Clinical trial
Rapid Antidepressant Improvement Secondary to Excitatory Brain Responses
NCT04276259
Study timeline
Study start (actual)2020-10-19Date precision: day
Registry last updated2026-07-31
Observed by CureCurrent2026-10-07
Recorded dates are source observations, not predictions. Missing milestones are not estimated.
Conditions
Major Depressive Disorderunresolved
Depressionunresolved
Interventions
BuprenorphineDRUG · verified · RxNorm: buprenorphine
NaltrexoneDRUG · verified · RxNorm: naltrexone
Oral PlaceboDRUG
IM PlaceboDRUG
Sponsors & collaborators
Marta Peciña, MD PhDlead sponsor
National Institute of Mental Health (NIMH)collaborator
Mapped research locations
Registry source
Open the source record to verify current eligibility, contacts, locations and registry updates.
Open NCT04276259 on ClinicalTrials.gov ↗Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.