Intervention

Methotrexate

ClinicalTrials.gov intervention label

How to interpret these research links

Connected source records

This is the original ClinicalTrials.gov intervention label, found in 205 distinct published trials. Registry interventions may represent drugs, devices, procedures or other study activities. A matched term or study association does not establish product equivalence, efficacy or regulatory approval.

Data basis: current published ClinicalTrials.gov records and, where present, RxNorm, MONDO and FDA-label identifiers. See the evidence interpretation and counting methodology.

Clinical trials205

Recruiting10

Common conditions25

Lead sponsors shown15

Clinical trials

60 shown

Complementary Herbal Approach to Rheumatoid Management Study (CHARMS)NCT07627893 · 2026-06-01

Immunosuppressant Management in Rheumatology Patients Undergoing Elective Total Shoulder ArthroplastyNCT07138898 · 2025-12-12

Efficacy and Safety of Resveratrol in Patients With Rheumatoid Arthritis.NCT07089381 · 2025-08-01

Pentoxifylline as Anti-Inflammatory in Patients With Rheumatoid ArthritisNCT06998628 · 2025-06-02

Methotrexate Combined With Tofacitinib in Rheumatoid ArthritisNCT06301373 · 2024-09-01

MethMax Trial: MAXimising the METHotrexate Therapy Potential in Patients With Active Rheumatoid ArthritisNCT06649136 · 2024-08-12

BRE-08 Phase II Study of CMC Regimen for Early Stage Breast CancerNCT06085742 · 2023-11-22

The Clinical Efficacy of Immunomodulators in RA PatientsNCT05626348 · 2021-12-22

STep-up and Step-down Therapeutic Strategies in Childhood ARthritiSNCT03728478 · 2019-05-29

Treatment of Rheumatoid Arthritis With DMARDs: Predictors of ResponseNCT03414502 · 2007-12-10

Treatment Strategy for Patients With RA-ILDNCT07643038 · 2026-09-20

NOT_YET_RECRUITING

A Clinical Study of Tulisokibart (MK-7240) to Treat Rheumatoid Arthritis (RA) (MK-7240-014)NCT07176390 · 2025-10-08

ACTIVE_NOT_RECRUITING

Effect of MTX Discontinuation on Shingrix Response in RANCT06574594 · 2024-08-22

Paroxetine Safety and Efficacy in Rheumatoid ArthritisNCT06231745 · 2024-01-31

Premedication to Reduce Amivantamab Associated Infusion Related ReactionsNCT05663866 · 2023-05-18

ACTIVE_NOT_RECRUITING

Modified Zhiwang Decoction Combined With Methotrexate in the Treatment of Early Rheumatoid ArthritisNCT05508815 · 2023-02-09

MAD Study of IA-14069NCT05533372 · 2022-10-10

Cilostazol and Methotrexate in Rheumatoid ArthritisNCT05594680 · 2022-10-01

Methotrexate in Patients with Early Rheumatoid ArthritisNCT05353829 · 2022-04-28

ACTIVE_NOT_RECRUITING

ATI-450 Plus Methotrexate (MTX) Versus Placebo Plus MTX in Participants With Moderate to Severe Active Rheumatoid Arthritis (RA)NCT05279417 · 2022-02-01

Low-dose Methotrexate for Change in Global Initiative for Asthma Step 5 Medications in Chronic Severe AsthmaNCT02124226 · 2021-12-01

A Study to Compare the Response to Treatment With Abatacept vs Adalimumab, on Background Methotrexate, in Adults With Early, Seropositive, and Shared Epitope-positive Rheumatoid Arthritis and an Inadequate Response to MethotrexateNCT04909801 · 2021-09-15

ACTIVE_NOT_RECRUITING

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Methotrexate vs HydroxychloroquineNCT04691505 · 2020-12-23

Effects of Tofacitinib vs Methotrexate on Rheumatoid Arthritis Interstitial Lung DiseaseNCT04311567 · 2020-11-07

A Study of Comparing Rates of Dementia and Alzheimer's Disease in Participants Initiating Methotrexate Versus Those Initiating Anti-tumor Necrosis Factor (TNF)-Alpha TherapyNCT04571697 · 2020-09-28

Study of ATI-450 Plus Methotrexate (MTX) vs MTX Alone in Patients With Moderate to Severe RANCT04247815 · 2020-03-16

Tripterygium Wilfordii Hook F and Methotrexate for Postmenopausal Women With Rheumatoid ArthritisNCT04136262 · 2019-11-25

Efficacy of Chinese Herbal Medicine Qing Re Huo Xue in Patients With Rheumatoid ArthritisNCT04170504 · 2019-11-14

Efficacy and Safety Study of KN019 in Rheumatoid Arthritis Patients With an Inadequate Response to MethotrexateNCT04038970 · 2019-11-08

Tofacitinib Versus Methotrexate as the First Line DMARD in the Treatment of Rheumatoid ArthritisNCT04464642 · 2019-07-10

Study of Two Doses of ABX464 in Participants With Moderate to Severe Rheumatoid ArthritisNCT03813199 · 2019-07-04

Effectiveness and Safety of Yisaipu Combined With Tripterygium Wilfordii for Active RANCT03589833 · 2019-05-14

Targeted Treatment Early With Etanercept + Methotrexate vs.T2T Care for DMARD-naïve Early RA Patients Based on naïve T-cell StratificationNCT03813771 · 2019-03-01

