Disease & disorder

vaginismus

MONDO:0021723

Tightness of the vaginal wall during vaginal penetration including sexual intercourse. It is caused by involuntary spasm of the pelvic floor muscles, and results in painful intercourse or failure to have intercourse. It may due to psychological conditions, trauma in the vaginal area, or vaginal infection.

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Research intelligence

Directly mapped studies only · unique clinical trials

Current registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.

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Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.

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Background context

Vaginismus

Vaginismus is a condition in which involuntary muscle spasm interferes with vaginal intercourse or other penetration of the vagina. This often results in pain with attempts at sex. Often it begins when vaginal intercourse is first attempted. Vaginismus may be considered an older term for pelvic floor dysfunction. The formal diagnostic criteria specifically require interference during vaginal intercourse and a desire for intercourse, but the term vaginismus is sometimes used more broadly to refer to any muscle spasm occurring during the insertion of objects into the vagina, sexually motivated or otherwise, including speculums and tampons. The underlying cause is generally a fear that penetration will hurt. Risk factors include a history of sexual assault, endometriosis, vaginitis, or a prior episiotomy. Diagnosis is based on the symptoms and examination. It requires there to be no anatomical or physical problems (e.g., pelvic floor dysfunction, vulvodynia, vestibulodynia, etc.) and a desire for penetration. Treatment may include behavior therapy such as graduated exposure therapy and gradual vaginal dilation. Surgery is not generally indicated. Botulinum toxin (botox), a muscle spasm treatment, is being studied. There are no epidemiological studies of the prevalence of vaginismus. Estimates of how common the condition is are varied. One textbook estimates that 0.5% of women are affected, but rates in clinical settings indicate that 5–17% of women experience vaginismus. Outcomes are generally good with treatment.

Background only. Canonical identity remains MONDO; clinical-trial relationships come from ClinicalTrials.gov.

Drugs being studied

Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.