Intervention

letrozole

ClinicalTrials.gov intervention label

Clinical trials68
Recruiting0
Common conditions25
Lead sponsors shown15

Clinical trials

60 shown
Study of PF-07220060 With Letrozole in Adults With HR-positive HER2-negative Breast Cancer Who Have Not Received Anticancer Treatment for Advanced/Metastatic DiseaseNCT06760637 · 2025-01-06
ACTIVE_NOT_RECRUITING
A Study to Learn About the Study Medicine PF-07220060 Together With Letrozole Compared to Letrozole Alone in Women Post MenopauseNCT06465368 · 2024-07-11
COMPLETED
Letrozole Plus Metronomic Capecitabine as First-line Treatment for Patients With Recurrent or Metastatic Breast CancerNCT04942899 · 2023-08-30
UNKNOWN
Select the Appropriate Population for Adding CDK4/6i to Neoadjuvant Endocrine TherapyNCT05809024 · 2023-03-01
UNKNOWN
ONO-4578-06:Phase I Study of ONO-4578 and Letrozole Plus CDK4 /6 Inhibitors in Breast CancerNCT06570031 · 2021-11-09
COMPLETED
Randomized, Open Label, Clinical Study of the Targeted Therapy, Palbociclib, to Treat Metastatic Breast CancerNCT02947685 · 2017-06-21
ACTIVE_NOT_RECRUITING
A Companion Sample Collection Protocol to Support the Discovery of Breast Cancer Aberrations With Treatment of CDK4/6 Therapy/LEE011/RibociclibNCT03050398 · 2017-06-07
TERMINATED
Study for Women and Men With Hormone-receptor Positive Locally Advanced or Metastatic Breast CancerNCT03096847 · 2016-10-24
COMPLETED
Phase II Study of Everolimus Beyond ProgressionNCT02269670 · 2014-11-25
TERMINATED
TRial on the Endocrine Activity of Neoadjuvant DegarelixNCT02005887 · 2014-02-01
COMPLETED
A Pharmacodynamics Pre-surgical Study of LEE011 in Early Breast Cancer Patients (MONALEESA-1)NCT01919229 · 2013-10-01
TERMINATED
S1207 Hormone Therapy With or Without Everolimus in Treating Patients With Breast CancerNCT01674140 · 2013-09-12
ACTIVE_NOT_RECRUITING
BYL719 and Letrozole in Post-Menopausal Patients With Hormone Receptor-Positive Metastatic Breast CancerNCT01791478 · 2013-04-01
COMPLETED
Vorinostat in Treating Patients With Stage IV Breast Cancer Receiving Hormone TherapyNCT01720602 · 2012-11-01
COMPLETED
A Study Of Oral Palbociclib (PD-0332991), A CDK4/6 Inhibitor, As Single Agent In Japanese Patients With Advanced Solid Tumors Or In Combination With Letrozole For The First-Line Treatment Of Postmenopausal Japanese Patients With ER (+) HER2 (-) Advanced Breast CancerNCT01684215 · 2012-10-19
COMPLETED
Letrozole and Lapatinib Followed by Everolimus in Women With Advanced Breast CancerNCT01499160 · 2012-05-01
TERMINATED
Letrozole in Treating Postmenopausal Women With Ductal Carcinoma in SituNCT01439711 · 2012-02-01
COMPLETED
Goserelin and Letrozole or Anastrozole in Premenopausal Patients With Stage II-III Estrogen Receptor-Positive Breast CancerNCT01368263 · 2011-09-01
TERMINATED
Zoledronic Acid in Aromatase Inhibitor Induced Musculoskeletal SymptomsNCT01194440 · 2011-02-01
COMPLETED
Study of BMS-754807 Combined With Letrozole or BMS-754807 Alone in Patients With Hormone Receptor-Positive Breast Cancer and Resistance to Non-Steroidal Aromatase InhibitorsNCT01225172 · 2010-12-31
TERMINATED
Vorinostat in Treating Patients With Stage IV Breast Cancer Receiving Aromatase Inhibitor TherapyNCT01153672 · 2010-11-01
COMPLETED
RO4929097 and Letrozole in Treating Post-Menopausal Women With Hormone Receptor-Positive Stage II or Stage III Breast CancerNCT01208441 · 2010-11-01
