Intervention

Sertraline

ClinicalTrials.gov intervention label

Clinical trials61

Recruiting5

Common conditions25

Lead sponsors shown15

Clinical trials

60 shown

Sertraline Combined With Multi-Strain Probiotics for Adolescent DepressionNCT07645157 · 2026-10-01

Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment FailureNCT05603104 · 2025-04-27

Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental DisordersNCT06081348 · 2024-09-16

Establishing Multimodal Brain Biomarkers for Treatment Selection in DepressionNCT05892744 · 2023-09-30

NMDA Modulation in Major Depressive DisorderNCT04637620 · 2017-06-01

Switching Medication and Augmentation Strategies for SSRI-Resistant Adolescent Depression（SMART-I)NCT07011693 · 2025-06-20

NOT_YET_RECRUITING

The Research of Ammoxetine Hydrochloride Enteric-coated Tablets in Subjects With DepressionNCT06827431 · 2025-02-14

NOT_YET_RECRUITING

SMART Trial to Predict Anhedonia Response to Antidepressant TreatmentNCT05537584 · 2022-09-30

Non-interventional, Retrospective Cohort Study to Explore Antidepressant Treatment in KoreaNCT04446039 · 2022-07-04

Sertraline Versus Escitalopram in South Asian Participants With Moderate to Severe Major Depressive DisorderNCT05950061 · 2022-06-01

A Comparative Study of Sage-217 Plus an Antidepressant (ADT) Versus Placebo Plus an ADT in Adults With Major Depressive DisorderNCT04476030 · 2020-11-09

Leveraging EEG for Antidepressant Prediction With Sertraline and EscitalopramNCT04388202 · 2020-10-15

Personalized Sertraline Dosing in Patients With DepressionNCT05210153 · 2020-07-16

A Pilot Trial of Perinatal Depression Treatment in HIV Infected WomenNCT04094870 · 2019-10-30

Vortioxetine in the Elderly vs. Selective Serotonin Reuptake Inhibitors (SSRIs): a Pragmatic AssessmentNCT03779789 · 2019-02-01

Brain Hippocampal Volume Relationship With Anxious Symptoms in Major Depressive PatientsNCT04430556 · 2018-07-01

Cryptococcal Antigen Screening Plus SertralineNCT03002012 · 2017-11-15

A Randomized Controlled Trial of Sertraline in Paroxysmal Arterial HypertensionNCT02641652 · 2017-11-01

Safety of Anti-Depressant for Chronic Obstructive Pulmonary Disease (SAD-COPD)NCT02813447 · 2016-08-01

Vortioxetine vs Sertraline in MexicansNCT03978286 · 2016-06-30

NMDA Modulation in Major Depressive Disorder in Late- LifeNCT03414931 · 2016-01-01

The Therapeutic Effect of Transcranial Direct Current Stimulation on Depression in Parkinson's DiseaseNCT02917122 · 2015-08-01

Adjunctive Sertraline for the Treatment of HIV-Associated Cryptococcal MeningitisNCT01802385 · 2015-03-09

Pharmacovigilance in Gerontopsychiatric PatientsNCT02374567 · 2015-01-01

A New Treatment Approach for Major Depressive Disorder Based Upon Targeting Monoamine Oxidase A (MAO-A)NCT02269540 · 2014-10-01

Effect of Lactobacillus Plantarum 299v Supplementation on Major Depression TreatmentNCT02469545 · 2014-06-01

Integral Assessment in Unipolar DepressionNCT02268487 · 2014-01-01

Frontal Hypoperfusion Effects on Antidepressant Outcomes in Late-Life DepressionNCT01896934 · 2013-07-01

Effects of Cerebral Hypoperfusion and Its Reversal on Late-Life DepressionNCT01794455 · 2013-05-01

Riluzole Augmentation Pilot in Depression (RAPID) TrialNCT01703039 · 2013-01-01

Does Vilazodone Help With Antidepressant-associated Sexual Dysfunction?NCT01856127 · 2013-01-01

Late-life Depression and Cerebral PerfusionNCT01751828 · 2012-12-01

Algorithm Guided Treatment Strategies for Major Depressive DisorderNCT01764867 · 2012-06-01

