Intervention
Simvastatin
ClinicalTrials.gov intervention label
How to interpret these research links
Connected source recordsThis is the original ClinicalTrials.gov intervention label, found in 82 distinct published trials. Registry interventions may represent drugs, devices, procedures or other study activities. A matched term or study association does not establish product equivalence, efficacy or regulatory approval.
Data basis: current published ClinicalTrials.gov records and, where present, RxNorm, MONDO and FDA-label identifiers. See the evidence interpretation and counting methodology.
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Clinical trials
60 shownLetrozole With and Without Simvastatin for the Treatment of Stage I-III Hormone Receptor Positive, HER2 Negative Breast CancerNCT05464810 · 2022-09-02
RECRUITINGA Study to Investigate the Effect of AZD5004 on Rosuvastatin, Atorvastatin, Simvastatin, Repaglinide and the Effect of Erythromycin on AZD5004 in Healthy ParticipantsNCT06948747 · 2025-05-06
COMPLETEDA Drug-Drug Interaction Study of Orforglipron (LY3502970) in Healthy Overweight and Obese ParticipantsNCT06186622 · 2024-01-02
COMPLETEDCombined Simvastatin and Irinotecan in Treating ES-SCLC Patients Relapsed From 1st ChemotherapyNCT04985201 · 2021-11-01
UNKNOWNCombined Simvastatin and Albumin Paclitaxel in Treating ES-SCLC Patients Relapsed From 1st ChemotherapyNCT04698941 · 2021-07-25
UNKNOWNThe Role of Bisphosphonate and Simvastatin Combination on Therapeutic Response in Breast Cancer With Bone Metastasis Via Dicckopf-1 PathwayNCT07823751 · 2021-04-10
COMPLETEDSimvastatin in Secondary Progressive Multiple SclerosisNCT03896217 · 2019-05-16
COMPLETEDPharmacokinetics of Simvastatin Post Laparoscopic Sleeve Gastrectomy (LSG)NCT03571802 · 2018-06-13
UNKNOWNMultiple Sclerosis-Simvastatin Trial 2NCT03387670 · 2018-03-28
COMPLETEDThe Effect of Simvastatin on Breast Cancer Cell Growth in Women With Stage I-II Breast CancerNCT03454529 · 2018-03-09
COMPLETEDThe Effect of Simvastatin Combined With Ezetimibe in Patients With Stable Angina and DiabetesNCT03771053 · 2018-01-01
UNKNOWNEvaluation Of The Portal Pressure By Doppler Ultrasound In Cirrhotic Patients Before And After SimvastatinNCT02994485 · 2016-10-01
COMPLETEDSimvastatin as a Neuroprotective Treatment for Moderate Parkinson's DiseaseNCT02787590 · 2016-03-08
COMPLETEDThe DDI Study of SP2086 and SimvastatinNCT02817243 · 2016-03-01
UNKNOWNEvaluate the Pharmacokinetics of Simvastatin When Coadministered With PEX168 in Healthy Adult SubjectsNCT02447601 · 2015-03-30
COMPLETEDFixed Dose Intervention Trial of New England Enhancing Survival in SMI PatientsNCT02188121 · 2015-02-01
COMPLETEDLiving With Statins - The Impact of Cholesterol Lowering Drugs on Health, Lifestyle and Well-beingNCT02255682 · 2015-01-01
COMPLETEDStudy to Assess the Effect of AZD9291 on the Blood Levels of Simvastatin in Patients With EGFRm+ NSCLCNCT02197234 · 2014-12-22
COMPLETEDEarly Rheumatoid Arthritis COR InterventionNCT02246257 · 2014-09-01
UNKNOWNDetection and Prevention of Anthracycline-Related Cardiac Toxicity With Concurrent SimvastatinNCT02096588 · 2014-05-20
TERMINATEDSafety of Simvastatin in LAM and TSCNCT02061397 · 2014-03-01
COMPLETEDSimvastatin and Fenofibrate vs Simvastatin Alone in Patients With Type 2 Diabetes Mellitus and Acute Coronary SyndromeNCT02015988 · 2014-01-01
UNKNOWNTrial of Simvastatin for the Treatment of Severe AsthmaNCT02433535 · 2013-12-01
WITHDRAWNSimvastatin Addition for Patients With Recent-onset SchizophreniaNCT01999309 · 2013-10-01
COMPLETEDThe Drug-drug Interaction of SP2086 and SimvastatinNCT02815722 · 2013-07-01
COMPLETEDAssess the Pharmacokinetics of Rosuvastatin and Simvastatin When Administered Alone or in Combination With FostamatinibNCT01725230 · 2012-11-01
COMPLETEDA Study of the Efficacy and Safety of MK-0431D (a Fixed-dose Combination of Sitagliptin and Simvastatin) for the Treatment of Participants With Type 2 Diabetes Mellitus (T2DM) With Inadequate Glycemic Control on Metformin Monotherapy (MK-0431D-266)NCT01678820 · 2012-10-10
TERMINATEDStudy of Metformin With Simvastatin for Men With Prostate CarcinomaNCT01561482 · 2012-01-01
WITHDRAWNA Study To Estimate The Effect Of Repeated Dosing of PF-05175157 On The Pharmacokinetics Of A Single Dose Of Simvastatin In Healthy Adult SubjectsNCT01469468 · 2011-11-01
COMPLETEDEndothelial Facilitation in Alzheimer's DiseaseNCT01439555 · 2011-11-01
COMPLETEDStudy About Simvastatin in Portal Hypertension in Compensated CirrhosisNCT01282398 · 2011-04-01
