Disease & disorder

visual snow syndrome

MONDO:0018486

Visual snow syndrome is described as a persistent visual problem characterized by seeing snow-like dots. Migraines are a common symptom. Many people also see drifting blobs of varying size and shape (floaters), visual effects (entopic phenomenon), glare, halos, starbursts, trails, odd colors and shapes, and may have persistent recurrence of a visual image (palinopsia) and double vision. Additional symptoms may include fatigue, tinnitus, or depersonalization and depression. Most people have normal vision tests and normal brain images. Standard migraine treatments are often not helpful. There is no cure or effective treatment to completely relieve the symptoms, but medication seems to help some people with visual snow.

Clinical trials0
Recruiting0
Drug concepts studied0
Synonyms1

Research intelligence

Directly mapped studies only · unique clinical trials

Current registry observations. Phase counts may overlap. Study start dates are not registry registration dates. Investigational interventions are not approved-treatment recommendations.

Medications under investigation

Verified disease and drug mappings that co-occur within the same study; not evidence of effectiveness.

Loading mapped interventions…

MONDO disease family

Loading verified ontology relationships…

Recruiting studies by city

Loading research-site locations…

Trial status

Loading…

Trial phase

Loading…

Study start year

Loading…

Investigated drug interventions

Loading…
Background context

Visual snow syndrome

Visual snow syndrome (VSS) (coined by Liu et al in 1995) is a neurological condition in which the primary symptom is persistent flickering white, black, transparent, or colored dots across the entire visual field. It is distinct from the symptom of visual snow itself, which may be caused by multiple ophthalmic and vascular conditions. Other common symptoms include palinopsia, enhanced entoptic phenomena, photophobia, and tension headaches. The condition is typically always present and has no known cure, as viable treatments are still under research. Migraines and tinnitus are common comorbidities that are both associated with a more severe presentation of the syndrome. The cause of the syndrome is unclear. The underlying mechanism is believed to involve excessive excitability of neurons in the right lingual gyrus and left anterior lobe of the cerebellum. Another hypothesis proposes that visual snow syndrome could be a type of thalamocortical dysrhythmia and may involve the thalamic reticular nucleus (TRN). A failure of inhibitory action from the TRN to the thalamus may be the underlying cause for the inability to suppress excitatory sensory information. Another existing theory is that visual snow syndrome is caused by dysfunctional cortical visual processing, or failures in the visual processing in the eye's retina. Research has been limited due to issues of case identification, diagnosis, and the limited size of any studied cohort, though the issue of diagnosis is now largely addressed. Initial functional brain imaging research suggests visual snow is a brain disorder,...

Background only. Canonical identity remains MONDO; clinical-trial relationships come from ClinicalTrials.gov.

Drugs being studied

Disease identity and terminology: MONDO. Trial relationships: ClinicalTrials.gov.