Clinical trial

SPIRO-First: A Pragmatic Primary Care-Embedded Pilot Trial of Renin-Guided First-Line Antihypertensive Therapy

NCT07687160

Drugs and interventions used in this trial

4 registered

These interventions are listed by ClinicalTrials.gov. An RxNorm link indicates a mapped medicine record; the registry name alone is not proof of a specific branded formulation.

Search this trial's interventions

DRUG · Unmapped registry intervention Spironolactone (drug) Find medicine records · Find other trials using this name

DRUG · Unmapped registry intervention Candesartan 8mg Find medicine records · Find other trials using this name

DRUG · Unmapped registry intervention Hydrochlorothiazide (HCTZ) 25 milligrams. Find medicine records · Find other trials using this name

DRUG · Unmapped registry intervention Amlodipine (5mg) Find medicine records · Find other trials using this name

Study at a glance

Registry-backed

SPIRO-First: A Pragmatic Primary Care-Embedded Pilot Trial of Renin-Guided First-Line Antihypertensive Therapy

Design: INTERVENTIONAL · Status: NOT YET RECRUITING · Phase: PHASE4

Read study objectives, eligibility and outcome measures at ClinicalTrials.gov

StatusNOT_YET_RECRUITING

Study typeINTERVENTIONAL

Start date2026-09-01

PhasePHASE4

Conditions

Hypertensionunresolved

Interventions

Spironolactone (drug)DRUG

Candesartan 8mgDRUG

Hydrochlorothiazide (HCTZ) 25 milligrams.DRUG

Amlodipine (5mg)DRUG

Sponsors & collaborators

Ottawa Hospital Research Institutelead sponsor

The Ottawa Hospitalcollaborator

Mapped research locations

OttawaOntario, Canada2

Registry source

Open the source record to verify current eligibility, contacts, locations and registry updates.

Open NCT07687160 on ClinicalTrials.gov ↗

Registry-derived research relationships: ClinicalTrials.gov. Raw condition and intervention labels remain distinct from canonical MONDO/RxNorm entities unless separately normalized.