UNKNOWNHemodynamic Effect of Simvastatin With Beta Blockers in Clinical Portal HypertensionNCT01282385 · 2011-04-01
UNKNOWNThe Additive Anti-inflammatory Effect of Simvastatin in Combination With Inhaled Corticosteroids on p38 MAPK in AsthmaNCT01266434 · 2011-01-01
COMPLETEDEfficacy of Statin Association With Standard Treatment in Prevention of Recurrent Hemorrhage in Patient With Cirrhosis and Variceal BleedingNCT01095185 · 2010-11-01
COMPLETEDRandomized Double Blind Placebo Control Study in Patients with SchizophreniaNCT01602029 · 2010-08-01
COMPLETEDSimvastatin Effect on Portal HypertensionNCT02134626 · 2010-08-01
COMPLETEDEffects of Simvastatin on BiomarkersNCT01142336 · 2010-06-01
COMPLETEDThe Effect of Statins in Patients With Chronic Obstructive Pulmonary Disease (COPD)NCT01151306 · 2010-06-01
COMPLETEDA Drug Interaction Study Between Simvastatin, Atorvastatin, Rosuvastatin, and GSK2248761 in Healthy Subjects.NCT01138072 · 2010-06-01
COMPLETEDA Study to Investigate the Interaction of GSK1292263 With Rosuvastatin and Simvastatin in Healthy SubjectsNCT01101568 · 2010-04-14
COMPLETEDTargeting Microvascular Dysfunction in Young Hypertensive PatientsNCT01047423 · 2009-08-01
WITHDRAWNRole of Anti-Inflammatory Agents in Patients With SchizophreniaNCT00929955 · 2009-06-01
COMPLETEDEfficacy of Simvastatin for the Treatment of COPDNCT02070133 · 2009-05-01
COMPLETEDStatin Effects on Beta-Amyloid and Cerebral Perfusion in Adults at Risk for Alzheimer's DiseaseNCT00939822 · 2009-03-01
COMPLETEDTargeting Sympathetic Overactivity in Heart Failure Patients With StatinsNCT01097785 · 2009-03-01
COMPLETEDComparison of Optimal Antipsychotic Treatments for Adults With SchizophreniaNCT00802100 · 2008-12-01
COMPLETEDMetabolic and Vascular Effects of Statins in Untreated Dyslipidemic Diabetic PatientsNCT00854503 · 2008-09-01
COMPLETEDSimvastatin in Chronic Obstructive Pulmonary Disease (COPD)NCT00680641 · 2008-04-01
UNKNOWNCardio Risk of Acute Schizophrenia Olanzapine DukeNCT00672464 · 2008-04-01
WITHDRAWNSimvastatin as an add-on Treatment to Copaxone for the Treatment of Relapsing Multiple SclerosisNCT00429442 · 2008-03-01
WITHDRAWNPhase II Study of Simvastatin in Primary Breast Cancer; Test of Its Potential Selectivity on Basal Subtype Breast CancerNCT00807950 · 2008-03-01
UNKNOWNAdd-on Simvastatin in Schizophrenia TrialNCT00605995 · 2008-02-01
TERMINATEDInvestigation of Simvastatin in Secondary Progressive Multiple SclerosisNCT00647348 · 2008-01-01
COMPLETEDStatin Therapy Versus Placebo Prior to ProstatectomyNCT00572468 · 2007-12-01
COMPLETEDA Study To Evaluate The Safety And Tolerability Of SB-656933-AAA Following Repeated Doses In Healthy Adult SubjectsNCT00504439 · 2007-06-04
COMPLETEDClinical Trial of Zocor (Simvastatin) and Vytorin (Ezetimibe/Simvastatin) in Adolescents With Type 1 DiabetesNCT00477204 · 2007-05-01
COMPLETEDSimvastatin and Diastolic DysfunctionNCT01061450 · 2006-11-01
COMPLETEDA Study for Pre-diabetic Patients With Cholesterol Lowering DrugsNCT00831129 · 2006-09-01
COMPLETEDA Study of Aspirin and Simvastatin in Pulmonary Arterial HypertensionNCT00384865 · 2006-09-01
TERMINATEDA Drug-Drug Interaction Study of GK Activator (2) and Simvastatin in Patients With Type 2 Diabetes.NCT00377442 · 2006-08-01
COMPLETEDCommon conditions
Schizophrenia7Schizoaffective Disorder5Type 2 Diabetes4Alzheimer's Disease3Breast Cancer3Cardiovascular Disease3Dyslipidemia3Hypertension3Liver Cirrhosis3Portal Hypertension3Rheumatoid Arthritis3Schizophreniform Disorder3Small Cell Lung Cancer3Type 2 Diabetes Mellitus3Alzheimer Disease2Chronic Obstructive Pulmonary Disease2Cirrhosis2Coronary Heart Disease2Diabetes2Diabetes Mellitus2Diabetes Mellitus, Type 22Heart Failure2HIV Infections2Hypercholesterolemia2Invasive Breast Carcinoma2
Leading sponsors
AstraZeneca
3
GlaxoSmithKline
3
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
2
Hoffmann-La Roche
2
Imperial College London
2
Jiangsu HengRui Medicine Co., Ltd.
2
National Institute of Allergy and Infectious Diseases (NIAID)
2
National University Hospital, Singapore
2
Pakistan Institute of Living and Learning
2
Shanghai Pulmonary Hospital, Shanghai, China
2
University College, London
2
University of California, Davis
2
University of Pennsylvania
2
University of Wisconsin, Madison
2
Alabama Neurology Associates, PC
1
Trial status mix
COMPLETED60
UNKNOWN12
WITHDRAWN5
TERMINATED4
RECRUITING1
Phase mix
PHASE224
PHASE118
PHASE418
PHASE314
NA9
EARLY_PHASE12
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Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.