sciatica
MONDO:0024333
A condition characterized by pain radiating from the back into the buttock and posterior/lateral aspects of the leg. Sciatica may be a manifestation of sciatic neuropathy; radiculopathy (involving the spinal nerve roots; L4, L5, S1, or S2, often associated with intervertebral disk displacement); or lesions of the cauda equina.
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Directly mapped studies only · unique clinical trialsCurrent registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.
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Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.
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Sciatica
Sciatica is pain going down the leg from the lower back. This pain may extend down the back, outside, or front of the leg. The onset is often sudden following activities such as heavy lifting, although it may also occur gradually. The pain is often described as shooting. Typically, symptoms occur on only one side of the body; certain causes, however, may result in pain on both sides. Lower back pain is sometimes present. Weakness or numbness may occur in different parts of the affected leg and foot. About 90% of sciatica is due to a spinal disc herniation pressing on one of the lumbar or sacral nerve roots. Spondylolisthesis, spinal stenosis, piriformis syndrome, pelvic tumors, and pregnancy are other possible causes of sciatica. The straight-leg-raising test is often helpful in diagnosis. The test is positive if, when the leg is raised while a person is lying on their back, pain shoots below the knee. In most cases medical imaging is not needed. However, imaging may be obtained if bowel or bladder function is affected, there is significant loss of feeling or weakness, symptoms are long standing, or there is a concern for tumor or infection. Conditions that can present similarly are diseases of the hip and infections such as early shingles (prior to rash formation). Initial treatment typically consists of pain medications. However, evidence for effectiveness of pain medication, and of muscle relaxants, is lacking. It is generally recommended that people continue with normal activity to the best of their abilities. Often all that is required for resolution of sciatica is...
Background only. Canonical identity remains MONDO; clinical-trial relationships come from ClinicalTrials.gov.Drugs being studied
Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.