renal artery obstruction
MONDO:0006945
Narrowing or occlusion of the renal artery or arteries. It is due usually to atherosclerosis; fibromuscular dysplasia; thrombosis; embolism, or external pressure. The reduced renal perfusion can lead to renovascular hypertension (hypertension, renovascular).
Research intelligence
Directly mapped studies only · unique clinical trialsCurrent registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.
Medications under investigation
Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.
MONDO disease family
Recruiting studies by city
Trial status
Trial phase
Study start year
Investigated drug interventions
Renal artery stenosis
Renal artery stenosis (RAS) is the narrowing of one or more of the renal arteries, which can reduce kidney blood flow and may lead to hypertension and kidney disease. RAS is often caused by atherosclerosis (approximately 90%) which is related to hypertension, high cholesterol, and smoking, or other rarer disease processes such as fibromuscular dysplasia (approximately 10%). The narrowing of one or more renal arteries can impede blood flow to a kidney, which the kidney can interpret as hypoperfusion (decreased or inadequate blood flow to an organ or tissue), and through a cascade of events involving activation of the Renin Angiotensin Aldosterone System (RAAS) may result in renovascular hypertension – a secondary type of high blood pressure. Possible complications of renal artery stenosis are chronic kidney disease, kidney atrophy, resistant hypertension, cardiovascular events such as coronary artery disease and stroke, and fluid retention, often manifesting as lower extremity edema.
Background only. Canonical identity remains MONDO; clinical-trial relationships come from ClinicalTrials.gov.Drugs being studied
Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.