pain agnosia
MONDO:0000675
Loss of the ability to perceive and process pain.
Research intelligence
Directly mapped studies only · unique clinical trialsCurrent registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.
Medications under investigation
Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.
MONDO disease family
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Study start year
Investigated drug interventions
Pain asymbolia
Pain asymbolia, also called pain dissociation, is a condition in which pain is experienced without unpleasantness. This usually results from injury to the brain, lobotomy, cingulotomy, or morphine analgesia. Preexisting lesions of the insula may abolish the aversive quality of painful stimuli while preserving the location and intensity aspects. Typically, patients report they have pain but are not bothered by it; they recognize the sensation of pain but are mostly or completely immune to suffering from it. The pathophysiology of this disease revolves around a disconnect between the insular cortex secondary to damage and the limbic system, specifically the cingulate gyrus, whose prime response to the pain perceived by the insular cortex is to tether it with an agonizing emotional response, thus signaling the individual of its propensity to inflict actual harm. However, a disconnect is not the only prime causative factor, as damage to these cortical structures also results in the same symptomology.
Background only. Canonical identity remains MONDO; clinical-trial relationships come from ClinicalTrials.gov.Drugs being studied
Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.