Disease & disorder

obsolete childhood disintegrative disease

MONDO:0001726

Clinical trials0
Recruiting0
Drug concepts studied0
Synonyms0

Disease research snapshot

No clinical trials have been linked to this exact normalized concept in the current published dataset. This is a coverage limitation, not evidence that the condition or medicine has never been studied. Try a synonym or browse registry-reported labels.

Numbers are derived from CureCurrent's current ClinicalTrials.gov projection and conservative MONDO/RxNorm mappings. See sources, counting rules and limitations and verify eligibility or clinical findings with the original study record.

Research intelligence

Directly mapped studies only · unique clinical trials

Current registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.

Medications under investigation

Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.

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Background context

Childhood disintegrative disorder

Childhood disintegrative disorder (CDD), also known as Heller syndrome and disintegrative psychosis, is a rare condition characterized by a late onset of developmental delays—or severe and sudden reversals—in language (receptive and expressive), social engagement, bowel and bladder, play and motor skills. Researchers have not been successful in finding a cause for this disorder. CDD has some similarities to autism and is sometimes considered a low-functioning form of it. In May 2013, CDD was one of several subtypes of pervasive developmental disorder (PDD)—including Asperger's syndrome, classic autism, and pervasive developmental disorder not otherwise specified—that was subsumed into a single diagnostic term called "autism spectrum disorder" in the DSM-5 manual. CDD was originally described by Austrian educator Theodor Heller (1869–1938) in 1908, 35 years before Leo Kanner and Hans Asperger described autism. Heller had previously used the name dementia infantilis for this disorder. An apparent period of fairly normal development is often noted before regressions in skills occurs. The age at which this regression can occur varies, but regression after three years of normal development is typical. The regression, known as a prodrome, can be so dramatic that the child may be aware of it, and may in its beginning even ask, vocally, what is happening to them. Some children describe or appear to be reacting to hallucinations, but the most obvious symptom is that skills apparently attained are lost. Many children are already somewhat delayed when the disorder becomes apparent,...

Background only. Canonical identity remains MONDO; clinical-trial relationships come from ClinicalTrials.gov.

Drugs being studied

Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.