Disease & disorder

cytomegalovirus retinitis

MONDO:0000878

Infection of the retina by cytomegalovirus characterized by retinal necrosis, hemorrhage, vessel sheathing, and retinal edema. Cytomegalovirus retinitis is a major opportunistic infection in aids patients and can cause blindness.

Clinical trials60
Recruiting0
Drug concepts studied12
Synonyms4

Research intelligence

Directly mapped studies only · unique clinical trials

Current registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.

Medications under investigation

Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.

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Background context

Cytomegalovirus retinitis

Cytomegalovirus retinitis, also known as CMV retinitis, is an inflammation of the retina of the eye that can lead to blindness. Caused by human cytomegalovirus, it occurs predominantly in people whose immune system has been compromised, including 15-40% of those with AIDS.

Read on Wikipedia ↗ Wikidata Q4271835 ↗
Background only. Canonical identity remains MONDO; clinical-trial relationships come from ClinicalTrials.gov.

Clinical trials

40 shown
Deep Learning-based System and AIDS-related Cytomegalovirus RetinitisNCT04831333 · 2021-04-01
COMPLETED
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of CareNCT01431326 · 2011-11-01
COMPLETED
Efficacy of Elevated CD4 Counts on CMV RetinitisNCT00091884 · 2004-07-01
COMPLETED
Longitudinal Study of Ocular Complications of AIDS (LSOCA)NCT00000168 · 1998-08-01
COMPLETED
Studies of Ocular Complications of AIDS (SOCA)--Ganciclovir-Cidofovir CMV Retinitis Trial (GCCRT)NCT00000143 · 1997-05-01
COMPLETED
Immune Activity Against CVM RetinitisNCT00001611 · 1997-02-01
COMPLETED
A Comparison of Valganciclovir and Ganciclovir in the Treatment of Cytomegalovirus (CMV) of the EyesNCT00002377 · 1997-01-01
COMPLETED
Studies of the Ocular Complications of AIDS (SOCA)--Monoclonal Antibody CMV Retinitis Trial (MACRT)NCT00000135 · 1995-09-01
COMPLETED
Phase II Randomized Study of Cidofovir for Peripheral Cytomegalovirus RetinitisNCT00004794 · 1995-03-01
COMPLETED
Studies of the Ocular Complications of AIDS (SOCA)--Cytomegalovirus Retinitis Retreatment Trial (CRRT)NCT00000134 · 1992-12-01
COMPLETED
Ganciclovir Implant Study for Cytomegalovirus RetinitisNCT00000118 · 1992-10-01
COMPLETED
Studies of the Ocular Complications of AIDS (SOCA)--Foscarnet-Ganciclovir CMV Retinitis Trial (FGCRT)NCT00000136 · 1990-03-01
COMPLETED
A Randomized Controlled Study of the Efficacy and Safety of Maintenance Treatment With Oral Ganciclovir for Newly Diagnosed Cytomegalovirus Retinitis in People With AIDSNCT00002257
COMPLETED
A Study of Foscarnet in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS Who Have Not Had Success With GanciclovirNCT00002301
UNKNOWN
Valganciclovir in Patients With CMV Retinitis and AIDS Who Cannot Take Drugs by InjectionNCT00017784
UNKNOWN
An Open Study of Foscarnet Treatment First Episode CMV-Retinitis in AIDS PatientsNCT00002039
COMPLETED
The Safety and Effectiveness of ISIS 2922 in Patients With AIDS Who Have Cytomegalovirus (CMV) of the EyesNCT00002356
COMPLETED
A Study of Valganciclovir in the Treatment of Cytomegalovirus (CMV) Retinitis in Patients With AIDSNCT00002222
COMPLETED
A Study of Viracept in AIDS Patients With Cytomegalovirus RetinitisNCT00002169
COMPLETED
A Phase I/II Trial to Assess the Safety and Tolerance of Escalating Doses of a Human Anti-Cytomegalovirus Monoclonal Antibody (SDZ MSL-109) in Patients With the Acquired Immunodeficiency Syndrome and CMV RetinitisNCT00002016
COMPLETED
A Comparison of ISIS 2922 Used Immediately or Later in Patients With Cytomegalovirus (CMV) of the EyesNCT00002355
COMPLETED
A Study of ISIS 2922 in the Treatment of Advanced Cytomegalovirus RetinitisNCT00002187
COMPLETED
A Randomized Comparison of Intravitreal ISIS 2922 Plus Ganciclovir Versus Ganciclovir as Treatment for Patients With Cytomegalovirus Retinitis ( CMVR )NCT00002156
COMPLETED
A Pilot Study to Obtain Preliminary Information Regarding the Efficacy and Safety of the Combination of Immune Globulin and Ganciclovir as Compared to Ganciclovir Alone in the Treatment of Sight-Threatening CMV Retinitis in Patients With AIDSNCT00001999
COMPLETED
A Study of Foscarnet in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDSNCT00002432
COMPLETED
An Open-Label Safety Study of Oral Ganciclovir Maintenance Treatment of CMV Retinitis in People With Limited Venous AccessNCT00002135
COMPLETED
A Phase I Study of the Safety of Proleukin (Aldesleukin) in Combination With Ganciclovir and Antiretroviral Therapy in HIV Seropositive Patients With Cytomegalovirus (CMV) RetinitisNCT00002321
COMPLETED
Open Label Ganciclovir Therapy for Sight- or Life-Threatening Cytomegalovirus Disease in the Immunocompromised PatientNCT00002025
COMPLETED
An Open-Label Study of the Safety and Efficacy of Cidofovir for the Treatment of Relapsing Cytomegalovirus Retinitis in Patients With AIDSNCT00002142
COMPLETED
A Study of the Safety and Tolerance of Long-Term Therapy With Intravenous Cytovene (Ganciclovir Sodium) for Cytomegalovirus Retinitis in Persons With AIDSNCT00002034
COMPLETED
A Study of Two Forms of Ganciclovir in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDSNCT00002330
COMPLETED
A Multicenter Study of Oral Versus Intravenous Hydration in AIDS Patients With CMV Retinitis Treated With Foscavir (Foscarnet Sodium)NCT00002125
COMPLETED
An Open Label Evaluation of the Safety and Pharmacokinetics of Ganciclovir in ChildrenNCT00002015
COMPLETED
The Safety and Effectiveness of Ganciclovir Plus Interferon Beta in Preventing the Return of Cytomegalovirus (CMV) of the Eyes in Patients With AIDSNCT00002299
COMPLETED
A Study of Cidofovir in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDSNCT00002384
UNKNOWN
HPMPC (Cidofovir) Peripheral CMV Retinitis Trial ProtocolNCT00000799
COMPLETED
A Study of Foscarnet Plus Ganciclovir in the Treatment of Cytomegalovirus of the Eye in Patients With AIDS Who Have Already Been Treated With GanciclovirNCT00000970
COMPLETED
A Study of Ganciclovir in the Treatment of Cytomegalovirus of the EyesNCT00001062
COMPLETED
The Safety and Effectiveness of Ganciclovir Used Alone or in Combination With Granulocyte-Macrophage Colony Stimulating Factor in the Treatment of Cytomegalovirus (CMV) of the Eye in Patients With AIDSNCT00000989
COMPLETED
A Study of Foscarnet in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS Who Cannot Use GanciclovirNCT00000697
WITHDRAWN

Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.