Sponsor

Mannkind Corporation

Clinical research sponsor

Published trials49
Recruiting shown3
Roles2
SourceClinicalTrials.gov

Clinical trials

49 shown
INHALE-1st: Afrezza® For Youth With Newly-Diagnosed Type 1 DiabetesNCT07224321 · lead sponsor · 2026-02-04
RECRUITING
INHALE-3: Afrezza® Combined With Insulin Degludec Versus Usual Care in Adults With Type 1 DiabetesNCT05904743 · lead sponsor · 2023-07-07
COMPLETED
Afrezza With Basal Combination (ABC): Afrezza® Combined With AID Pump or Insulin Degludec in Adults With Type 1 DiabetesNCT05243628 · lead sponsor · 2022-03-31
COMPLETED
Afrezza® INHALE-1 Study in PediatricsNCT04974528 · lead sponsor · 2021-09-29
COMPLETED
Afrezza® Dosing Optimization StudyNCT04849845 · lead sponsor · 2021-04-09
COMPLETED
Pharmacokinetics, Safety and Tolerability of Treprostinil Inhalation Powder in Healthy Normal VolunteersNCT03464864 · lead sponsor · 2018-03-09
COMPLETED
Afrezza Safety and Pharmacokinetics Study in Pediatric PatientsNCT02527265 · lead sponsor · 2017-09-28
COMPLETED
PK and PD Within-Subject Variability of a Single Dose of Afrezza Inhaled Technosphere Insulin in Patients With Diabetes Mellitus Type 1 (T1DM)NCT02485327 · lead sponsor · 2015-07-01
COMPLETED
Single Dose Clamp Study to Evaluate Concentration-time Profile and Metabolic Activity of 3 Dose Levels of Afrezza and 3 Dose Levels of Insulin Lispro in Patients With Type 1 Diabetes MellitusNCT02470637 · lead sponsor · 2015-06-01
COMPLETED
Comparison of Technosphere Insulin Inhalation Powder & Subcutaneous Rapid-Acting Analog in Subjects With Type 1 DiabetesNCT01544881 · lead sponsor · 2012-03-01
COMPLETED
Comparison of Technosphere® Insulin Versus Technosphere Powder (Placebo) in Insulin-Naive Subjects With Type 2 Diabetes MellitusNCT01451398 · lead sponsor · 2011-11-01
COMPLETED
Clinical Trial Evaluating Technosphere® Insulin Versus Insulin Aspart in Subjects With Type 1 Diabetes Mellitus Over a 24-week Treatment PeriodNCT01445951 · lead sponsor · 2011-09-01
COMPLETED
Pulmonary Function Substudy for Subjects Enrolled in Studies MKC-TI-161, MKC-TI-162 or MKC-TI-166NCT01201928 · lead sponsor · 2010-10-01
TERMINATED
Clinical Trial Evaluating the Efficacy and Safety of Technosphere® Inhalation Insulin (TI) Inhalation Powder Using the Gen2 InhalerNCT01196104 · lead sponsor · 2010-09-01
TERMINATED
Evaluate Safety of Technosphere® Insulin (TI) in Diabetic Subjects With Moderate Obstructive Pulmonary DiseaseNCT00642616 · lead sponsor · 2009-03-01
TERMINATED
Patient Transitioning From Exubera® Inhalation Powder to Technosphere® Insulin Inhalation PowderNCT01798914 · lead sponsor · 2008-10-01
NO_LONGER_AVAILABLE
Safety and Efficacy of Technosphere® Insulin Inhalation Powder (TI Inhalation Powder)When an Optimal Dose is Taken With Varied Carbohydrate IntakeNCT00747006 · lead sponsor · 2008-09-01
TERMINATED
A Study Designed to Determine if the Pharmacokinetic Disposition of Inhaled Insulin Exposure is the Same for Asthmatics and Non-asthmaticsNCT00673621 · lead sponsor · 2008-05-01
COMPLETED
A Study Designed to Determine if the Drugs Albuterol (Salbutamol) and Fluticasone Have an Effect on the Pharmacokinetics of the Investigational Product Technosphere® Insulin Inhalation Powder in Healthy VolunteersNCT00674050 · lead sponsor · 2008-05-01
COMPLETED
Safety and Efficacy of Technosphere® Insulin Inhalation Powder and Lantus® Compared to Humalog® and Lantus® Over 16-WeeksNCT00700622 · lead sponsor · 2008-05-01
TERMINATED
A Study Designed to Compare 2 Dose Strengths of TI Inhalation Powder in Adults With Type 1 Diabetes Mellitus and to Compare One of Those Formulations (30Units) With an Injection of Insulin LisproNCT00662857 · lead sponsor · 2008-04-01
COMPLETED
A Study Designed to Determine the Safety and Pharmacological Response ofMKC253 Inhalation Powder in Adults With Type 2 Diabetes MellitusNCT00642538 · lead sponsor · 2008-02-01
COMPLETED
Effects of URI on Diabetic Subjects Utilizing Technosphere Insulin After a Meal ChallengeNCT00642681 · lead sponsor · 2007-12-01
COMPLETED
A Study Comparing Subcutaneous Rapid Acting Insulin and One Formulation of Inhaled Insulin in Subjects With Type 2 DiabetesNCT00570687 · lead sponsor · 2007-09-01
COMPLETED
