Disease & disorder

pulmonary fibrosis

MONDO:0002771

Chronic progressive interstitial lung disorder characterized by the replacement of the lung tissue by connective tissue, leading to progressive dyspnea, respiratory failure, or right heart failure. Causes include chronic inflammatory processes, exposure to environmental irritants, radiation therapy, autoimmune disorders, certain drugs, or it may be idiopathic (no identifiable cause).

Clinical trials49
Recruiting5
Drug concepts studied2
Synonyms1

Research intelligence

Directly mapped studies only · unique clinical trials

Current registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.

Medications under investigation

Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.

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MONDO disease family

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Recruiting studies by city

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Investigated drug interventions

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Clinical trials

40 shown
Application of [68Ga]Ga-NI-FAPI-04 PET/CT Imaging in Fibroblast Activation Protein Related DiseasesNCT07464132 · 2025-12-17
RECRUITING
Routine vs On-demand ECMO for Lung TransplantationNCT06615492 · 2024-11-05
RECRUITING
Identification of Multiple Pulmonary Diseases Using Volatile Organic Compounds Biomarkers in Human Exhaled BreathNCT06528418 · 2024-06-30
RECRUITING
Preliminary Evaluation of [68Ga]CBP8 in Healthy Individuals, Lung Cancer, and Idiopathic Pulmonary Fibrosis PatientsNCT03535545 · 2018-08-01
RECRUITING
Role of Genetic Factors in the Development of Lung DiseaseNCT00001532 · 1996-09-13
RECRUITING
Clinical Outcomes and Immunotherapy in Lung Cancer With Pulmonary FibrosisNCT07396467 · 2025-11-01
ACTIVE_NOT_RECRUITING
Physical Exercise Program for Adults With Diffuse Interstitial Lung Disease in a Pulmonary Rehabilitation ContextNCT07061873 · 2024-10-01
ENROLLING_BY_INVITATION
Frequency-time Analysis of Pathological Lung Sounds: Detection and Quantification of Pathological Sounds in Patients With Cystic Fibrosis, Pulmonary Fibrosis or COPD (Chronic Obstructive Pulmonary Disease)NCT06399094 · 2024-07-18
TERMINATED
Infusion of Allogeneic Stromal Mesenchymal Stem Cells From Wharton´s Jelly in Patients With Diffuse Cutaneous Systemic Sclerosis With Refractory Pulmonary Involvement to TreatmentNCT07542067 · 2024-05-15
COMPLETED
A Study Evaluating the Safety and Efficacy of Inhaled AP01 in Participants With Progressive Pulmonary FibrosisNCT06329401 · 2024-04-03
ACTIVE_NOT_RECRUITING
Exercise Tolerance and Lower-limb Muscle Power in Patients With Chronic Respiratory DiseaseNCT06124859 · 2023-11-01
UNKNOWN
Evaluating the Potential of Large Language Models for Respiratory Disease ConsultationsNCT06457269 · 2023-10-01
COMPLETED
Telehealth and Onsite Maintenance Exercise in Chronic Lung DiseaseNCT06304207 · 2023-09-01
UNKNOWN
Pulmonary Rehabilitation in Non-chronic Obstructive Pulmonary Disease Patients.NCT05174741 · 2023-04-01
UNKNOWN
A Study to Evaluate the Safety, Tolerability and Pharmacokinetic Properties of 9MW3811 in Healthy SubjectsNCT05740475 · 2023-03-20
COMPLETED
A Multicenter Clinical Trial of Sputum DNA Testing for Lung Cancer in ChinaNCT05337163 · 2022-02-25
COMPLETED
Global Utilization And Registry Database for Improved preservAtion of doNor LUNGsNCT04930289 · 2021-10-15
ENROLLING_BY_INVITATION
