Clinical trial

Randomized Phase I Study of Trimetrexate Glucuronate (TMTX) With Leucovorin (LCV) Protection Plus Dapsone Versus Trimethoprim / Sulfamethoxazole (TMP/SMX) for Treatment of Moderately Severe Episodes of Pneumocystis Carinii Pneumonia

NCT00002120

Study summary

ClinicalTrials.gov

Design: INTERVENTIONAL · Status: COMPLETED · Phase: PHASE1

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Drugs and interventions used in this trial

5 registered

These interventions are listed by ClinicalTrials.gov. An RxNorm link indicates a mapped medicine record; the registry name alone is not proof of a specific branded formulation.

DRUG · Unmapped registry intervention Trimetrexate glucuronate Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Trimethoprim Normalized identity: trimethoprim View linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Sulfamethoxazole Normalized identity: sulfamethoxazole View linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Dapsone Normalized identity: dapsone View linked drug · Find medicine records · Find other trials using this name

DRUG · Mapped RxNorm record Leucovorin calcium Normalized identity: leucovorin calcium View linked drug · Find medicine records · Find other trials using this name

StatusCOMPLETED

Study typeINTERVENTIONAL

Start dateUnknown

PhasePHASE1

Conditions

Pneumonia, Pneumocystis Cariniiunresolved

HIV Infectionsunresolved

Interventions

Trimetrexate glucuronateDRUG

TrimethoprimDRUG · verified · RxNorm: trimethoprim

SulfamethoxazoleDRUG · verified · RxNorm: sulfamethoxazole

DapsoneDRUG · verified · RxNorm: dapsone

Leucovorin calciumDRUG · verified · RxNorm: leucovorin calcium

Sponsors & collaborators

U.S. Biosciencelead sponsor

Jacobus Pharmaceuticalcollaborator

Mapped research locations

Los AngelesCalifornia, United States1

Registry source

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Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.