Disease & disorder

frozen shoulder

MONDO:0006763

A painful inflammatory process leads to a mechanical block in active and passive range of motion (ROM) of the shoulder. Adhesive capsulitis of the shoulder is characterized by functional loss of passive and active shoulder motion. This inflammatory process results in fibroblastic proliferation and extensive scar tissue formation. Fibroblastic proliferation, a late phase of the inflammatory process involved in tissue repair, leads to thickening, fibrosis, and adhesion of the capsule to itself and the humerus.

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Directly mapped studies only · unique clinical trials

Current registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.

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Background context

Adhesive capsulitis of the shoulder

Adhesive capsulitis, also known as "frozen shoulder," is a condition characterized by shoulder pain and stiffness. Onset is gradual over weeks to months. A common shoulder ailment, adhesive capsulitis is marked by pain at rest but especially upon movement, as well as a decrease in passive range of motion (particularly in external rotation). The shoulder often does not hurt when touched (non-tender). The exact cause in most cases is unknown. Post-traumatic stiffness after injury or surgery to the shoulder is best considered separately from adhesive capsulitis, which is idiopathic, meaning there are no known causes. The underlying mechanism is believed to involve inflammation and scarring within the shoulder joint capsule, but the cause is unknown. Diagnosis is generally based on a person's symptoms and a physical exam. A key feature that can distinguish adhesive capsulitis from similar conditions is the inability of others to move the shoulder, in addition to the loss of voluntary movement (a loss of both active and passive ranges of motion). This is in contrast to most muscle, tendon, and nerve disorders, where only the active range of motion is limited. Radiographs can exclude glenohumeral arthritis as the source of the loss of passive motion. Imaging is otherwise not used for diagnosis or evaluation. The role of MRI or ultrasound is debatable. The condition can sometimes resolve itself over time without intervention, but this may take several years, and results are better when it is treated. There are a number of non-procedural treatments, including nonsteroidal anti-i...

Background only. Canonical identity remains MONDO; clinical-trial relationships come from ClinicalTrials.gov.

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Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.