TERMINATED
Panobinostat and Letrozole in Treating Patients With Metastatic Breast CancerNCT01105312 · 2010-09-01
COMPLETED
Letrozole in Preventing Breast Cancer in Healthy Postmenopausal Women at High Risk for Breast CancerNCT01077453 · 2010-03-01
COMPLETED
Phase 2, Endocrine Therapy + OSI-906 With or Without Erlotinib for Hormone-sensitive Metastatic Breast CancerNCT01013506 · 2009-08-01
WITHDRAWN
Pilot Study to Evaluate the Effect of Aromatase Inhibitor Therapy on Pain Threshold in Breast Cancer PatientsNCT01814397 · 2009-07-01
COMPLETED
Extended Endocrine Therapy for Premenopausal Women With Breast CancerNCT00903162 · 2009-05-01
COMPLETED
Letrozole, Anastrozole, Exemestane, or Tamoxifen Citrate in Treating Postmenopausal Women With Breast CancerNCT00893061 · 2009-03-16
COMPLETED
Letrozole or Tamoxifen Citrate in Treating Older Postmenopausal Women Undergoing Surgery for Breast CancerNCT00949598 · 2008-12-01
COMPLETED
Effect of Aromatase Inhibitors on Breast Magnetic Resonance Imaging (MRI)NCT01129622 · 2008-10-01
COMPLETED
Effect of Aromatase Inhibitor Therapy on Blood Vessel Function in Postmenopausal Women With Breast CancerNCT00719966 · 2008-09-18
COMPLETED
Study Of Letrozole With Or Without Palbociclib (PD-0332991) For The First-Line Treatment Of Hormone-Receptor Positive Advanced Breast CancerNCT00721409 · 2008-09-15
COMPLETED
Chemotherapy or Letrozole Before Surgery in Treating Postmenopausal Women With Breast Cancer That Can Be Removed By SurgeryNCT00963729 · 2008-09-01
COMPLETED
Letrozole in Preventing Breast Cancer in Postmenopausal Women With a BRCA1 or BRCA2 MutationNCT00673335 · 2008-05-01
COMPLETED
Cyclophosphamide, Methotrexate, and Prednisolone With or Without Aromatase Inhibitor Therapy in Treating Postmenopausal Women With Metastatic Breast CancerNCT00687648 · 2008-05-01
UNKNOWN
Fulvestrant With or Without Lapatinib and/or Aromatase Inhibitor Therapy in Treating Postmenopausal Women With Metastatic Breast Cancer That Progressed After Previous Aromatase Inhibitor TherapyNCT00688194 · 2008-05-01
UNKNOWN
Letrozole in Treating Postmenopausal Women With Stage I, II or III Breast Cancer That Can Be Removed by SurgeryNCT00651976 · 2008-03-01
TERMINATED
Study of Exemestane After Anastrozole or Letrozole Treatment of Postmenopausal Women With Hormone Responsive Breast CancerNCT00902954 · 2008-03-01
UNKNOWN
Rheumatological Evaluation of Anastrozole and Letrozole as Adjuvant Treatment in Post-menopausal Women With Breast CancerNCT00688909 · 2008-03-01
COMPLETED
Bioequivalency Study of Letrozole 2.5 mg Tablets Under Fed ConditionsNCT01367626 · 2008-03-01
COMPLETED
Sorafenib and Letrozole, Anastrozole, or Exemestane in Treating Postmenopausal Women With Estrogen Receptor-Positive and/or Progesterone Receptor-Positive Metastatic Breast CancerNCT00573755 · 2007-12-01
TERMINATED
Cognitive Function in Older Women With Stage I, Stage II, or Stage III Breast Cancer Receiving Hormone TherapyNCT00681928 · 2007-10-01
COMPLETED
PhII Neo-Adjuvant Letrozole & Lapatinib in Pts w/HER2+ & Hormone Receptor+ Operable Breast CA SPORENCT00499681 · 2007-07-01
TERMINATED
Dehydroepiandrosterone (DHEA) and Letrozole in Treating Patients With Metastatic Breast CancerNCT00516542 · 2007-06-01
TERMINATED
Letrozole In Combination With Lapatinib In Neoadjuvant Treatment Of Early Breast CancerNCT00422903 · 2007-04-01
