Clinical trial

A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer

NCT07102381

Drugs and interventions used in this trial

6 registered

These interventions are listed by ClinicalTrials.gov. An RxNorm link indicates a mapped medicine record; the registry name alone is not proof of a specific branded formulation.

Search this trial's interventions

DRUG · Mapped RxNorm record Zanidatamab Normalized identity: zanidatamabView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Paclitaxel Normalized identity: paclitaxelView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Docetaxel Normalized identity: docetaxelView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Carboplatin Normalized identity: carboplatinView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Trastuzumab Normalized identity: trastuzumabView linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Pertuzumab Normalized identity: pertuzumabView linked drug · Find medicine records · Find other trials using this name

Study at a glance

Registry-backed

A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer

Design: INTERVENTIONAL · Status: RECRUITING · Phase: PHASE2

Read study objectives, eligibility and outcome measures at ClinicalTrials.gov

StatusRECRUITING

Study typeINTERVENTIONAL

Start date2025-09-24

PhasePHASE2

Conditions

HER2-positive Breast Cancercandidate · MONDO: HER2 positive breast carcinoma

Breast Cancerverified · MONDO: breast cancer

Interventions

ZanidatamabDRUG · verified · RxNorm: zanidatamab

PaclitaxelDRUG · verified · RxNorm: paclitaxel

DocetaxelDRUG · verified · RxNorm: docetaxel

CarboplatinDRUG · verified · RxNorm: carboplatin

TrastuzumabDRUG · verified · RxNorm: trastuzumab

PertuzumabDRUG · verified · RxNorm: pertuzumab

Sponsors & collaborators

Jazz Pharmaceuticalslead sponsor

Jazz Pharmaceuticals Ireland Limitedcollaborator

Mapped research locations

BarcelonaSpain3 DallasTexas, United States2 New YorkNew York, United States1 HoustonTexas, United States1 San AntonioTexas, United States1 NashvilleTennessee, United States1 MadridSpain1 DenverColorado, United States1 DetroitMichigan, United States1 MilanItaly1 OmahaNebraska, United States1 CharlotteNorth Carolina, United States1

Registry source

Open the source record to verify current eligibility, contacts, locations and registry updates.

Open NCT07102381 on ClinicalTrials.gov ↗

Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.