Safety and Tolerability of Oral OPC-34712 as Adjunctive Therapy in Adults With Major Depressive Disorder (the Orion Trial)NCT01360866 · 2011-10-01

Optimizing Antidepressant Treatment by Genotype-dependent Adjustment of Medication According to the ABCB1 GeneNCT02237937 · 2011-09-01

The Effects of Sertraline on Depression in Parkinson's DiseaseNCT01437189 · 2011-08-01

Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care for DepressionNCT01407094 · 2011-07-29

The Effect of Problem Solving Therapy and Antidepressant Therapy on Cerebral Perfusion and Brain Derived Neurotropic Factor (BDNF) in Depressed EldersNCT01305889 · 2011-03-01

Strategic Use of New Generation Antidepressants for DepressionNCT01109693 · 2010-12-01

A Pharmacokinetic Study of the Coadministration of LY2216684 With SertralineNCT01250873 · 2010-11-01

Rhodiola Rosea Therapy of Major Depressive DisorderNCT01098318 · 2010-06-01

Efficacy Study of Transcranial Direct Current Stimulation to Treat Major Depressive DisorderNCT01033084 · 2009-12-01

fMRI Study of Treatment Changes in Major DepressionNCT01027559 · 2009-02-01

International Study to Predict Optimised Treatment - in DepressionNCT00693849 · 2008-09-01

Seroquel Alone Versus Seroquel With an SSRI for Depression With Psychotic SymptomsNCT00955474 · 2008-09-01

Postpartum Depression: Transdermal Estradiol Versus SertralineNCT00744328 · 2008-08-01

Analisis of Facors Involved in Antidepressant Treatment Response of Major Depressive DisorderNCT01454635 · 2008-06-01

Adding an Insulin-Sensitizing Medication to Depression Treatment for People Who Are Depressed and OverweightNCT00834652 · 2007-09-01

Study for Evaluating Different Methods of Measuring Depression Treatment ResponseNCT00406952 · 2006-11-01

Efficacy of Seroquel SR in Combination With an Antidepressant in Treatment of Major Depressive DisorderNCT00351910 · 2006-05-01

A Research Study to Compare the Treatments of a Combination of Elzasonan With Zoloft, to Zoloft Alone, or Placebo in People With Major Depressive Disorder (MDD)NCT00275197 · 2005-12-01

Study Of Indiplon/Placebo With Sertraline In Insomnia Co-Existing With DepressionNCT00232167 · 2005-11-01

Multicentre Trial to Evaluate the Safety and Efficacy of CP-316,311 in Major Depressive DisorderNCT00143091 · 2005-04-01

Magnetic Resonance Imaging Study of Geriatric DepressionNCT00245557 · 2004-11-01

Antidepressant Medication Treatment for Depression in Individuals With Chronic Heart FailureNCT00078286 · 2003-11-01

Ziprasidone vs. Sertraline/Haloperidol in Psychotic DepressionNCT00340379 · 2003-04-01

Study of Pharmacotherapy of Psychotic DepressionNCT00056472 · 2003-01-01

Sertraline in Generalized Social Phobia With Co-Occurring Anxiety and Mood DisordersNCT00182533 · 2002-07-01

Treatments for Depression: Drug Versus PsychotherapyNCT00043550 · 2001-11-01

Treatment of Major Depression With St. John's Wort (Hypericum)NCT00005013 · 1998-12-01

Common conditions

Leading sponsors

Pfizer4 Duke University3 Vanderbilt University3 Mclean Hospital2 University of Minnesota2 University of Pennsylvania2 University of Sao Paulo2 Washington University School of Medicine2 Alto Neuroscience1 AstraZeneca1 Azienda Ospedaliera Universitaria Integrata Verona1 Biogen1 BRC Operations Pty. Ltd.1 Brigham and Women's Hospital1 Centre for Addiction and Mental Health1

Trial status mix

COMPLETED33

TERMINATED12

UNKNOWN6

RECRUITING5

WITHDRAWN3

NOT_YET_RECRUITING2

Phase mix

PHASE421

PHASE316

PHASE213

NA10

PHASE12

EARLY_PHASE11

Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.