eosinophilic cryptitis
MONDO:0023073
Eosinophilic cystitis (EC) is a rare inflammatory bladder condition caused by the build up of eosinophils in the bladder. The exact cause of this condition is not known. However, EC has been found in those with allergies and asthma, and in those with a history of bladder trauma or infection, open bladder surgery, or surgery for a bladder tumor. EC has also been found in those who take certain medications.
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Eosinophilic cystitis
Eosinophilic cystitis is a rare type of interstitial cystitis first reported in 1960 by Edwin Brown. Eosinophilic cystitis has been linked to a number of etiological factors, including allergies, bladder tumors, trauma to the bladder, parasitic infections, and chemotherapy drugs, though the exact cause of the condition is still unknown. The antigen-antibody response is most likely the cause of eosinophilic cystitis. This results in the generation of different immunoglobulins, which activate eosinophils and start the inflammatory process. The most typical symptom complex includes dysuria, hematuria, frequency, and suprapubic pain. For diagnosis, cystoscopy and biopsy are considered the gold standard. Peripheral eosinophilia, which is rare in patients, microscopic hematuria, proteinuria, and other laboratory findings corroborate the diagnosis. Treatment for eosinophilic cystitis is still up for debate. Antihistamines, antispasmodics, leukotriene antagonists, immunosuppressives, oral and intravesical corticosteroids, and in extreme situations, surgery have all been used in the treatment of symptoms.
Background only. Canonical identity remains MONDO; clinical-trial relationships come from ClinicalTrials.gov.Drugs being studied
Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.