Single Dose, Single Administration Study of Technosphere Inhalation Powder in Diabetic Subjects With Mild or Moderate Kidney Disease Compared to Diabetic Subjects With Normal Kidney FunctionNCT00626249 · lead sponsor · 2007-08-01
COMPLETED
A 2-Month Safety Follow-Up TrialNCT00741429 · lead sponsor · 2007-05-01
COMPLETED
A First in Human, Single Dose, Safety and Tolerability Study of MKC253 Inhalation Powder in Healthy Adult MalesNCT00475371 · lead sponsor · 2007-04-01
COMPLETED
Safety and Immune Response to a Multi-component Immune Based Therapy (MKC1106-PP) for Patients With Advanced Cancer.NCT00423254 · lead sponsor · 2007-02-01
COMPLETED
A Study to Evaluate Insulin in the Blood After Inhalation of a Dry Powder Insulin Formulation (Called Technosphere®/Insulin) in Non-diabetic Patients With & Without Chronic Obstructive Pulmonary Disease (COPD)NCT01021891 · lead sponsor · 2006-07-01
COMPLETED
Inhaled Technosphere Insulin in Subjects With Diabetes Mellitus and AsthmaNCT00332826 · lead sponsor · 2006-06-01
TERMINATED
Efficacy and Safety in Subjects With Type 2 Diabetes Receiving Subcutaneous Basal Insulin and Prandial Inhalation of Technosphere/Insulin Versus Subcutaneous Premixed Insulin Therapy Over a 52-Week Treatment Period and a 4-Week Follow-upNCT00309244 · lead sponsor · 2006-02-01
COMPLETED
Efficacy & Safety of Inhaled Insulin in Type 1 DiabetesNCT00308308 · lead sponsor · 2006-02-01
COMPLETED
Comparison Between Technosphere/Insulin Inhalation Powder Versus Rapid Acting Insulin in Subjects With Type 2 Diabetes MellitusNCT00539890 · lead sponsor · 2005-11-01
COMPLETED
Safety of Inhaled Insulin With Type 1 and Type 2 DiabetesNCT00308737 · lead sponsor · 2005-06-01
COMPLETED
A 3 Month, Randomized, Open Label, Multi-center Study of Technosphere/Insulin Compared to Insulin Aspart in Subjects With Type 1 Diabetes Mellitus Receiving Insulin GlargineNCT00539396 · lead sponsor · 2005-03-01
COMPLETED
Efficacy and Safety of Prandial Inhalation of Technosphere/Insulin in Combination With Metformin or Technosphere/Insulin Alone Versus 2 Oral Anti-Diabetic Agents in Subjects With Type 2 DiabetesNCT00332488 · lead sponsor · 2004-12-01
COMPLETED
Clamp Study Comparing Inhalation of Technosphere®/Insulin in Smokers and Non-Smokers With Type 2 DiabetesNCT00934414 · lead sponsor · 2004-08-01
COMPLETED
18-Week, Randomized, Double-blind, Placebo Controlled, Forced Titration Study of Patients With Type 2 DiabetesNCT00511732 · lead sponsor · 2004-06-01
COMPLETED
An Open-label, Multi-center, International, Three-year, Safety and Tolerability 'Follow on' TrialNCT00754624 · lead sponsor · 2004-05-01
COMPLETED
Bioavailability of Technosphere® Insulin Versus Subcutaneous Regular Human Insulin in Type 2 DiabetesNCT00511719 · lead sponsor · 2004-02-01
COMPLETED
Study of the Efficacy and Safety of Inhaled Technosphere Insulin in Patients With Type 2 DiabetesNCT00511602 · lead sponsor · 2003-12-01
COMPLETED
To Compare the Effect of Inhaled Insulin With Subcutaneously Injected Insulin in Subjects With Type 2 Diabetes Mellitus.NCT00419302 · lead sponsor · 2003-10-01
COMPLETED
Effect of Inhaled Technosphere Insulin vs RAA Insulin on Exercise-Induced Hypoglycemia in Adults With T1D Using Automated Insulin DeliveryNCT06880835 · collaborator · 2025-06-05
RECRUITING
Inhaled Insulin vs Rapid-acting Injections for Post-meal Glucose Control in Women With Gestational DiabetesNCT06535789 · collaborator · 2025-05-01
RECRUITING
A Study to Evaluate Time in Range in Type 2 Diabetics Using Afrezza® Plus Basal Insulin Compared to Multiple Daily InjectionsNCT04125082 · collaborator · 2019-02-27
UNKNOWN
Initiating Mealtime Ultra-Rapid Acting Insulin (Afrezza) in Uncontrolled Type 2 Diabetes PatientsNCT03324776 · collaborator · 2017-10-16
COMPLETED
A Randomized Controlled Trial Evaluating One Drop | Premium With Afrezza vs. One Drop | Premium AloneNCT03313960 · collaborator · 2017-10-05
UNKNOWN
Study Comparing Prandial Insulin Aspart vs. Technosphere Insulin in Patients With Type 1 Diabetes on Multiple Daily Injections: Investigator-Initiated A Real-life Pilot Study-STAT StudyNCT03143816 · collaborator · 2017-09-30
COMPLETED
Single Site, Single Subject, Treatment IND With Mannkind Corporation's Technosphere Inhalation SystemNCT01459133 · collaborator · 2013-05-01
WITHDRAWN

Sponsor roles

lead sponsor42
collaborator7

Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.