Clinical trial

Deferasirox in Treating Iron Overload Caused By Blood Transfusions in Patients With Hematologic Malignancies

NCT01273766

Study summary

ClinicalTrials.gov

Deferasirox in Treating Iron Overload Caused By Blood Transfusions in Patients With Hematologic Malignancies

Design: INTERVENTIONAL · Status: COMPLETED · Phase: PHASE2

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Drugs and interventions used in this trial

3 registered

These interventions are listed by ClinicalTrials.gov. An RxNorm link indicates a mapped medicine record; the registry name alone is not proof of a specific branded formulation.

DRUG · Mapped RxNorm record deferasirox Normalized identity: deferasirox View linked drug · Find medicine records · Find other trials using this name

OTHER · Unmapped registry intervention laboratory biomarker analysis Find medicine records · Find other trials using this name

OTHER · Unmapped registry intervention enzyme-linked immunosorbent assay Find medicine records · Find other trials using this name

StatusCOMPLETED

Study typeINTERVENTIONAL

Start date2011-01-01

PhasePHASE2

Conditions

Acute Undifferentiated Leukemiaverified · MONDO: acute undifferentiated leukemia

Adult Acute Lymphoblastic Leukemia in Remissionunresolved

Adult Acute Myeloid Leukemia in Remissionunresolved

Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalitiesunresolved

Adult Acute Myeloid Leukemia With Del(5q)unresolved

Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)unresolved

Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)unresolved

Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)unresolved

Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)unresolved

Adult Grade III Lymphomatoid Granulomatosisunresolved

Adult Langerhans Cell Histiocytosisverified · MONDO: Langerhans cell histiocytosis specific to adulthood

Adult Nasal Type Extranodal NK/T-cell Lymphomaunresolved

Anaplastic Large Cell Lymphomaverified · MONDO: anaplastic large cell lymphoma

Angioimmunoblastic T-cell Lymphomaverified · MONDO: angioimmunoblastic T-cell lymphoma

Contiguous Stage II Adult Burkitt Lymphomaunresolved

Contiguous Stage II Adult Diffuse Large Cell Lymphomaunresolved

Contiguous Stage II Adult Diffuse Mixed Cell Lymphomaunresolved

Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphomaunresolved

Contiguous Stage II Adult Immunoblastic Large Cell Lymphomaunresolved

Contiguous Stage II Adult Lymphoblastic Lymphomaunresolved

Contiguous Stage II Grade 1 Follicular Lymphomaunresolved

Contiguous Stage II Grade 2 Follicular Lymphomaunresolved

Contiguous Stage II Grade 3 Follicular Lymphomaunresolved

Contiguous Stage II Mantle Cell Lymphomaunresolved

Contiguous Stage II Marginal Zone Lymphomaunresolved

Contiguous Stage II Small Lymphocytic Lymphomaunresolved

Cutaneous B-cell Non-Hodgkin Lymphomaunresolved

de Novo Myelodysplastic Syndromesunresolved

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissueverified · MONDO: MALT lymphoma

Hepatosplenic T-cell Lymphomaverified · MONDO: hepatosplenic T-cell lymphoma

Intraocular Lymphomaverified · MONDO: intraocular lymphoma

Mast Cell Leukemiaverified · MONDO: mast cell leukemia

Myelodysplastic Syndrome With Isolated Del(5q)verified · MONDO: myelodysplastic syndrome associated with isolated del(5q)

Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiableunresolved

Myeloid/NK-cell Acute Leukemiaunresolved

Nodal Marginal Zone B-cell Lymphomaverified · MONDO: nodal marginal zone B-cell lymphoma

Noncontiguous Stage II Adult Burkitt Lymphomaunresolved

Noncontiguous Stage II Adult Diffuse Large Cell Lymphomaunresolved

Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphomaunresolved

Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphomaunresolved

Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphomaunresolved

Noncontiguous Stage II Adult Lymphoblastic Lymphomaunresolved

Noncontiguous Stage II Grade 1 Follicular Lymphomaunresolved

Noncontiguous Stage II Grade 2 Follicular Lymphomaunresolved

Noncontiguous Stage II Grade 3 Follicular Lymphomaunresolved

Noncontiguous Stage II Mantle Cell Lymphomaunresolved

Noncontiguous Stage II Marginal Zone Lymphomaunresolved

Noncontiguous Stage II Small Lymphocytic Lymphomaunresolved

Noncutaneous Extranodal Lymphomaunresolved

Peripheral T-cell Lymphomaverified · MONDO: mature T-cell and NK-cell non-Hodgkin lymphoma

Previously Treated Myelodysplastic Syndromesunresolved

Primary Myelofibrosisverified · MONDO: primary myelofibrosis

Recurrent Adult Acute Lymphoblastic Leukemiaunresolved

Recurrent Adult Acute Myeloid Leukemiaunresolved

Recurrent Adult Burkitt Lymphomaunresolved

Recurrent Adult Diffuse Large Cell Lymphomaunresolved

Recurrent Adult Diffuse Mixed Cell Lymphomaunresolved

Recurrent Adult Diffuse Small Cleaved Cell Lymphomaunresolved

Recurrent Adult Grade III Lymphomatoid Granulomatosisunresolved

Recurrent Adult Hodgkin Lymphomaunresolved

Recurrent Adult Immunoblastic Large Cell Lymphomaunresolved

Recurrent Adult Lymphoblastic Lymphomaunresolved

Recurrent Adult T-cell Leukemia/Lymphomaunresolved

Recurrent Cutaneous T-cell Non-Hodgkin Lymphomaunresolved

Recurrent Grade 1 Follicular Lymphomaunresolved

Recurrent Grade 2 Follicular Lymphomaunresolved

Recurrent Grade 3 Follicular Lymphomaunresolved

Recurrent Mantle Cell Lymphomaunresolved

Recurrent Marginal Zone Lymphomaunresolved

Recurrent Mycosis Fungoides/Sezary Syndromeunresolved

Recurrent Small Lymphocytic Lymphomaunresolved

Refractory Anemiaverified · MONDO: myelodysplastic syndrome with single lineage dysplasia

