Intervention

methotrexate

ClinicalTrials.gov intervention label

Clinical trials88
Recruiting0
Common conditions25
Lead sponsors shown15

Clinical trials

60 shown
Efficacy and Safety of Durvalumab in Non-Small Cell Lung Cancer With Leptomeningeal MetastasisNCT04356222 · 2020-06-01
UNKNOWN
A Study Comparing Biologics + Methotrexate With Biologics + Tacrolimus in Patients With Rheumatoid Arthritis (RA)NCT03737708 · 2019-02-13
COMPLETED
Effects of Antirheumatic Treatment on Levels of Survivin in Rheumatoid Arthritis PatientsNCT03440892 · 2017-11-01
UNKNOWN
BBBD Followed By Methotrexate and Carboplatin With or Without Trastuzumab in Treating Women With Breast Cancer That Has Spread to the BrainNCT00397501 · 2013-10-01
WITHDRAWN
A Study of Subcutaneous RoActemra/Actemra (Tocilizumab) as Monotherapy or in Combination With Methotrexate or Other Non-Biologic DMARDs in Patients With Active Rheumatoid ArthritisNCT01995201 · 2013-09-01
COMPLETED
A Study of The Effect of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate on Articular Damage in The Hand in Patients With Moderate to Severe Rheumatoid Arthritis Who Have an Inadequate Response to Non-Biological DMARDsNCT01878318 · 2013-06-01
WITHDRAWN
Single Ascending Dose Study of Safety and Tolerability of Sarilumab and Methotrexate in Japanese Patients With Rheumatoid ArthritisNCT01850680 · 2013-04-01
COMPLETED
Good EULAR Response In Patients With Early Rheumatoid ArthritisNCT01558089 · 2013-03-01
COMPLETED
To Evaluate The Safety of SAR153191 (REGN88) and Tocilizumab Added to Other RA Drugs in Patients With RA Who Are Not Responding to or Intolerant of Anti-TNF Therapy (SARIL-RA-ASCERTAIN)NCT01768572 · 2013-03-01
COMPLETED
To Evaluate The Effect Of SAR153191 (REGN88) Added To Other RA Drugs In Patients With RA Who Are Not Responding To Or Intolerant Of Anti-TNF Therapy (SARIL-RA-TARGET)NCT01709578 · 2012-10-01
COMPLETED
Acupuncture Study on Rheumatoid Arthritis, Monitoring Microbiome and BloodNCT01619176 · 2012-10-01
COMPLETED
A Study to Evaluate the Safety and Efficacy of ASP015K in Moderate to Severe Rheumatoid Arthritis Subjects Who Have Had an Inadequate Response to MethotrexateNCT01554696 · 2012-07-06
COMPLETED
Disease-Modifying Antirheumatic Drugs Cycle Combination Therapy ResearchNCT01617590 · 2012-05-01
UNKNOWN
A Study of RoActemra/Actemra (Tocilizumab) With or Without Methotrexate in Patients With Mild to Moderate Rheumatoid Arthritis With an Inadequate Response to MethotrexateNCT01587989 · 2012-02-01
COMPLETED
A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate Versus RoActemra/Actemra Monotherapy in Patients With Rheumatoid Arthritis and an Inadequate Response to MethotrexateNCT01399697 · 2011-09-01
COMPLETED
A Study on The Safety of Administering Rituximab at A More Rapid Rate in Patients With Rheumatoid ArthritisNCT01382940 · 2011-07-26
COMPLETED
Masitinib in Refractory Active Rheumatoid ArthritisNCT01410695 · 2011-07-01
TERMINATED
A Study of RoActemra/Actemra (Tocilizumab) Versus Adalimumab in Combination With Methotrexate (MTX) in Patients With Moderate to Severe Active Rheumatoid Arthritis And an Inadequate Response to Treatment With Only One Tumor Necrosis Factor (TNF)-InhibitorNCT01283971 · 2011-05-01
TERMINATED
Liposomal Cytarabine and High-Dose Methotrexate in Treating Patients With Central Nervous System Metastases From Breast CancerNCT00992602 · 2011-04-01
COMPLETED
A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Non-biologic DMARDsNCT01353859 · 2011-03-01
COMPLETED
