chronic wasting disease

Chronic wasting disease

Chronic wasting disease (CWD), is a transmissible spongiform encephalopathy (TSE) naturally affecting members of the deer family. TSEs are a family of diseases caused by misfolded proteins called prions and include similar diseases such as mad cow disease in cattle, Creutzfeldt–Jakob disease in humans, and scrapie in sheep. In the United States, CWD affects mule deer, white-tailed deer, red deer, sika deer, elk, caribou, and moose. The transmission of CWD to other species such as squirrel monkeys and humanized mice has been observed in experimental settings. In 1967, CWD was first identified in mule deer at a government research facility in northern Colorado, United States. It was initially recognized as a clinical "wasting" syndrome and then in 1978, it was identified more specifically as a TSE disease. Since then, CWD has been found in free-ranging and captive animal populations in 33 US states and five Canadian provinces. In addition, CWD has been found in one Minnesota red deer farm, one wild reindeer herd in Norway (March 2016) as well as in wild moose. Single cases of CWD in moose have been found in Finland (March 2018) and in Sweden (March and May 2019, September 2020). CWD was found in South Korea in some deer imported from Canada. CWD is typified by chronic weight loss and clinical signs compatible with brain lesions, aggravated over time, always leading to death. Although reports in the popular press have been made of humans being affected by CWD, a 2004 study for the US Centers for Disease Control and Prevention concluded that "more epidemiologic and laborator...