Refractory Multiple Myelomaunresolved

Secondary Acute Myeloid Leukemiaverified · MONDO: therapy related acute myeloid leukemia and myelodysplastic syndrome

Secondary Myelofibrosisunresolved

Small Intestine Lymphomaverified · MONDO: small intestine lymphoma

Splenic Marginal Zone Lymphomaverified · MONDO: splenic marginal zone lymphoma

Stage I Adult Burkitt Lymphomaunresolved

Stage I Adult Diffuse Large Cell Lymphomaunresolved

Stage I Adult Diffuse Mixed Cell Lymphomaunresolved

Stage I Adult Diffuse Small Cleaved Cell Lymphomaunresolved

Stage I Adult Hodgkin Lymphomaunresolved

Stage I Adult Immunoblastic Large Cell Lymphomaunresolved

Stage I Adult Lymphoblastic Lymphomaunresolved

Stage I Adult T-cell Leukemia/Lymphomaunresolved

Stage I Cutaneous T-cell Non-Hodgkin Lymphomaunresolved

Stage I Grade 1 Follicular Lymphomaunresolved

Stage I Grade 2 Follicular Lymphomaunresolved

Stage I Grade 3 Follicular Lymphomaunresolved

Stage I Mantle Cell Lymphomaunresolved

Stage I Marginal Zone Lymphomaunresolved

Stage I Multiple Myelomaunresolved

Stage I Mycosis Fungoides/Sezary Syndromeunresolved

Stage I Small Lymphocytic Lymphomaunresolved

Stage II Adult Hodgkin Lymphomaunresolved

Stage II Adult T-cell Leukemia/Lymphomaunresolved

Stage II Cutaneous T-cell Non-Hodgkin Lymphomaunresolved

Stage II Multiple Myelomaunresolved

Stage II Mycosis Fungoides/Sezary Syndromeunresolved

Stage III Adult Burkitt Lymphomaunresolved

Stage III Adult Diffuse Large Cell Lymphomaunresolved

Stage III Adult Diffuse Mixed Cell Lymphomaunresolved

Stage III Adult Diffuse Small Cleaved Cell Lymphomaunresolved

Stage III Adult Hodgkin Lymphomaunresolved

Stage III Adult Immunoblastic Large Cell Lymphomaunresolved

Stage III Adult Lymphoblastic Lymphomaunresolved

Stage III Adult T-cell Leukemia/Lymphomaunresolved

Stage III Cutaneous T-cell Non-Hodgkin Lymphomaunresolved

Stage III Grade 1 Follicular Lymphomaunresolved

Stage III Grade 2 Follicular Lymphomaunresolved

Stage III Grade 3 Follicular Lymphomaunresolved

Stage III Mantle Cell Lymphomaunresolved

Stage III Marginal Zone Lymphomaunresolved

Stage III Multiple Myelomaunresolved

Stage III Mycosis Fungoides/Sezary Syndromeunresolved

Stage III Small Lymphocytic Lymphomaunresolved

Stage IV Adult Burkitt Lymphomaunresolved

Stage IV Adult Diffuse Large Cell Lymphomaunresolved

Stage IV Adult Diffuse Mixed Cell Lymphomaunresolved

Stage IV Adult Diffuse Small Cleaved Cell Lymphomaunresolved

Stage IV Adult Hodgkin Lymphomaunresolved

Stage IV Adult Immunoblastic Large Cell Lymphomaunresolved

Stage IV Adult Lymphoblastic Lymphomaunresolved

Stage IV Adult T-cell Leukemia/Lymphomaunresolved

Stage IV Cutaneous T-cell Non-Hodgkin Lymphomaunresolved

Stage IV Grade 1 Follicular Lymphomaunresolved

Stage IV Grade 2 Follicular Lymphomaunresolved

Stage IV Grade 3 Follicular Lymphomaunresolved

Stage IV Mantle Cell Lymphomaunresolved

Stage IV Marginal Zone Lymphomaunresolved

Stage IV Mycosis Fungoides/Sezary Syndromeunresolved

Stage IV Small Lymphocytic Lymphomaunresolved

Testicular Lymphomaverified · MONDO: testicular lymphoma

Untreated Adult Acute Lymphoblastic Leukemiaunresolved

Untreated Adult Acute Myeloid Leukemiaunresolved

Waldenstrom Macroglobulinemiaverified · MONDO: Waldenstrom macroglobulinemia

Interventions

deferasiroxDRUG · verified · RxNorm: deferasirox

laboratory biomarker analysisOTHER

enzyme-linked immunosorbent assayOTHER

Sponsors & collaborators

Wake Forest University Health Scienceslead sponsor

National Cancer Institute (NCI)collaborator

Mapped research locations

Winston-SalemNorth Carolina, United States1

Registry source

Open the source record to verify current eligibility, contacts, locations and registry updates.

Open NCT01273766 on ClinicalTrials.gov ↗

Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.