Sponsor

National Institute of Mental Health (NIMH)

Clinical research sponsor

Published trials1,389
Recruiting shown12
Roles2
SourceClinicalTrials.gov

Clinical trials

60 shown
PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)NCT07169630 · lead sponsor · 2026-10-12
RECRUITING
Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant DepressionNCT06511908 · lead sponsor · 2024-11-06
RECRUITING
Natural History of Depression, Bipolar Disorder and Suicide RiskNCT06462196 · lead sponsor · 2024-09-09
RECRUITING
NIMH Rhythms and Blues Study: A Prospective Natural History Study of Motor Activity, Mood States, and Bipolar DisorderNCT05669703 · lead sponsor · 2023-11-03
RECRUITING
[18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PETNCT05703685 · lead sponsor · 2023-06-22
RECRUITING
PET Imaging of Cyclooxygenases in Neurodegenerative Brain DiseaseNCT04396873 · lead sponsor · 2021-08-17
RECRUITING
PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)NCT04582916 · lead sponsor · 2021-07-20
RECRUITING
Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major DepressionNCT03973268 · lead sponsor · 2020-01-21
RECRUITING
Characterization and Treatment of Adolescent DepressionNCT03388606 · lead sponsor · 2017-12-28
RECRUITING
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive DisorderNCT03065335 · lead sponsor · 2017-05-25
RECRUITING
Neurobiology of SuicideNCT02543983 · lead sponsor · 2015-12-01
RECRUITING
Study of Neuro-Cognitive Correlates of Pediatric Anxiety DisordersNCT00018057 · lead sponsor · 2001-10-02
RECRUITING
Transcranial Magnetic Stimulation for Youth With Treatment-Resistant Major Depressive DisorderNCT05652465 · lead sponsor · 2026-04-25
WITHDRAWN
Title: Safety and Feasibility of Individualized Low Amplitude Seizure Therapy (iLAST)NCT03895658 · lead sponsor · 2025-02-26
WITHDRAWN
Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD)NCT05172271 · lead sponsor · 2022-11-08
ACTIVE_NOT_RECRUITING
PET Imaging of Cyclooxygenase in Multiple SclerosisNCT05062083 · lead sponsor · 2022-06-07
TERMINATED
Antidepressant Effects of TS-161 in Treatment-Resistant DepressionNCT04821271 · lead sponsor · 2021-06-10
TERMINATED
Phase 1 Evaluation of (2R,6R)-HydroxynorketamineNCT04711005 · lead sponsor · 2021-01-11
COMPLETED
PET Imaging of Neuroinflammation in Neurodegenerative Diseases Via a Novel Translocator Protein (TSPO) RadioligandNCT03958630 · lead sponsor · 2019-07-03
TERMINATED
Novel PET Radioligand as an Inflammatory Biomarker in Musculoskeletal ConditionsNCT03912428 · lead sponsor · 2019-06-14
TERMINATED
Concurrent fMRI-guided rTMS and Cognitive Therapy for the Treatment of Major Depressive EpisodesNCT03289923 · lead sponsor · 2018-05-17
COMPLETED
Procedures for Sample Acquisition and Distribution for The Human Brain Collection CoreNCT03092687 · lead sponsor · 2017-03-21
TERMINATED
Antidepressant Effects of the Glycine Receptor Antagonist AV-101 (4-chlorokynurenine) in Major Depressive DisorderNCT02484456 · lead sponsor · 2015-10-14
COMPLETED
Does Enhanced Glutamate Transporter Function Produce Antidepressant Effects in People With Major Depression?NCT02049385 · lead sponsor · 2014-01-03
TERMINATED
PET Imaging of Brain mGluR1 Receptors Using [18F]FIMXNCT02230592 · lead sponsor · 2013-11-08
COMPLETED
Brain Inflammation in Major Depressive Disorder BackgroundNCT01851356 · lead sponsor · 2013-05-08
COMPLETED
Daily Intranasal Oxytocin for Childhood-Onset SchizophreniaNCT01712646 · lead sponsor · 2012-10-05
TERMINATED
Depression Outcomes Study of ExerciseNCT00964054 · lead sponsor · 2012-09-01
COMPLETED
Brain Imaging, Genetics and Treatment for Major DepressionNCT01568684 · lead sponsor · 2012-03-12
WITHDRAWN
Mild Neurocognitive Disorder in HIV Infection of the BrainNCT01547754 · lead sponsor · 2012-01-09
TERMINATED
Oxytocin and Arginine Vasopressin in Pain ReliefNCT01328561 · lead sponsor · 2011-03-17
