Disease & disorder

orthostatic intolerance

MONDO:0001315

A chronic disorder of dysautonomia, characterized by palpitation, shortness of breath, labored breathing, and subjective complaints of effort and discomfort provoked by physical exertion or upright posture, often accompanied by dizziness, tremulousness, sweating, and insomnia. The heart rate increases by at least 30 beats per minute when moving from a recumbent to a standing position (or ≥40 bpm in individuals 12-19 years of age), without orthostatic hypotension. Historically described as soldier's heart, irritable heart, effort syndrome, or Da Costa syndrome. Anxiety is a frequently associated feature rather than the underlying cause.

Clinical trials0
Recruiting0
Drug concepts studied0
Synonyms7

Research intelligence

Directly mapped studies only · unique clinical trials

Current registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.

Medications under investigation

Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.

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Drugs being studied

Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.