A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Disease-Modifying Antirheumatic Drugs (DMARDs) (ALABASTER)NCT01235507 · 2011-02-01
COMPLETED
A Study to Evaluate the Efficacy and Safety of MLTA3698A in Combination With a Disease-Modifying Anti-Rheumatic Drug (DMARD) Compared With Adalimumab in Combination With a DMARD in Patients With Active Rheumatoid ArthritisNCT01225393 · 2010-11-01
COMPLETED
Study to Determine the Effects of Different Doses of Methotrexate (MTX) When Taken With Adalimumab in Subjects With Early Rheumatoid Arthritis (RA)NCT01185301 · 2010-10-01
COMPLETED
A Study of the Effects of RoActemra/Actemra on Vaccination in Patients With Rheumatoid Arthritis on Background Methotrexate (VISARA)NCT01163747 · 2010-09-01
COMPLETED
A Study of Efficacy of Rituximab [Mabthera/Rituxan] in Patients With Rheumatoid Arthritis Using Magnetic Resonance Imaging of the Hand (RESONAR)NCT01117129 · 2010-04-01
TERMINATED
A Drug Interaction Study to Evaluate the Pharmacokinetics of ASP015K and Methotrexate in Patients With Rheumatoid ArthritisNCT01754805 · 2010-01-22
COMPLETED
A Study of Tocilizumab and Methotrexate in Combination or as Monotherapy in Treatment-Naïve Patients With Early Rheumatoid ArthritisNCT01034137 · 2010-01-01
COMPLETED
A Study of Subcutaneously Administered Tocilizumab in Patients With Rheumatoid ArthritisNCT00965653 · 2009-08-01
COMPLETED
A Study of Tocilizumab and Methotrexate Treatment Strategies (Adding Tocilizumab to Methotrexate Versus Switching to Tocilizumab) in Patients With Active Rheumatoid Arthritis With Inadequate Response to Prior Methotrexate TreatmentNCT00810199 · 2009-03-01
COMPLETED
A Study to Assess the Effect of Tocilizumab Plus Methotrexate on Safety and Signs and Symptoms in Patients With Moderate to Severe Active Rheumatoid ArthritisNCT00754572 · 2009-02-01
COMPLETED
A Pilot Study of the Feasibility of Discontinuation of Adalimumab in Stable Rheumatoid Arthritis Patients in Clinical RemissionNCT00808509 · 2009-01-01
COMPLETED
A Study to Evaluate the Efficacy, Safety and Pharmacokinetics/Pharmacodynamics (PK/PD) of Ocrelizumab in Patients With Rheumatoid ArthritisNCT00779220 · 2008-10-01
TERMINATED
Study Evaluating Efficacy / Safety of Etanercept + Methotrexate Compared to Usual Treatment in Moderate RA SubjectsNCT00706797 · 2008-09-01
TERMINATED
Methotrexate Polyglutamate Levels as a Marker for the Clinical Outcome in the Treatment of Rheumatoid ArthritisNCT00695188 · 2008-05-01
COMPLETED
Cyclophosphamide, Methotrexate, and Prednisolone With or Without Aromatase Inhibitor Therapy in Treating Postmenopausal Women With Metastatic Breast CancerNCT00687648 · 2008-05-01
UNKNOWN
A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis and an Inadequate Response to MethotrexateNCT01000610 · 2008-03-17
COMPLETED
A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to MethotrexateNCT00934648 · 2007-10-01
COMPLETED
Rheumatoid Arthritis: Comparison of Active Therapies in Patients With Active Disease Despite Methotrexate TherapyNCT00405275 · 2007-07-01
COMPLETED
Trial of Early Aggressive Drug Therapy in Juvenile Idiopathic ArthritisNCT00443430 · 2007-05-01
COMPLETED
Bucillamine Study of Holding Remission After Infliximab Dose-offNCT00716248 · 2007-01-01
UNKNOWN
Study of the Optimal Protocol for Methotrexate and Adalimumab Combination Therapy in Early Rheumatoid ArthritisNCT00420927 · 2006-12-01
COMPLETED
Rituximab and Combination Chemotherapy in Treating Patients With Newly Diagnosed, HIV-Associated Burkitt's LymphomaNCT00392834 · 2006-09-01
COMPLETED