Multiple Breath Washout as a Method for Diagnosing Lung DiseasesNCT06179342 · 2021-06-21
COMPLETED
Rheumatoid Arthritis-Associated Interstitial Lung Disease: Characterization of Lung Disease ProgressionNCT04136223 · 2021-03-01
UNKNOWN
A Study to Assess Pulsed Inhaled Nitric Oxide in Subjects With Pulmonary Fibrosis at Risk for Pulmonary HypertensionNCT03267108 · 2020-12-14
TERMINATED
Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung DisordersNCT02748798 · 2020-11-10
TERMINATED
A Dose Escalation Study to Assess the Safety and Efficacy of Pulsed Inhaled Nitric Oxide in Subjects With Pulmonary Fibrosis or SarcoidosisNCT03727451 · 2019-01-30
COMPLETED
Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung DiseaseNCT03455686 · 2018-04-19
UNKNOWN
A Study to Assess Pulsed Inhaled Nitric Oxide in Subjects With Pulmonary Hypertension Associated With Pulmonary FibrosisNCT05747508 · 2017-12-29
UNKNOWN
Accuracy of Spircare Device as Compared to the Conventional PlethysmographNCT03056066 · 2017-07-31
UNKNOWN
Oral Treprostinil in Subjects With Pulmonary Hypertension Associated With Pulmonary FibrosisNCT02603068 · 2016-02-01
WITHDRAWN
Clinical Outcomes and Molecular Phenotypes in Smokers With Parenchymal Lung DiseaseNCT02055222 · 2014-10-14
COMPLETED
Ex-vivo Perfusion and Ventilation of Lungs Recovered From Non-Heart-Beating Donors to Assess Transplant SuitabilityNCT01615484 · 2013-09-01
COMPLETED
Autologous CD117+ Progenitor Cell Mobilization for Lung TransplantationNCT01916577 · 2013-08-01
COMPLETED
Assessment of Pulmonary Specialty Physicians' Approach to Advanced Care Planning in Patients With Chronic Pulmonary DiseasesNCT01825538 · 2013-02-01
COMPLETED
Clinical and Pathophysiological Investigations Into Erdheim Chester DiseaseNCT01417520 · 2011-08-01
COMPLETED
Phase 2 Study of Ex-vivo Perfusion and Ventilation of Lungs to Assess Transplant SuitabilityNCT01241942 · 2010-12-01
TERMINATED
Comparative Study of 3 Portable Oxygen Concentrators During a 6-minute Walk Test in Patients With Chronic Lung DiseaseNCT01653730 · 2010-02-01
COMPLETED
Neoadjuvant Therapy for Esophageal Cancer and Cardiopulmonary PhysiologyNCT03462524 · 2010-01-01
COMPLETED
Trial of Concurrent Versus Sequential Tamoxifen With Radiotherapy in Breast Cancer PatientsNCT00896155 · 2008-12-01
UNKNOWN
Interferon-alpha Treatment of Chronic Cough in Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary FibrosisNCT00690885 · 2008-06-01
TERMINATED
Sildenafil Trial of Exercise Performance in Idiopathic Pulmonary FibrosisNCT00517933 · 2007-08-01
COMPLETED
Trial of Iloprost in Pulmonary Hypertension Secondary to Pulmonary FibrosisNCT00439543 · 2007-03-01
UNKNOWN
Written Disclosure Therapy for Anxiety and Stress in Patients With Chronic Lung DiseaseNCT00911794 · 2007-01-01
COMPLETED
Role of Helicobacter Pylori and Its Toxins in Lung and Digestive System DiseasesNCT00366509 · 2006-09-18
COMPLETED

Leading sponsors

National Heart, Lung, and Blood Institute (NHLBI)7Bellerophon3National Human Genome Research Institute (NHGRI)2University of North Carolina, Chapel Hill2Actelion1Ainos, Inc. (f/k/a Amarillo Biosciences Inc.1Avalyn Pharma Inc.1Bellerophon Pulse Technologies1Centre hospitalier de l'Université de Montréal (CHUM)1ChromX Health1Creative Biosciences (Guangzhou) Co., Ltd.1Duke University1Fundación Neumologica Colombiana1Groupe Hospitalier de la Region de Mulhouse et Sud Alsace1Hospital do Coracao1

Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.