06749262 · 2026-04-01
RECRUITING
Hypnosis on Breathlessness Mastery in Patients With Persistent DyspneaNCT07173348 · 2026-04-01
RECRUITING
A Multi Center Study Testing a New Implant for Adults With Severe EmphysemaNCT07119229 · 2026-03-25
RECRUITING
Treatment of Chronic Obstructive Pulmonary Disease (COPD) by REGEND007 Cell TherapyNCT07355868 · 2026-03-19
RECRUITING
Different Inspiratory Muscle Trainings in Patients With COPDNCT07406659 · 2026-03-11
RECRUITING

Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.