Disease & disorder

substance abuse

MONDO:0002491

The use of a drug for a reason other than which it was intended or in a manner or in quantities other than directed.

Clinical trials66
Recruiting2
Drug concepts studied6
Synonyms0

Research intelligence

Directly mapped studies only · unique clinical trials

Current registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.

Medications under investigation

Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.

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Recruiting studies by city

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Trial status

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Investigated drug interventions

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Background context

Substance abuse

Substance use, also known as drug use or, in older vernacular, substance abuse, is the use of a drug in amounts or by methods that are harmful to the individual or others. It is a health issue. It is a form of substance-related disorder. Differing definitions of drug misuse are used in public health, medical, and criminal justice contexts. In some cases, criminal or anti-social behavior occurs when some persons are under the influence of a drug, and may result in long-term personality changes in individuals. In addition to possible physical, social, and psychological harm, the use of some drugs may also lead to criminal penalties, although these vary widely depending on the local jurisdiction. Drugs most often associated with this term include alcohol, amphetamines, barbiturates, benzodiazepines, cannabis, cocaine, hallucinogens, methaqualone, and opioids. The exact cause of substance abuse is sometimes unclear, but there are two predominant theories: either a genetic predisposition or a habit learned or passed down from others, which, if addiction develops, manifests itself as a possible chronic debilitating disease. It is not easy to determine why a person misuses drugs, as there are multiple environmental factors to consider. These factors include not only inherited biological influences (genes), but there are also mental health stressors such as overall quality of life, physical or mental abuse, luck and circumstance in life, and early exposure to drugs, all play a significant role in how people will respond to drug use. In 2010, about 5% of adults (230 million) used...

Background only. Canonical identity remains MONDO; clinical-trial relationships come from ClinicalTrials.gov.

Clinical trials

40 shown
The Trans-Led Care StudyNCT06880705 · 2026-04-14
RECRUITING
SER Familia: A Family-Based Intervention Addressing Syndemic Conditions Among Latino Immigrant FamiliesNCT06627764 · 2025-06-30
RECRUITING
Testing a Mobile Health Application to Improve HIV Prevention and Substance Use Treatment Among Women Involved in the Carceral SystemNCT07432555 · 2026-10-20
NOT_YET_RECRUITING
Comparison of the Italian and U.S. Forensic Models for Dual-diagnosis Offenders: a 3-year Longitudinal StudyNCT07585656 · 2026-06-01
NOT_YET_RECRUITING
Kentucky Outreach Service Kiosk (KyOSK): Reducing HIV, HCV, and Overdose RiskNCT05657106 · 2023-03-06
ACTIVE_NOT_RECRUITING
Electronic SBI(RT) for MSM in ArgentinaNCT05542914 · 2022-11-01
TERMINATED
Addressing Risk Through Community Treatment for Infectious Disease and Opioid Use Disorder Now (ACTION) Among Justice-involved PopulationsNCT05286879 · 2022-03-31
COMPLETED
Cost-effectiveness of the Care PathwaysNCT04619836 · 2020-06-26
ENROLLING_BY_INVITATION
To Reach Unrestricted Services for Transgender WomenNCT03877497 · 2019-09-19
COMPLETED
Perinatal Mental Health Care in SwitzerlandNCT04185896 · 2019-07-10
UNKNOWN
Hispanic Men Building Respect Education and Safety/ HoMBRES Manteniendo Respeto, Educacion y Seguridad.NCT03730987 · 2019-04-19
COMPLETED
OPTIONS: A Patient-Centered HIV Prevention Decision Aid for PrEP Uptake for Women With Substance Use in Treatment SettingsNCT03651453 · 2018-10-15
COMPLETED
Integrated BA and HIV RR Counseling for MSM With Stimulant AbuseNCT03175159 · 2018-03-01
COMPLETED
Health and Justice: A Continuum of Care for HIV and SU for Justice-Involved Young Adults (PHASE 2)NCT03369249 · 2017-12-09
COMPLETED
Testing an Integrated Bio-Behavioral Primary HIV Prevention Intervention Among High-Risk People Who Use DrugsNCT03282890 · 2017-11-20
COMPLETED
Development and Preliminary Trial of a Brief, Portable Health Intervention for Rural Sexual Minority Emerging AdultsNCT03751020 · 2017-10-27
COMPLETED
Integrated Care (iCare) at Mount Sinai to Improve Substance Use Diagnosis and Treatment Practices in HIV Clinic SettingsNCT03092596 · 2017-02-02
COMPLETED
Victim Impact Modules for Jail InmatesNCT01381146 · 2016-07-15
WITHDRAWN
Implementation Research for Vulnerable Women in South AfricaNCT02733003 · 2015-09-01
COMPLETED
Understanding Substance Use and Incident HIV/STI Among Young Black MSMNCT02503618 · 2015-07-01
COMPLETED
Feasibility of Interventions on People Who Inject Drugs in VietnamNCT02573948 · 2014-09-01
COMPLETED
Young Women's Health CoOp (Cooperative) in Cape TownNCT02677025 · 2014-05-01
COMPLETED
Enhanced Access to HIV Care for Drug Users in San Juan, Puerto RicoNCT01792752 · 2013-12-20
COMPLETED
Effect Evaluation of Individual Placement and Support (IPS)NCT01964092 · 2013-05-01
COMPLETED
Project RETAIN: Providing Integrated Care for HIV-Infected Crack Cocaine UsersNCT01614106 · 2013-01-01
COMPLETED
Targeting PM to Improve HIV Adherence in Adolescents at Risk for Substance AbuseNCT01959217 · 2012-12-13
COMPLETED
Reducing High Risk Behavior in Treatment CourtNCT01481428 · 2012-09-01
COMPLETED
Hospital Visit as Opportunity for Prevention and Engagement for HIV-Infected Drug UsersNCT01612169 · 2012-07-01
COMPLETED
WHC+ (Women's Health CoOp PLUS)NCT01497405 · 2012-05-01
COMPLETED
Substance Treatment and HIV Testing and Referral SystemNCT01488630 · 2011-12-01
COMPLETED
A Self-Assessment Intervention for Young Adult Polydrug Users at Risk for HIVNCT01362634 · 2011-08-01
COMPLETED
Seek, Test, and Retain. Linkages for Black HIV+, Substance-Using MSMNCT01790360 · 2011-07-01
COMPLETED
Evaluation of Re-Entry Values and Mindfulness Program (REVAMP) With Jail InmatesNCT01378923 · 2011-04-01
UNKNOWN
Clinical Intervention Psychosis and AddictionNCT01411566 · 2011-01-01
UNKNOWN
Adherence to HIV Therapy in Heroin Addicts: Oral vs XR-NTXNCT01101815 · 2010-06-01
COMPLETED
Young Women's CoOp StudyNCT01224184 · 2010-05-01
COMPLETED
Using Incentives to Improve Parolee Participation and Attendance in Community TreatmentNCT01090245 · 2010-04-01
COMPLETED
Stonewall Treatment Evaluation ProjectNCT01129401 · 2010-03-01
COMPLETED
Juvenile Offender HIV Prevention and Drug Abuse ServicesNCT01922297 · 2010-01-01
COMPLETED
Screening Protocol for Research ParticipantsNCT01010620 · 2009-12-01
COMPLETED

Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.