Disease & disorder

periodontitis

MONDO:0005076

An acute or chronic inflammatory process that affects the tissues that surround and support the teeth.

Clinical trials120
Recruiting8
Drug concepts studied6
Synonyms3

Disease research snapshot

CureCurrent currently links 120 distinct registered clinical trials to periodontitis through its MONDO disease mappings. 8 of those studies have the registry status “recruiting” (7%). These are registry statuses, not availability guarantees, study results or evidence of effectiveness.

The leading sponsor shown in this linked dataset is Ondokuz Mayıs University, associated with 5 distinct linked trials. This is a count of records, not a ranking of the sponsor's scientific quality.

The highest-count mapped research city in the current result is Ankara, Turkey (Türkiye). Only site locations available in the published registry projection are counted; some trial sites may be missing or outdated.

The most frequently mapped drug concept in the current linked trials is ascorbic acid 500 MG Oral Capsule (1 distinct trials). This describes what has been studied, not a recommended treatment.

Numbers are derived from CureCurrent's current ClinicalTrials.gov projection and conservative MONDO/RxNorm mappings. See sources, counting rules and limitations and verify eligibility or clinical findings with the original study record.

Research intelligence

Directly mapped studies only · unique clinical trials

Current registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.

Medications under investigation

Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.

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MONDO disease family

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Recruiting studies by city

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Trial status

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Trial phase

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Study start year

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Investigated drug interventions

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Background context

Periodontal disease

Periodontal disease, also known as gum disease, is a set of inflammatory conditions affecting the tissues surrounding the teeth. In its early stage, called gingivitis, the gums become swollen and red and may bleed. It is considered the main cause of tooth loss for adults worldwide. In its more serious form, called periodontitis, the gums can pull away from the tooth, bone can be lost, and the teeth may loosen or fall out. Halitosis (bad breath) may also occur. Periodontal disease typically arises from the development of plaque biofilm, which harbors harmful bacteria such as Porphyromonas gingivalis and Treponema denticola. These bacteria infect the gum tissue surrounding the teeth, leading to inflammation and, if left untreated, progressive damage to the teeth and gum tissue. Recent meta-analysis have shown that the composition of the oral microbiota and its response to periodontal disease differ between men and women. These differences are particularly notable in the advanced stages of periodontitis, suggesting that sex-specific factors may influence susceptibility and progression. Factors that increase the risk of disease include smoking, diabetes, HIV/AIDS, and almost any autoimmune disease, family history, high levels of homocysteine in the blood and certain medications. Diagnosis is by inspecting the gum tissue around the teeth both visually and with a probe and X-rays looking for bone loss around the teeth. Treatment involves good oral hygiene and regular professional teeth cleaning. Recommended oral hygiene include daily brushing and flossing. In certain cases ant...

Background only. Canonical identity remains MONDO; clinical-trial relationships come from ClinicalTrials.gov.

