encephalitozoonosis
MONDO:0005743
Infection with fungi of the genus encephalitozoon. Lesions commonly occur in the brain and kidney tubules. Other sites of infection in mammals are the liver; adrenal glands; optic nerves; retina; and myocardium.
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Directly mapped studies only · unique clinical trialsCurrent registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.
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Encephalitozoonosis
Encephalitozoonosis is a parasitic disease caused by the microsporidia Encephalitozoon cuniculi, which mainly affects rabbits in Europe. Other strains of the pathogen cause disease in Old World mice and canines. Encephalitozoonosis occurs mainly in immunocompromised animals and is a potential zoonosis. Although very rare, it can also occur in immunocompromised humans. Wright and Craighead first described the disease in 1922. The pathogen primarily affects the kidneys and brain, causing neurological disorders. The most common symptom is a tilted head. Fenbendazole, an antiparasitic drug, can be used to combat the pathogen and prevent new infections. If clinical symptoms occur, treatment must be extended by administering antibiotics and supportive measures. The prospects of recovery are uncertain.
Background only. Canonical identity remains MONDO; clinical-trial relationships come from ClinicalTrials.gov.Drugs being studied
Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.