COMPLETED
Study of Anastrozole, Letrozole, or Exemestane With or Without Tamoxifen in Treating Postmenopausal Women With Hormone-Responsive Breast Cancer That Has Been Completely Removed By SurgeryNCT00541086 · 2007-03-01
UNKNOWN
Letrozole and Goserelin or Leuprolide in Treating Premenopausal Estrogen Receptor-Positive Patients With Stage IV Breast CancerNCT00498901 · 2007-02-01
TERMINATED
Vitamin D Deficiency, Muscle Pain, Joint Pain, and Joint Stiffness in Postmenopausal Women Receiving Letrozole For Stage I-III Breast CancerNCT00416715 · 2006-10-01
COMPLETED
Chemotherapy and Hormone Therapy as First-Line Therapy in Treating Postmenopausal Women With Metastatic or Locally Advanced Breast CancerNCT00403182 · 2006-05-01
WITHDRAWN
Safety and Efficacy of Hormone Therapy With Letrozole in Postmenopausal Women With Breast CancerNCT00330317 · 2006-02-01
COMPLETED
Exemestane, Letrozole, or Anastrozole in Treating Postmenopausal Women Who Are Undergoing Surgery for Stage II or Stage III Breast CancerNCT00265759 · 2006-01-01
COMPLETED
Treatment and Survival Continuation Study of Atamestane Plus Toremifene vs Letrozole in Advanced Breast CancerNCT00267553 · 2005-11-01
TERMINATED
Zoledronate in Preventing Bone Loss in Postmenopausal Women Who Are Receiving Letrozole for Stage I, Stage II, or Stage IIIA Breast CancerNCT00107263 · 2005-01-01
COMPLETED
Letrozole in Breast Cancer Who Have Received 5 Years of Aromatase Inhibitor TherapyNCT00754845 · 2004-11-23
COMPLETED
Bevacizumab and Letrozole in Treating Postmenopausal Women With Locally Advanced or Metastatic Breast Cancer That Cannot Be Removed By SurgeryNCT00305825 · 2004-08-01
COMPLETED
Letrozole With or Without Zoledronate in Treating Healthy Postmenopausal Women With High Breast DensityNCT00114270 · 2004-05-01
COMPLETED
HOBOE: A Phase 3 Study of Adjuvant Triptorelin and Tamoxifen, Letrozole, or Letrozole and Zoledronic Acid in Premenopausal Patients With Breast Cancer.NCT00412022 · 2004-03-01
UNKNOWN
Letrozole and Celecoxib in Treating Postmenopausal Women With Locally Advanced or Metastatic Breast CancerNCT00101062 · 2004-01-01
TERMINATED
Ph II Letrozole + OSI-774 (Tarceva) in Post-menopausal, w/ ER and/or PR-positive Met Breast Cancer.NCT00611715 · 2003-11-01
TERMINATED
Neoadjuvant Letrozole in Treating Postmenopausal Women With Estrogen-Receptor Positive and/or Progesterone-Receptor Positive Stage II, Stage IIIA, or Stage IIIB Breast CancerNCT00084396 · 2003-10-01
COMPLETED

Common conditions

Breast Cancer46Estrogen Receptor-positive Breast Cancer6Recurrent Breast Cancer6Stage IIIA Breast Cancer6HER2-negative Breast Cancer5Progesterone Receptor-positive Breast Cancer5Stage II Breast Cancer5Breast Neoplasms4Stage IIIB Breast Cancer4Stage IIIC Breast Cancer4Stage IV Breast Cancer4Arthralgia2Male Breast Cancer2Neoplasms, Hormone-dependent2Osteoporosis2Pain2Stage I Breast Cancer2Advanced Metastatic Breast Cancer1brca1 Mutation Carrier1brca2 Mutation Carrier1Breast Cancer Invasive Nos1Ductal Carcinoma in Situ1Early Breast Cancer1Endocrine Breast Diseases1Estrogen Receptor Positive Breast Cancer1

Trial status mix

COMPLETED41
TERMINATED15
UNKNOWN7
ACTIVE_NOT_RECRUITING3
WITHDRAWN2

Phase mix

PHASE230
PHASE322
PHASE18
NA3
PHASE43
EARLY_PHASE11

Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.