tenosynovial giant cell tumor
MONDO:0002522
A tumor usually arising in the synovium of joints, bursa or tendon sheath. It is characterized by the presence of mononuclear cells, multinucleated osteoclast-like giant cells, hemosiderin-laden macrophages, foam cells, and an inflammatory infiltrate. According to the growth pattern, it is classified as localized or diffuse.
Research intelligence
Directly mapped studies only · unique clinical trialsCurrent registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.
Medications under investigation
Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.
MONDO disease family
Recruiting studies by city
Trial status
Trial phase
Study start year
Investigated drug interventions
Tenosynovial giant cell tumor
Tenosynovial giant cell tumor (TGCT) is a non-malignant tumor defined histologically as inclusions of "osteoclast-like" multinucleated giant cells, hemosiderin, and macrophages. This histology can present one of 2 clinically distinct ways. Localized/nodular TGCT (L-TGCT), sometimes referred to as "giant cell tumor of the tendon sheath"; is a common tumor that presents as a slow-growing, encapsulated, localized and limited bump, most frequently in the fingers. Diffuse TGCT (D-TGCT) — also called pigmented villonodular synovitis (PVNS)— is a rare tumor that presents as a proliferative, destructive, intra-articular lesion, most commonly in the knee. D-TGCT tumors often develop from the lining of joints (also known as synovial tissue).. Common symptoms of D-TGCT include swelling, pain, stiffness and reduced mobility in the affected joint or limb.
Background only. Canonical identity remains MONDO; clinical-trial relationships come from ClinicalTrials.gov.Drugs being studied
Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.