A Study of MabThera/Rituxan (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis and Inadequate Response to DMARD TherapyNCT02006706 · 2006-08-10
COMPLETED
Sunitinib, Cyclophosphamide, and Methotrexate in Treating Patients With Metastatic Breast CancerNCT00616122 · 2006-03-01
TERMINATED
A Study of Retreatment With Rituximab in Patients With Rheumatoid Arthritis Receiving Background MethotrexateNCT00266227 · 2006-01-01
COMPLETED
A Study to Evaluate Rituximab in Combination With Methotrexate in Methotrexate-Naive Patients With Active Rheumatoid ArthritisNCT00299104 · 2006-01-01
COMPLETED
Combination Chemotherapy in Treating Patients With Early Stage Breast Cancer That Has Been Removed By SurgeryNCT00301925 · 2005-12-16
UNKNOWN
A Study of the Safety and Efficacy of Rituximab in Patients With Moderate to Severe Rheumatoid Arthritis Receiving MethotrexateNCT00243412 · 2005-08-01
COMPLETED
Hormone Therapy and Combination Chemotherapy Before and After Surgery in Treating Patients With Stage I-IIIA Breast CancerNCT00194792 · 2005-08-01
TERMINATED
Liposomal Doxorubicin Compared With Observation or Cyclophosphamide and Methotrexate in Treating Older Women Who Have Undergone Surgery for Breast CancerNCT00296010 · 2005-08-01
TERMINATED
Remission and Joint Damage Progression in Early Rheumatoid ArthritisNCT00122382 · 2005-07-01
COMPLETED
Open-Label Steroid Reduction Study of Adalimumab With Methotrexate in Patients With Active Rheumatoid ArthritisNCT00233558 · 2005-06-01
TERMINATED
A Study of the Efficacy and Safety of Re-treatments With Rituximab in Patients With Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-tnfa TherapiesNCT02097745 · 2004-06-01
COMPLETED
Treatment of Early Aggressive Rheumatoid Arthritis (TEAR)NCT00259610 · 2004-05-01
COMPLETED
Combination Chemotherapy and Filgrastim Before Surgery in Treating Patients With HER2-Positive Breast Cancer That Can Be Removed By SurgeryNCT00194779 · 2003-10-01
COMPLETED
Triptorelin in Preventing Early Menopause in Premenopausal Women Who Are Receiving Chemotherapy for Stage I, Stage II, or Stage III Breast Cancer That Has Been Removed By SurgeryNCT00311636 · 2003-09-01
COMPLETED
Allogeneic Stem Cell Transplant After ATG, High-Dose Melphalan, and Fludarabine for Patients With Breast CancerNCT00074269 · 2003-07-01
TERMINATED
Adalimumab Administered in Korean Rheumatoid Arthritis Subjects Treated With MethotrexateNCT00235859 · 2003-07-01
COMPLETED
ELDA: Elderly Breast Cancer - Docetaxel in Adjuvant TreatmentNCT00331097 · 2003-07-01
COMPLETED
Metronomic Low-Dose Cyclophosphamide and Methotrexate With or Without Bevacizumab in Treating Women With Metastatic Breast CancerNCT00083031 · 2003-07-01
COMPLETED

Common conditions

Rheumatoid Arthritis43Breast Cancer29Lymphoma3Arthritis, Rheumatoid2Estrogen Receptor-positive Breast Cancer2Multiple Sclerosis2Progesterone Receptor-positive Breast Cancer2Recurrent Breast Cancer2Rheumatoid Arthritis (RA)2Stage II Breast Cancer2Stage IIIA Breast Cancer2Stage IV Breast Cancer2Brain and Central Nervous System Tumors1Breast Neoplasms1Central Nervous System Metastases1Cognitive/Functional Effects1Demyelinating Disorders1Drug/Agent Toxicity by Tissue/Organ1Durvalumab1Early Rheumatoid Arthritis1Estrogen Receptor-negative Breast Cancer1HER2-negative Breast Cancer1HER2-positive Breast Cancer1Juvenile Chronic Polyarthritis1Juvenile Idiopathic Arthritis1

Trial status mix

COMPLETED61
UNKNOWN12
TERMINATED10
WITHDRAWN4
SUSPENDED1

Phase mix

PHASE337
PHASE224
PHASE420
PHASE15
NA3

Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.