Intervention

Methotrexate (MTX)

ClinicalTrials.gov intervention label

How to interpret these research links

Connected source records

This is the original ClinicalTrials.gov intervention label, found in 16 distinct published trials. Registry interventions may represent drugs, devices, procedures or other study activities. A matched term or study association does not establish product equivalence, efficacy or regulatory approval.

Data basis: current published ClinicalTrials.gov records and, where present, RxNorm, MONDO and FDA-label identifiers. See the evidence interpretation and counting methodology.

Clinical trials16

Recruiting1

Common conditions7

Lead sponsors shown14

Clinical trials

16 shown

Changes in MTX-PG Concentrations During Subcutaneous MTX Therapy in Patients With Rheumatoid Arthritis(COSMOS Study)NCT06913907 · 2025-04-10

Natrunix in Combination With Methotrexate for Rheumatoid Arthritis TreatmentNCT06590090 · 2026-07-15

NOT_YET_RECRUITING

Ultrasound as Imaging Biomarker of Early Response to Tocilizumab and Methotrexate in Very Early Rheumatoid ArthritisNCT02837146 · 2015-12-01

A Study of the Impact of Methotrexate (MTX) Discontinuation on the Efficacy of Subcutaneous (SC) Tocilizumab (TCZ) With MTXNCT01855789 · 2013-11-07

An Efficacy And Safety Study of CNTO 6785 In Participants With Active Rheumatoid Arthritis Despite Methotrexate TherapyNCT01909427 · 2013-06-01

Study to Assess the Short- and Long-term Efficacy of Certolizumab Pegol Plus Methotrexate Compared to Adalimumab Plus Methotrexate in Subjects With Moderate to Severe Rheumatoid Arthritis (RA) Inadequately Responding to MethotrexateNCT01500278 · 2011-12-01

Methotrexate (Rheumatrex) High Dose Special Investigation (Regulatory Post Marketing Commitment Plan)NCT01414257 · 2011-05-01

Exposure Study Comparing 3 Routes of Methotrexate (MTX) AdministrationNCT01737944 · 2011-01-01

Study of Subcutaneous Golimumab in Chinese Patients With Active Rheumatoid Arthritis Despite Methotrexate TherapyNCT01248780 · 2010-09-01

A Study of CH-4051 in Patients With Rheumatoid Arthritis (RA)NCT01116141 · 2010-09-01

Golimumab in Rheumatoid Arthritis Participants With an Inadequate Response to Etanercept (ENBREL) or Adalimumab (HUMIRA)NCT01004432 · 2009-12-01

A Safety and Efficacy Study of Golimumab (CNTO 148) in Patients With Active Rheumatoid Arthritis Despite Methotrexate TherapyNCT00727987 · 2008-05-01

A Study to Assess CH1504 in Patients With Active Rheumatoid ArthritisNCT00658047 · 2008-04-01

Phase IIIB Subcutaneous Abatacept Monotherapy StudyNCT00547521 · 2007-12-01

Safety and Efficacy of Intravenous ACZ885 and Oral Methotrexate Therapy in Patients With Early Rheumatoid ArthritisNCT00487825 · 2007-03-01

Co-Administration Of Methotrexate And CP-690,550NCT01745055 · 2005-04-01

Common conditions

Rheumatoid Arthritis11 Arthritis2 Arthritis, Rheumatoid2 Rheumatoid Arthritis (RA)2 Autoimmune Diseases1 High Dose1 Rheumatoid1

Leading sponsors

Chelsea Therapeutics 2 Pfizer 2 Antares Pharma Inc. 1 Bristol-Myers Squibb 1 Centocor, Inc. 1 Hoffmann-La Roche 1 Janssen Biotech, Inc. 1 Janssen Pharmaceutical K.K. 1 Janssen Research & Development, LLC 1 Keio University 1 Maria Stoenoiu 1 Novartis 1 UCB Pharma SA 1 XBiotech, Inc. 1

Trial status mix

COMPLETED13

NOT_YET_RECRUITING1

RECRUITING1

UNKNOWN1

Phase mix

PHASE26

PHASE36

PHASE12

PHASE42

Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.