Breast Cancer Treatment Based on Organ-like CultureNCT03925233 · 2019-01-02

Regorafenib and Methotrexate in Treating Participants With Recurrent or Metastatic KRAS Mutated Non-Small Cell Lung CancerNCT03520842 · 2018-08-14

Rheumatoid Arthritis Response to MethotrexateNCT03535519 · 2018-08-07

Juanbi Pill for Rheumatoid ArthritisNCT02885597 · 2018-07-01

Molecular Profile of Breast Cancer in Ugandan Patients With Stage IIB-III Breast CancerNCT03518242 · 2018-06-06

Abatacept to Silence Anti-citrullinated Protein Antibody-expressing B Cells in Rheumatoid Arthritis (ASCARA)NCT03492658 · 2018-05-17

Evaluation of the Optimal MTX Dose as an Add-on Therapy to Adalimumab for RA Patients in Japan, South Korea and TaiwanNCT03505008 · 2018-04-18

Effect of Sarilumab on Patient-reported Outcomes in Patients With Active Rheumatoid ArthritisNCT03449758 · 2018-03-05

Study Evaluating Gerilimzumab´s Safety/Efficacy for Patients MTX or TNFα Antagonist Failed in Rheumatoid ArthritisNCT02795299 · 2018-01-01

Add-on Methotrexate for the Treatment of SchizophreniaNCT03369795 · 2017-12-15

A Study of the EP4 Antagonist CR6086 in Combination With Methotrexate, in DMARD-naïve Patients With Early Rheumatoid ArthritisNCT03163966 · 2017-10-05

Methotrexate, Blood Pressure and Arterial Function in Rheumatoid ArthritisNCT03254589 · 2017-10-01

Effects of Concomitant Administration of BMS-986195 on Methotrexate, Caffeine, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and PravastatinNCT03131973 · 2017-05-13

Evaluation of Pharmacokinetics and Safety of GSK3196165 in Combination With Methotrexate in Japanese Subjects With Rheumatoid ArthritisNCT03028467 · 2017-01-24

Clinical Trial Evaluating Metronomic Chemotherapy in Patients With Metastatic OsteosarcomaNCT03063983 · 2017-01-02

A Study of RO7123520 to Evaluate the Safety and Efficacy in Participants With Moderately To Severely Active Rheumatoid Arthritis (RA) Who Are Inadequately Responding to Anti-Tumor Necrosis Factor (TNF)-Alpha TherapyNCT03001219 · 2016-12-22

Andecaliximab as Add-On Therapy to a Tumor Necrosis Factor Inhibitor and Methotrexate Regimen in Adults With Moderately to Severely Active Rheumatoid ArthritisNCT02862574 · 2016-12-15

Safety, Tolerability, and Efficacy of GS-9876 in Participants With Active Rheumatoid Arthritis on Background Therapy With MethotrexateNCT02885181 · 2016-09-21

A Study to Evaluate the Efficacy and Safety of ASP1707 in Postmenopausal Female Patients With Rheumatoid Arthritis Taking MethotrexateNCT02884635 · 2016-09-16

Methotrexate Withdrawal Study of Tofacitinib Modified Release Formulation in Subjects With Rheumatoid ArthritisNCT02831855 · 2016-09-01

Comparison of Disease Modifying Antirheumatic Drugs Therapy in Patients With RA Failing Methotrexate MonotherapyNCT02930343 · 2016-09-01

2-week dc of MTX and Influenza Vaccination in RANCT02897011 · 2016-09-01

A Phase 3 Study of Abatacept in Chinese Patients With Active Rheumatoid Arthritis and Inadequate Response to MethotrexateNCT02722694 · 2016-08-01

Treatments Against RA and Effect on FDG-PET/CTNCT02374021 · 2016-07-01

A Study Comparing Upadacitinib (ABT-494) Monotherapy to Methotrexate (MTX) Monotherapy in Adults With Rheumatoid Arthritis (RA) Who Have an Inadequate Response to MTX (SELECT-MONOTHERAPY)NCT02706951 · 2016-03-23

Transarterial Chemoperfusion: Cisplatin, Methotrexate, Gemcitabine for Unresectable Pleural MesotheliomaNCT02611037 · 2016-03-04

A Study to Compare Upadacitinib (ABT-494) Monotherapy to Methotrexate (MTX) Monotherapy in Adults With Rheumatoid Arthritis (RA) Who Have Not Previously Taken MethotrexateNCT02706873 · 2016-02-23

Common conditions

Leading sponsors

Hoffmann-La Roche 26 Bristol-Myers Squibb 10 Genentech, Inc. 7 Merck Sharp & Dohme LLC 6 Eli Lilly and Company 5 National Institute of Allergy and Infectious Diseases (NIAID) 5 Pfizer 5 Sanofi 5 Amgen 4 Astellas Pharma Inc 4 Janssen Research & Development, LLC 4 Takeda 4 University of Leeds 4 AbbVie (prior sponsor, Abbott) 3 Brigham and Women's Hospital 3

Trial status mix

COMPLETED144

TERMINATED24

UNKNOWN19

RECRUITING10

ACTIVE_NOT_RECRUITING5

WITHDRAWN2

NOT_YET_RECRUITING1

Phase mix

PHASE376

PHASE262

PHASE444

PHASE117

NA9

EARLY_PHASE11

Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.