Disease & disorder

dental caries

MONDO:0005276

The decay of a tooth, in which it becomes softened, discolored, and/or porous.

Clinical trials21
Recruiting2
Drug concepts studied0
Synonyms0

Research intelligence

Directly mapped studies only · unique clinical trials

Current registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.

Medications under investigation

Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.

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Background context

Tooth decay

Tooth decay, also known as caries (lit. 'rottenness', from Latin), is the breakdown of teeth due to acids produced by bacteria. The resulting dental cavities may be many different colors, from yellow to black. Symptoms may include pain and difficulty eating. Complications may include periodontal disease (i.e., inflammation of the tissue around the tooth), tooth loss, infection, or dental abscess formation. Tooth regeneration is a field of ongoing stem cell-based study that aims to find methods to reverse the effects of decay; current treatments are limited to symptom management. The cause of cavities is acid from bacteria dissolving the hard tissues of the teeth (enamel, dentin, and cementum). The acid is produced by the bacteria when they break down food debris or sugar on the tooth surface. Simple sugars in food are these bacteria's primary energy source, and thus a diet high in simple sugar is a risk factor. If tooth demineralization is greater than tooth remineralization from sources such as saliva, caries results. Risk factors include conditions that result in less saliva, such as diabetes mellitus, Sjögren syndrome, and some medications, including psychostimulants, antihistamines, and antidepressants. Dental caries is also associated with poverty, poor oral hygiene, and receding gums, resulting in gingival recession (i.e., exposure of the roots of the teeth). Prevention of dental caries includes regular teeth cleanings, a low-sugar diet, and small amounts of regular fluoride exposure. Brushing one's teeth twice daily and flossing between the teeth once daily is rec...

Background only. Canonical identity remains MONDO; clinical-trial relationships come from ClinicalTrials.gov.

Clinical trials

21 shown
Mothers' Action Project for Child HealthNCT06753669 · 2026-02-01
RECRUITING
Advancing Water Security: A Community Participatory School-Based Hydration InterventionNCT06714929 · 2024-08-14
RECRUITING
Obesity and Oral Diseases in Adult PatientsNCT04602572 · 2026-11-01
NOT_YET_RECRUITING
Effects of GLP-1 Receptor Agonists on Saliva and Oral HealthNCT07818226 · 2026-10-16
NOT_YET_RECRUITING
Coronal and Radicular Caries Prevalence and Related Risk Factor in Diabetic PatientNCT06701565 · 2024-12-15
NOT_YET_RECRUITING
An Educational Intervention Program to Improve the Oral Health of HIV-Positive Children in Kano, Nigeria.NCT05540171 · 2022-12-22
COMPLETED
Biomimetic Hydroxyapatite in Pediatric Patients With Asthma and/or Allergic RhinitisNCT05631197 · 2022-03-02
COMPLETED
Are Diabetics Type 2 More Prone to Dental Caries?NCT04883086 · 2020-12-15
COMPLETED
Oral Findings in Pediatric Patients With Allergic Rhinitis and/or AsthmaNCT05576142 · 2019-09-01
COMPLETED
The Influence of Simple, Low-Cost Chemistry Intervention Videos: A Randomized Trial of Children's Preferences for Sugar-Sweetened BeveragesNCT04971317 · 2018-09-05
COMPLETED
Dental and Periodontal Health in Obese Adolescents: Clinical, Biochemical, and Microbiological EvaluationNCT07086027 · 2017-06-10
COMPLETED
Preventing Early Childhood Obesity, Part 1: Family Spirit Nurture, 3-9 MonthsNCT03101943 · 2017-03-29
COMPLETED
TEACH: Technology Evaluation to Address Child HealthNCT02912000 · 2016-09-01
COMPLETED
Comparison of Topical Analgesic With Saline Rinses in Post Extraction HealingNCT02921165 · 2016-05-01
COMPLETED
Associations Between Obesity, Dental Caries, Erosive Tooth Wear and Periodontal Disease in Adolescents: A Case Control-studyNCT05146557 · 2015-07-01
COMPLETED
Primary Care Beverage StudyNCT02257203 · 2014-10-01
COMPLETED
Nutrition Knowledge for Spanish-speaking ParentsNCT01296945 · 2011-02-01
COMPLETED
Herbal Lollipops on Oral Bacterial Levels and DMFT/Dmft Scores of Children With Asthma Using InhalersNCT01147835 · 2009-09-23
TERMINATED
Periodontal and Periapical Inflammation and PregnancyNCT00490165 · 2007-03-01
COMPLETED
Salivary Proteins in Disease and HealthNCT00100204 · 2004-12-21
COMPLETED
Probiotics in Prevention of Allergies, Obesity and CariesNCT00894816 · 2000-08-01
COMPLETED

Drugs being studied

Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.