Clinical trial

A Phase III, Non-Inferiority, Randomized, Open-Label, Parallel Group, Multicenter Study To Investigate The Pharmacokinetics, Pharmacodynamics, Safety And Radiological And Clinical Effects Of Subcutaneous Ocrelizumab Versus Intravenous Ocrelizumab In Patients With Multiple Sclerosis

NCT05232825

Drugs and interventions used in this trial

6 registered

These interventions are listed by ClinicalTrials.gov. An RxNorm link indicates a mapped medicine record; the registry name alone is not proof of a specific branded formulation.

Search this trial's interventions

DRUG · Unmapped registry intervention Ocrelizumab IV Find medicine records · Find other trials using this name

DRUG · Unmapped registry intervention Ocrelizumab SC Find medicine records · Find other trials using this name

DRUG · Unmapped registry intervention Methylprednisolone IV Find medicine records · Find other trials using this name

DRUG · Unmapped registry intervention Diphenhydramine IV Find medicine records · Find other trials using this name

DRUG · Unmapped registry intervention Dexamethasone given orally Find medicine records · Find other trials using this name

DRUG · Unmapped registry intervention Desloratadine given orally Find medicine records · Find other trials using this name

Study at a glance

Registry-backed

A Phase III, Non-Inferiority, Randomized, Open-Label, Parallel Group, Multicenter Study To Investigate The Pharmacokinetics, Pharmacodynamics, Safety And Radiological And Clinical Effects Of Subcutaneous Ocrelizumab Versus Intravenous Ocrelizumab In Patients With Multiple Sclerosis

Design: INTERVENTIONAL · Status: COMPLETED · Phase: PHASE3

Read study objectives, eligibility and outcome measures at ClinicalTrials.gov

StatusCOMPLETED

Study typeINTERVENTIONAL

Start date2022-05-03

PhasePHASE3

Conditions

Relapsing Multiple Sclerosisunresolved

Primary Progressive Multiple Sclerosisverified · MONDO: primary progressive multiple sclerosis

Interventions

Ocrelizumab IVDRUG

Ocrelizumab SCDRUG

Methylprednisolone IVDRUG

Diphenhydramine IVDRUG

Dexamethasone given orallyDRUG

Desloratadine given orallyDRUG

Sponsors & collaborators

Hoffmann-La Rochelead sponsor

Mapped research locations

PragueCzechia2 IstanbulTurkey (Türkiye)2 BaltimoreMaryland, United States1 BarcelonaSpain1 TampaFlorida, United States1 GreenvilleSouth Carolina, United States1 LodzPoland1 DaytonOhio, United States1 BrnoCzechia1 BydgoszczPoland1 IzmirTurkey (Türkiye)1 KatowicePoland1

Registry source

Open the source record to verify current eligibility, contacts, locations and registry updates.

Open NCT05232825 on ClinicalTrials.gov ↗

Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.