TERMINATED
Imaging Serotonin 5HT1A Receptors in Patients With Major Depressive DisorderNCT01313403 · lead sponsor · 2011-02-10
WITHDRAWN
PET Whole Body Distribution Studies Using [11C]CUMINCT01132872 · lead sponsor · 2010-04-30
COMPLETED
Brain Imaging Study of Adults With Autism Spectrum DisordersNCT01093768 · lead sponsor · 2010-02-19
COMPLETED
Imaging Cannabinoid CB1 Receptors in SchizophreniaNCT01063335 · lead sponsor · 2010-02-01
TERMINATED
Functional Relevance of Dopamine Receptors in Healthy Controls and Patients With Schizophrenia: Characterization Through [11C]NNC-112 and [18F]Fallypride Positron Emission TomographyNCT00942981 · lead sponsor · 2009-11-13
COMPLETED
Screening and Evaluation of Patients With Signs and Symptoms of Alzheimer's DiseaseNCT00955422 · lead sponsor · 2009-07-31
COMPLETED
Feasibility of Providing Cognitive Remediation to People With Schizophrenia in a Clinical NetworkNCT00930150 · lead sponsor · 2009-07-01
COMPLETED
Development and Decline of Brain and Cognition Through the Life SpanNCT00880451 · lead sponsor · 2009-03-01
COMPLETED
The Use of a Distress Thermometer in a Pediatric Research Setting: An Exploratory Pilot StudyNCT00824278 · lead sponsor · 2009-01-13
COMPLETED
The Use of Metformin in the Treatment of Antipsychotic-Induced Weight Gain in Schizophrenia (The METS Study)NCT00816907 · lead sponsor · 2009-01-01
COMPLETED
Comparison of Optimal Antipsychotic Treatments for Adults With SchizophreniaNCT00802100 · lead sponsor · 2008-12-01
COMPLETED
Transcranial Direct Current Brain Stimulation to Treat Patients With Childhood-Onset SchizophreniaNCT00757497 · lead sponsor · 2008-09-17
TERMINATED
p11 Protein Levels in Patients With Major Depressive Disorder Treated With CitalopramNCT00697268 · lead sponsor · 2008-06-03
COMPLETED
P-glycoprotein Function in Brain DiseasesNCT00677885 · lead sponsor · 2008-05-09
COMPLETED
Combining Medications to Enhance Depression OutcomesNCT00590863 · lead sponsor · 2008-03-01
COMPLETED
The Effects of Atomoxetine on Cognition and Brain Function Based on Catechol-O-methyltransferase(COMT) GenotypeNCT00548327 · lead sponsor · 2007-10-01
TERMINATED
Assessing Treatment Emergent Suicidal Ideation in Patients With Major DepressionNCT00532103 · lead sponsor · 2007-07-01
COMPLETED
Antidepressant Effects of NR2B in Major DepressionNCT00472576 · lead sponsor · 2007-05-01
COMPLETED
PET Evaluation of Brain Peripheral Benzodiazepine Receptors Using [11C]PBR28 in HIV-Seropositive Patients With (MCMD)NCT00459693 · lead sponsor · 2007-04-09
TERMINATED
Comparison of Antipsychotics for Metabolic Problems in Schizophrenia or Schizoaffective DisorderNCT00423878 · lead sponsor · 2007-01-01
COMPLETED
PET Imaging of Brain Amyloid Using [11C]MeS-IMPYNCT00407576 · lead sponsor · 2006-12-01
COMPLETED
Antidepressant Effects on cAMP Specific Phosphodiesterase (PDE4) in Depressed PatientsNCT00369798 · lead sponsor · 2006-08-02
COMPLETED
The Antidepressant Efficacy of the Anticholinergic ScopolamineNCT00369915 · lead sponsor · 2006-08-01
TERMINATED
Identifying the Role of Oxytocin and Vasopressin in the Functioning of Neurocognitive Systems Involved in Mood DisordersNCT00325065 · lead sponsor · 2006-05-05
COMPLETED
Usability of a Website for People With SchizophreniaNCT00177879 · lead sponsor · 2005-08-01
WITHDRAWN
Dopamine Receptor Imaging in Mood DisordersNCT00116077 · lead sponsor · 2005-06-21
COMPLETED
Determining the Prevalence of HIV-Related Neurological Disorders in the Asia PacificNCT00168246 · lead sponsor · 2005-06-01
UNKNOWN
Org 24448 to Treat Major DepressionNCT00113022 · lead sponsor · 2005-05-01
TERMINATED
Velocardiofacial (VCFS; 22q11.2; DiGeorge) Syndrome StudyNCT00105274 · lead sponsor · 2005-03-07
COMPLETED

Sponsor roles

collaborator1,249
lead sponsor140

Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.