Disease & disorder

somatization disorder

MONDO:0001830

Disorders having the presence of physical symptoms that suggest a general medical condition but that are not fully explained by a another medical condition, by the direct effects of a substance, or by another mental disorder. The symptoms must cause clinically significant distress or impairment in social, occupational, or other areas of functioning. In contrast to factitious disorders and malingering, the physical symptoms are not under voluntary control. (apa, dsm-V)

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Research intelligence

Directly mapped studies only · unique clinical trials

Current registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.

Medications under investigation

Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.

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Background context

Somatic symptom disorder

Somatic symptom disorder (SSD) is a mental disorder characterized by an excessive focus on physical symptoms—such as pain or shortness of breath—that cause significant distress or impairment. Individuals with SSD experience disproportionate thoughts, emotions, and behaviors related to their symptoms. The symptoms themselves are not deliberately produced or feigned (as they are in malingering and factitious disorders), and their underlying cause—whether organic, psychogenic or unexplained—is irrelevant to the diagnosis. Manifestations of somatic symptom disorder are variable; symptoms can be widespread, specific, and often unstable. Somatic symptom disorder corresponds to how an individual views and reacts to symptoms rather than the symptoms themselves, and it can develop in the setting of existing chronic illness or newly onset conditions. Several studies have found a high frequency of comorbidity with major depressive disorder, generalized anxiety disorder, and phobias. Somatic symptom disorder is frequently associated with functional pain syndromes, such as fibromyalgia and irritable bowel syndrome (IBS). Somatic symptom disorder typically leads to poor overall functioning, interpersonal issues, unemployment or problems at work, and financial strain as a result. The etiology of somatic symptom disorder is unknown. Symptoms may result from a heightened awareness of specific physical sensations alongside health anxiety. There is some controversy surrounding the diagnosis, since symptom perception and response are inherently subjective, and may depend on the clinician's...

Background only. Canonical identity remains MONDO; clinical-trial relationships come from ClinicalTrials.gov.

Drugs being studied

Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.