thrombocythemia 2
MONDO:0011173
Familial thrombocytosis in which the cause of the disease is a mutation in the MPL gene that produces constitutive activation of the thrombopoietin receptor, leading to excessive megakaryocyte proliferation and elevated platelet counts. Affected individuals exhibit sustained thrombocythemia, which may be accompanied by thrombotic or hemorrhagic complications and, in rare cases, leukemic transformation.
Research intelligence
Directly mapped studies only · unique clinical trialsCurrent registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.
Medications under investigation
Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.
MONDO disease family
Recruiting studies by city
Trial status
Trial phase
Study start year
Investigated drug interventions
Drugs being studied
Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.