Clinical trials

40 shown
Salivary Apelin, Chemerin, Ghrelin, and Lipocalin-2 Levels in Diabetic Patients With PeriodontitisNCT07703345 · 2026-07-01
RECRUITING
Periodontal Disease in Rare Renal Disorders (PERIO-RA-RE)NCT07575347 · 2026-05-04
RECRUITING
Effects of Periodontal Treatment Associated With Antimicrobial Photodynamic Therapy on Halitosis in Patients With Diabetes MellitusNCT07463859 · 2026-04-02
RECRUITING
Regular Use of aPDT in the Management and Prevention of Periodontitis Symptoms in Diabetic PatientsNCT06486012 · 2025-01-23
RECRUITING
Extending Dental Care to Nursing Home Residents to Reduce Mouth Infections and Incidence of Pneumonia and Improve Diabetic Glucose ControlNCT06890676 · 2024-03-01
RECRUITING
Effects of Adjunct Antimicrobial Photodynamic Therapy in Periodontal Treatment of Patients With ObesityNCT06073704 · 2023-10-09
RECRUITING
Periodontitis and InflammationNCT04831060 · 2023-02-15
RECRUITING
Nalysis of the Periodontal Microbiota in Elderly Subjects With and Without Alzheimer's Disease: a Case Control StudyNCT05077618 · 2023-01-30
RECRUITING
Obesity and Oral Diseases in Adult PatientsNCT04602572 · 2026-11-01
NOT_YET_RECRUITING
Integrated Diabetes and Oral Health Care in OmanNCT07809477 · 2026-09-01
NOT_YET_RECRUITING
Adjunctive Hyaluronic Acid Gel in Non-Surgical Periodontal Treatment of Patients With Diabetes MellitusNCT07631273 · 2026-06-01
NOT_YET_RECRUITING
Periodontal Inflammation and Epigenetics in Obese IndividualsNCT07610902 · 2026-05-25
NOT_YET_RECRUITING
Evaluation of the Effects of Levodopa-Benserazide Drug Combination on Periodontal Status in Patients With Parkinson's DiseaseNCT07405268 · 2026-02-10
ACTIVE_NOT_RECRUITING
Periodontal Health Profile in Multiple Sclerosis PatientsNCT07412431 · 2026-02-03
NOT_YET_RECRUITING
Subgingival Lactobacillus Reuteri as an Adjunct to Non-Surgical Periodontal Therapy in Diabetic PatientsNCT07652255 · 2025-11-14
COMPLETED
GLP1-RA and PeriodontitisNCT07182123 · 2025-10-24
NOT_YET_RECRUITING
Optical Coherence Tomography Findings Associated With the Glaucoma-periodontitis StageNCT07853469 · 2025-10-06
COMPLETED
Investigation of the Relationship Between Periodontitis and Alzheimer's Disease in Terms of Blood ParametersNCT07069244 · 2025-08-05
COMPLETED
Para-Probiotic Oral Care in Periodontal Patients With Type 2 DiabetesNCT07069166 · 2025-07-30
COMPLETED
Effects of Nonsurgical Periodontal Treatment on GCF Calprotectin and IL-10 in Rheumatoid ArthritisNCT07844564 · 2025-07-17
COMPLETED
Periodontitis Treatment and Heart FailureNCT07036289 · 2025-06-10
ACTIVE_NOT_RECRUITING
Effect of Non-surgical Periodontal Therapy in Hypertensive Patients With Assessment of Endocan and TNF-α Levels in GCFNCT06627192 · 2025-03-10
NOT_YET_RECRUITING
Periodontitis Severity in Patients With Diabetic RetinopathyNCT07137013 · 2025-02-24
COMPLETED
Relationship Between Diabetes and PeriodontitisNCT07193979 · 2024-11-01
COMPLETED
Study of the Causal Link Between Rheumatoid Arthritis and Periodontitis Using Mendelian RandomizationNCT06603207 · 2024-10-01
UNKNOWN
(DDS) in India: a Screening Tool to Identify Prediabetes and Undiagnosed Type 2 Diabetes in Dental SettingsNCT06453278 · 2024-09-01
UNKNOWN
Local Delivery of Lactobacillus Reuteri Probiotic as An Adjunct to Non-surgical Periodontal Therapy in Patients With Stage II, III, and IV Periodontitis and Type 2 Diabetes MellitusNCT07598656 · 2024-07-01
COMPLETED
Salivary and Serum Inflammatory Biomarkers in Diabetic Nephropathy by Periodontal StatusNCT07498894 · 2024-06-10
COMPLETED
Treatment of Periodontal Disease in Patients With Alzheimer's DiseaseNCT05183321 · 2024-06-01
NOT_YET_RECRUITING
Evaluation of Chlorhexidine Gel Associated with Photodynamic Therapy in the Treatment of Chronic Periodontitis in Type 2 DiabeticsNCT06469294 · 2024-05-30
COMPLETED
Impact of Periodontal Therapy on Mental Health ParametersNCT06036472 · 2024-03-14
UNKNOWN
Nuclear Abnormalities in Gingival Epithelial Cells in Relation to Periodontal DiseaseNCT07375719 · 2024-03-01
COMPLETED
Relationship Between Major Depression and Periodontal DiseasesNCT05950009 · 2024-02-20
UNKNOWN
The Effect of Non-Surgical Periodontal Therapy on Rheumatoid ArthritisNCT06245265 · 2024-01-01
COMPLETED
EFFECT OF PERIODONTAL TREATMENT ON ALZHEIMER DISEASE-ASSOCIATED OUTCOMESNCT07233512 · 2023-11-17
ENROLLING_BY_INVITATION
Clinical and Prognostic Significance of Periodontitis in Patients With Arterial HypertensionNCT07593768 · 2023-10-10
ACTIVE_NOT_RECRUITING
Effect of Periodontal Treatment on Metabolic Control in Patients with Type-2 Diabetes Mellitus Treated in the Cardiovascular Healt ProgramNCT06895980 · 2023-08-22
UNKNOWN
Omega-3 Pufa and Aspirin as Adjunctive Therapy in Treatment of Smoker Patients With Stage Iii PeriodontitisNCT07385300 · 2023-08-20
COMPLETED
EVALUATION of GINGIVAL CREVICULAR FLUID and SERUM ASPROSIN LEVELS in OBESE and NORMAL-WEIGHT INDIVIDUALS with PERIODONTITISNCT06879951 · 2023-08-08
COMPLETED
Lactobacillus Reuteri for Non-surgical Periodontal Treatment of Chronic Periodontitis With Type 2 Diabetes PatientsNCT05275803 · 2023-06-08
UNKNOWN

How to interpret this record

CureCurrent links normalized diseases, medicines, registry study labels, sponsors and research sites. A link is not the same as a finding of clinical effectiveness. Our research guides explain how to compare studies, decode RxNorm identities, and avoid over-interpreting site and trial counts. See the published database coverage for mapping completeness.

Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.